{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:03:42Z","timestamp":1777421022769,"version":"3.51.4"},"reference-count":60,"publisher":"Editorial Committee of Annals of Thoracic and Cardiovascular Surgery","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ATCS","Ann Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025]]},"DOI":"10.5761\/atcs.oa.25-00092","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T22:09:16Z","timestamp":1763676556000},"page":"n\/a","source":"Crossref","is-referenced-by-count":1,"title":["Predictive Value of Normalized Lactate Load for Patients with Acute Type A Aortic Dissection: Based on the MIMIC-IV Database"],"prefix":"10.5761","volume":"31","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"The Second Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People\u2019s Hospital, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Jiang","sequence":"additional","affiliation":[{"name":"Nephrology Department, Shaanxi Provincial People\u2019s Hospital, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3757","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Strecker T, Wiesmueller F, Rudnik-Schoneborn S, et al. Familial acute aortic dissection associated with a novel ACTA2 germline variant. Virchows Arch 2023; 482: 437\u201343.","DOI":"10.1007\/s00428-022-03366-9"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Chen MT, Chung CH, Ke HY, et al. Risk of aortic aneurysm and dissection in patients with tuberculosis: a nationwide population-based cohort study. Int J Environ Res Public Health 2021; 18: 11075.","DOI":"10.3390\/ijerph182111075"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Jiang T, Si L. Identification of the molecular mechanisms associated with acute type A aortic dissection through bioinformatics methods. Braz J Med Biol Res 2019; 52: e8950.","DOI":"10.1590\/1414-431x20198950"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Zhu Y, Lingala B, Baiocchi M, et al. Type A aortic dissection\u2014experience over 5 decades: JACC historical breakthroughs in perspective. J Am Coll Cardiol 2020; 76: 1703\u201313.","DOI":"10.1016\/j.jacc.2020.07.061"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Wang X, Li Z. Sudden right lower limb paralysis: an uncommon presentation of type A aortic dissection. Chest 2025; 168: e1\u20132.","DOI":"10.1016\/j.chest.2025.02.020"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Nallamothu BK, Mehta RH, Saint S, et al. Syncope in acute aortic dissection: diagnostic, prognostic, and clinical implications. Am J Med 2002; 113: 468\u201371.","DOI":"10.1016\/S0735-1097(02)81078-6"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Evangelista A, Isselbacher EM, Bossone E, et al. Insights from the international registry of acute aortic dissection: a 20-year experience of collaborative clinical research. Circulation 2018; 137: 1846\u201360.","DOI":"10.1161\/CIRCULATIONAHA.117.031264"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Harris KM, Nienaber CA, Peterson MD, et al. Early mortality in type A acute aortic dissection: insights from the international registry of acute aortic dissection. JAMA Cardiol 2022; 7: 1009\u201315.","DOI":"10.1001\/jamacardio.2022.2718"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Gilbey T, Milne B, Agarwal S, et al. Time critical diagnoses and transfers of patients with acute type A aortic dissection in the UK: national audit of current practice. Anaesthesia 2024; 80: 248\u201358.","DOI":"10.1111\/anae.16443"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Liu Q, Zheng HL, Wu MM, et al. Association between lactate-to-albumin ratio and 28-days all-cause mortality in patients with acute pancreatitis: A retrospective analysis of the MIMIC-IV database. Front Immunol 2022; 13: 1076121.","DOI":"10.3389\/fimmu.2022.1076121"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Fuernau G, Desch S, de Waha-Thiele S, et al. Arterial lactate in cardiogenic shock: prognostic value of clearance versus single values. JACC Cardiovasc Interv 2020; 13: 2208\u201316.","DOI":"10.1016\/j.jcin.2020.06.037"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Liang D, Zhou X, Hong X, et al. Association between admission lactate levels and mortality in patients with acute coronary syndrome: a retrospective cohort study. Coron Artery Dis 2019; 30: 26\u201332.","DOI":"10.1097\/MCA.0000000000000674"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Chen H, Gong SR, Yu RG. Association between normalized lactate load and mortality in patients with septic shock: an analysis of the MIMIC-III database. BMC