{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T09:19:37Z","timestamp":1686907177553},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Food additives are widely used in industries. Overall, these additives have a beneficial role, but if their concentration exceeds certain limits, they may have an adverse effect on human health. Objective: This study outlines the determination of benzoic acid (BA), sorbic acid (SA), butylated hydroxyanisole (BHA), and butylated hydroxytoluene (BHT) in juices using dispersive liquid\u2013liquid microextraction and HPLC\u2013diode-array detection. Methods: Different parameters that significantly affect the extraction efficiency were optimized. The disperser and extraction solvents were acetone and chloroform, respectively. The other parameters were selected and optimized using two-level (2k) factorial and central composite designs, respectively. A full method validation using an accuracy profile for the total measurement error was carried out. Results: The optimized conditions were 625 \u03bcL acetone, 350 \u03bcL chloroform, 0.85 g NaCl, and pH 2. The validated method demonstrated good linearity with R2 \u2265 0.99 and good precision with the RSD of repeatability and intermediate precision at 1.97\u201310.7% and 2.31\u201311.9%, respectively. The relative recoveries were 96.2\u2013105.4%, and the LODs were around 0.03 \u03bcg\/mL for all compounds. The analysis of 41 samples revealed that BA and SA were quantified in 25 and 20 samples, respectively. BHA and BHT were not detected. Conclusions: The proposed methodology is an appropriate tool to determine important food additives in juices to ensure their compliance with the food additives legislation. Highlights: The work has demonstrated that the method can be successfully used in the simultaneous determination of four food additives in fruit juices.<\/jats:p>","DOI":"10.5740\/jaoacint.18-0104","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T01:08:26Z","timestamp":1530234506000},"page":"208-216","source":"Crossref","is-referenced-by-count":3,"title":["Simultaneous Extraction and Determination of Preservatives and Antioxidants in Juice Samples by an Optimized Microextraction Method Using Central Composite Design and Validated with Accuracy Profile"],"prefix":"10.1093","volume":"102","author":[{"given":"Abderrahmane","family":"Tighrine","sequence":"first","affiliation":[{"name":"Mouloud Mammeri University of Tizi Ouzou, Faculty of Biological and Agronomic Sciences, Laboratory of Quality and Food Safety (LQFS), Tizi Ouzou, Algeria 15000; Universidade do Porto, Faculdade de Farm\u00e1cia, LAQV-REQUIMTE\/Departamento de Ci\u00eancias Qu\u00edmicas, Laborat\u00f3rio de Bromatologia e Hidrologia, R. Jorge Viterbo Ferreira 228, Porto, Portugal 4050-313"}]},{"given":"Edgar","family":"Pinto","sequence":"additional","affiliation":[{"name":"Universidade do Porto, Faculdade de Farm\u00e1cia, LAQV-REQUIMTE\/Departamento de Ci\u00eancias Qu\u00edmicas, Laborat\u00f3rio de Bromatologia e Hidrologia, R. Jorge Viterbo Ferreira 228, Porto, Portugal 4050-313"}]},{"given":"Armindo","family":"Melo","sequence":"additional","affiliation":[{"name":"Universidade do Porto, Faculdade de Farm\u00e1cia, LAQV-REQUIMTE\/Departamento de Ci\u00eancias Qu\u00edmicas, Laborat\u00f3rio de Bromatologia e Hidrologia, R. Jorge Viterbo Ferreira 228, Porto, Portugal 4050-313; Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge, Departamento de Sa\u00fade Ambiental, Rua Alexandre Herculano 321, Porto, Portugal 4000-055"}]},{"given":"Isabel M P L V O","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade do Porto, Faculdade de Farm\u00e1cia, LAQV-REQUIMTE\/Departamento de Ci\u00eancias Qu\u00edmicas, Laborat\u00f3rio de Bromatologia e Hidrologia, R. Jorge Viterbo Ferreira 228, Porto, Portugal 4050-313"}]},{"given":"Marzouk","family":"Mamou","sequence":"additional","affiliation":[{"name":"Mouloud Mammeri University of Tizi Ouzou, Faculty of Medicine, Laboratory of Analytical Chemistry, Tizi Ouzou, Algeria 15000"}]},{"given":"Youcef","family":"Amir","sequence":"additional","affiliation":[{"name":"Mouloud Mammeri University of Tizi Ouzou, Faculty of Biological and Agronomic Sciences, Laboratory of Quality and Food Safety (LQFS), Tizi Ouzou, Algeria 15000"}]}],"member":"286","published-online":{"date-parts":[[2019,11,23]]},"container-title":["Journal of AOAC INTERNATIONAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/102\/1\/208\/32428879\/jaoac0208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/102\/1\/208\/32428879\/jaoac0208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T18:18:47Z","timestamp":1584641927000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaoac\/article\/102\/1\/208-216\/5658142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,11,23]]},"published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.5740\/jaoacint.18-0104","relation":{},"ISSN":["1060-3271","1944-7922"],"issn-type":[{"value":"1060-3271","type":"print"},{"value":"1944-7922","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1,1]]},"published":{"date-parts":[[2019,1,1]]}}}