Anesthesiol 2021; 21: 16.","DOI":"10.1186\/s12871-021-01239-3"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Zhang Z, Ni H. Normalized lactate load is associated with development of acute kidney injury in patients who underwent cardiopulmonary bypass surgery. PLoS One 2015; 10: e0120466.","DOI":"10.1371\/journal.pone.0120466"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Yuzefpolskaya M, Schwartz S, Ladanyi A, et al. The role of lactate metabolism in heart failure and cardiogenic shock: clinical insights and therapeutic implications. J Card Fail 2025; S1071-9164(25)00041-7.","DOI":"10.1016\/j.cardfail.2025.01.011"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Moradi S, Firoozbakhtian A, Hosseini M, et al. Advancements in wearable technology for monitoring lactate levels using lactate oxidase enzyme and free enzyme as analytical approaches: A review. Int J Biol Macromol 2024; 254: 127577.","DOI":"10.1016\/j.ijbiomac.2023.127577"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Masyuk M, Wernly B, Lichtenauer M, et al. Prognostic relevance of serum lactate kinetics in critically ill patients. Intensive Care Med 2019; 45: 55\u201361.","DOI":"10.1007\/s00134-018-5475-3"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Khadzhynov D, Dahlinger A, Schelter C, et al. Hyperlactatemia, lactate kinetics and prediction of citrate accumulation in critically ill patients undergoing continuous renal replacement therapy with regional citrate anticoagulation. Crit Care Med 2017; 45: e941\u20136.","DOI":"10.1097\/CCM.0000000000002501"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Hu Y, Zhao Y, Zhang J, et al. The association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from MIMIC-IV database. Cardiovasc Diabetol 2024; 23: 64.","DOI":"10.1186\/s12933-024-02153-x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Chen Y, Ouyang T, Yin Y, et al. The prognosis of patients with postoperative hyperglycemia after Stanford type A aortic dissection surgery and construction of prediction model for postoperative hyperglycemia. Front Endocrinol (Lausanne) 2023; 14: 1063496.","DOI":"10.3389\/fendo.2023.1063496"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Lei J, Zhang Z, Li Y, et al. Machine learning-based prognostic model for in-hospital mortality of aortic dissection: Insights from an intensive care medicine perspective. Digit Health 2024; 10: 20552076241269450.","DOI":"10.1177\/20552076241269450"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Kamel KS, Oh MS, Halperin ML. L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis. Kidney Int 2020; 97: 75\u201388.","DOI":"10.1016\/j.kint.2019.08.023"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Zanza C, Facelli V, Romenskaya T, et al. Lactic acidosis related to pharmacotherapy and human diseases. Pharmaceuticals (Basel) 2022; 15: 1496.","DOI":"10.3390\/ph15121496"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Ferreruela M, Raurich JM, Ayestaran I, et al. Hyperlactatemia in ICU patients: Incidence, causes and associated mortality. J Crit Care 2017; 42: 200\u20135.","DOI":"10.1016\/j.jcrc.2017.07.039"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Rishu AH, Khan R, Al-Dorzi HM, et al. Even mild hyperlactatemia is associated with increased mortality in critically ill patients. Crit Care 2013; 17: R197.","DOI":"10.1186\/cc12891"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Chen H, Gong SR, Yu RG. Increased normalized lactate load is associated with higher mortality in both sepsis and non-sepsis patients: an analysis of the MIMIC-IV database. BMC Anesthesiol 2022; 22: 79.","DOI":"10.1186\/s12871-022-01617-5"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Wu Y, Huang N, Sun T, et al. Association between normalized lactate load and in-hospital mortality in patients with acute myocardial infarction. Int J Cardiol 2024; 399: 131658.","DOI":"10.1016\/j.ijcard.2023.131658"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Wu X, Yuan L, Xu J, et al. Normalized lactate load as an independent prognostic indicator in patients with cardiogenic shock. BMC Cardiovasc Disord 2024; 24: 348.","DOI":"10.1186\/s12872-024-04013-8"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Biancari F, Nappi F, Gatti G, et al. Preoperative arterial lactate and outcome after surgery for type A aortic dissection: The ERTAAD multicenter study. Heliyon 2023; 9: e20702.","DOI":"10.1016\/j.heliyon.2023.e20702"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Wang S, Wang D, Huang X, et al. Risk factors and in-hospital mortality of postoperative hyperlactatemia in patients after acute type A aortic dissection surgery. BMC Cardiovasc Disord 2021; 21: 431.","DOI":"10.1186\/s12872-021-02244-7"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Chen Y, Peng Y, Zhang X, et al. The blood glucose-potassium ratio at admission predicts in-hospital mortality in patients with acute type A aortic dissection. Sci Rep 2023; 13: 15707.","DOI":"10.1038\/s41598-023-42827-2"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Krogager ML, Kragholm K, Thomassen JQ, et al. Update on management of hypokalaemia and goals for the lower potassium level in patients with cardiovascular disease: a review in collaboration with the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. Eur Heart J Cardiovasc Pharmacother 2021; 7: 557\u201367.","DOI":"10.1093\/ehjcvp\/pvab038"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Chen Z, Huang B, Lu H, et al. The effect of admission serum potassium levels on in-hospital and long-term mortality in type A acute aortic dissection. Clin Biochem 2017; 50: 843\u201350.","DOI":"10.1016\/j.clinbiochem.2017.05.008"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Yuan H, Sun Z, Zhang Y, et al. Clinical analysis of risk factors for mortality in type A acute aortic dissection: a single study from China. Front Cardiovasc Med 2021; 8: 728568.","DOI":"10.3389\/fcvm.2021.728568"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Heldwein MB, Badreldin AM, Doerr F, et al. Logistic Organ Dysfunction Score (LODS): a reliable postoperative risk management score also in cardiac surgical patients? J Cardiothorac Surg 2011; 6: 110.","DOI":"10.1186\/1749-8090-6-110"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Mart\u00ednez-Solano J, Sousa-Casasnovas I, Bellon-Cano JM, et al. Lactate levels as a prognostic predict in cardiogenic shock under venoarterial extracorporeal membrane oxygenation support. Rev Esp Cardiol (Engl Ed) 2022; 75: 595\u2013603.","DOI":"10.1016\/j.rec.2021.08.020"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Thevathasan T, Gregers E, Rasalingam Mork S, et al. Lactate and lactate clearance as predictors of one-year survival in extracorporeal cardiopulmonary resuscitation - An international, multicentre cohort study. Resuscitation 2024; 198: 110149.","DOI":"10.1016\/j.resuscitation.2024.110149"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Li S, Fu W, Wang L. Role of macrophages in aortic dissection pathogenesis: insights from preclinical studies to translational prospective. Sci China Life Sci 2024; 67: 2354\u201367.","DOI":"10.1007\/s11427-024-2693-5"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Piao J, Park JS, Hwang DY, et al. Substance P blocks \u03b2-aminopropionitrile-induced aortic injury through modulation of M2 monocyte-skewed monocytopoiesis. Transl Res 2021; 228: 76\u201393.","DOI":"10.1016\/j.trsl.2020.08.005"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Mauricio D, Gratacos M, Franch-Nadal J. Diabetic microvascular disease in non-classical beds: the hidden impact beyond the retina, the kidney, and the peripheral nerves. Cardiovasc Diabetol 2023; 22: 314.","DOI":"10.1186\/s12933-023-02056-3"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Gao Z, Qin Z, An Z, et al. Prognostic value of preoperative hemoglobin levels for long-term outcomes of acute type B aortic dissection post-thoracic endovascular aortic repair. Front Cardiovasc Med 2020; 7: 588761.","DOI":"10.3389\/fcvm.2020.588761"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Chen Y, Li X, Wang Z, et al. Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection. Mol Med 2024; 30: 90.","DOI":"10.1186\/s10020-024-00859-y"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Shi F, Wang Z, Wu Q, et al. Iron deficiency promotes aortic media degeneration by activating endoplasmic reticulum stress-mediated IRE1 signaling pathway. Pharmacol Res 2022; 183: 106366.","DOI":"10.1016\/j.phrs.2022.106366"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Bennett JM, Wise ES, Hocking KM, et al. Hyperlactemia predicts surgical mortality in patients presenting with acute stanford type-A aortic dissection. J Cardiothorac Vasc Anesth 2017; 31: 54\u201360.","DOI":"10.1053\/j.jvca.2016.03.133"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Lin Y, Tao Y, Peng Y, et al. Postoperative lactate predicts in-hospital death in patients with acute type A aortic dissection. Int Heart J 2023; 64: 717\u201323.","DOI":"10.1536\/ihj.22-290"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Wang Q, Huang W, Kou B. Examining the relationships between air pollutants and the incidence of acute aortic dissection with electronic medical data in a moderately polluted area of northwest China. Inquiry 2021; 58: 469580211065691.","DOI":"10.1177\/00469580211065691"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Sorber R, Hicks CW. Diagnosis and management of acute aortic syndromes: dissection, penetrating aortic ulcer, and intramural hematoma. Curr Cardiol Rep 2022; 24: 209\u201316.","DOI":"10.1007\/s11886-022-01642-3"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Hang MM, Shen MR, Chen TL, et al. Factors influencing the prognosis of patients with cardiogenic shock treated with extracorporeal membrane oxygenation: a protocol for systematic review and meta-analysis. Medicine (Baltimore) 2024; 103: e38600.","DOI":"10.1097\/MD.0000000000038600"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Zhao J, Li J, Hassan W, et al. Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing. Ann Transl Med 2020; 8: 459.","DOI":"10.21037\/atm.2020.03.108"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Samanidis G, Kanakis M, Kourelis G, et al. Acute renal failure after acute type A aortic dissection repair. Insidious postoperative complication with poor short- and long-term prognosis. J Card Surg 2022; 37: 2618\u201320.","DOI":"10.1111\/jocs.16613"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Gargotta HR. Type A aortic dissection complicated by renal and lower extremity malperfusion. Adv Emerg Nurs J 2019; 41: 23\u201332.","DOI":"10.1097\/TME.0000000000000220"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Garc\u00eda-Camacho C, Marin-Paz AJ, Lagares-Franco C, et al. Continuous ultrafiltration during extracorporeal circulation and its effect on lactatemia: A randomized controlled trial. PLoS One 2020; 15: e0242411.","DOI":"10.1371\/journal.pone.0242411"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Kavanagh EP, Sultan S, Jordan F, et al. Hybrid repair versus conventional open repair for aortic arch dissection. Cochrane Database Syst Rev 2021; 7: CD012920.","DOI":"10.1002\/14651858.CD012920.pub2"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Ge Y, Zhang H, Qi Y, et al. Steal phenomenon of thoracic false lumen: imaging insights from postdissection cases. Circ Cardiovasc Imaging 2025; 18: e018220.","DOI":"10.1161\/CIRCIMAGING.125.018220"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Berger T, Maier A, Kletzer J, et al. Radiographic complicated and uncomplicated descending aortic dissections: aortic morphological differences by CT angiography and risk factor analysis. Eur Heart J Cardiovasc Imaging 2024; 25: 867\u201377.","DOI":"10.1093\/ehjci\/jeae030"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Levy B, Curtiaud A, Duarte K, et al. Association between mean hemodynamic variables during the first 24 h and outcomes in cardiogenic shock: identification of clinically relevant thresholds. Crit Care 2025; 29: 137.","DOI":"10.1186\/s13054-025-05356-0"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Liu S, Wu J, Banerjee O, et al. Big data analytics and scRNA-seq in human aortic aneurysms and dissections: role of endothelial MerTK. Theranostics 2025; 15: 202\u201315.","DOI":"10.7150\/thno.103851"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Zhang H, Li L, Wu J, et al. Time of dissociation between microcirculation, macrocirculation, and lactate levels in a rabbit model of early endotoxemic shock. Chin Med J (Engl) 2020; 133: 2153\u201360.","DOI":"10.1097\/CM9.0000000000000887"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Jin Z, Dong J, Li C, et al. A deep learning model for identifying the risk of mesenteric malperfusion in acute aortic dissection using initial diagnostic data: algorithm development and validation. J Med Internet Res 2025; 27: e72649.","DOI":"10.2196\/72649"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Rylski B, Schilling O, Czerny M. Acute aortic dissection: evidence, uncertainties, and future therapies. Eur Heart J 2023; 44: 813\u201321.","DOI":"10.1093\/eurheartj\/ehac757"}],"container-title":["Annals of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/atcs\/31\/1\/31_oa.25-00092\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T04:11:59Z","timestamp":1763784719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/atcs\/31\/1\/31_oa.25-00092\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5761\/atcs.oa.25-00092","relation":{},"ISSN":["1341-1098","2186-1005"],"issn-type":[{"value":"1341-1098","type":"print"},{"value":"2186-1005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"oa.25-00092"}}