{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:16:48Z","timestamp":1783142208367,"version":"3.54.6"},"reference-count":16,"publisher":"Editorial Committee of Annals of Thoracic and Cardiovascular Surgery","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ATCS","Ann Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2026]]},"DOI":"10.5761\/atcs.oa.25-00242","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:12:37Z","timestamp":1782857557000},"page":"n\/a","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Pathological Lymphovascular Invasion of Lung Adenocarcinoma after Induction Chemoradiotherapy"],"prefix":"10.5761","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3148-9366","authenticated-orcid":false,"given":"Takafumi","family":"Kabuto","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Kyoto, Japan"},{"name":"Department of Thoracic Surgery, Japanese Red Cross Wakayama Medical Center, Wakayama, Wakayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7341-6002","authenticated-orcid":false,"given":"Toshi","family":"Menju","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Toyooka Public Hospital, Toyooka, Hyogo, Japan"},{"name":"Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Kyoto, Japan"},{"name":"Department of Diagnostic Pathology, Nara Medical University, Kashihara, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Date","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Kyoto, Japan"},{"name":"Division of Thoracic Surgery, Duke University Medical Center, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3757","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Siegel RL, Miller KD, Wagle NS, et al. Cancer statistics, 2023. CA Cancer J Clin 2023; 73: 17\u201348.","DOI":"10.3322\/caac.21763"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Ziel E, Hermann G, Sen N, et al. Survival benefit of surgery after chemoradiotherapy for stage III (N0-2) non-small-cell lung cancer is dependent on pathologic nodal response. J Thorac Oncol 2015; 10: 1475\u201380.","DOI":"10.1097\/JTO.0000000000000639"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Kayawake H, Okumura N, Yamanashi K, et al. Non-small cell lung cancer with pathological complete response: predictive factors and surgical outcomes. Gen Thorac Cardiovasc Surg 2019; 67: 773\u201381.","DOI":"10.1007\/s11748-019-01076-9"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Towe CW, Worrell SG, Bachman K, et al. Neoadjuvant treatment is associated with superior outcomes in T4 lung cancers with local extension. Ann Thorac Surg 2021; 111: 448\u201355.","DOI":"10.1016\/j.athoracsur.2020.05.084"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Sato H, Toyooka S, Soh J, et al. Advantage of Induction Chemoradiotherapy for Lung Cancer in Securing Cancer-Free Bronchial Margin. Ann Thorac Surg 2017; 104: 971\u20138.","DOI":"10.1016\/j.athoracsur.2017.03.045"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Mollberg NM, Bennette C, Howell E, et al. Lymphovascular invasion as a prognostic indicator in stage I non-small cell lung cancer: a systematic review and meta-analysis. Ann Thorac Surg 2014; 97: 965\u201371.","DOI":"10.1016\/j.athoracsur.2013.11.002"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Okiror L, Harling L, Toufektzian L, et al. Prognostic factors including lymphovascular invasion on survival for resected non-small cell lung cancer. J Thorac Cardiovasc Surg 2018; 156: 785\u201393.","DOI":"10.1016\/j.jtcvs.2018.02.108"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Kabuto T, Menju T, Nishikawa S, et al. Pathological features and differential efficacy of cisplatin-based adjuvant chemotherapy in lung cancer harboring epidermal growth factor receptor mutations. Ann Thorac Cardiovasc Surg 2025; 31: 24-00149.","DOI":"10.5761\/atcs.oa.24-00149"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant 2013; 48: 452\u20138.","DOI":"10.1038\/bmt.2012.244"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kim S, Huh JW, Lee WY, et al. Lymphovascular invasion, perineural invasion, and tumor budding are prognostic factors for stage I colon cancer recurrence. Int J Colorectal Dis 2020; 35: 881\u20135.","DOI":"10.1007\/s00384-020-03548-4"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Rakha EA, Martin S, Lee AH, et al. The prognostic significance of lymphovascular invasion in invasive breast carcinoma. Cancer 2012; 118: 3670\u201380.","DOI":"10.1002\/cncr.26711"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Zhou J, Yang Y, Zhang H, et al. Lymphovascular and perineural invasion after neoadjuvant therapy in esophageal squamous carcinoma. Ann Thorac Surg 2023; 115: 1386\u201394.","DOI":"10.1016\/j.athoracsur.2022.07.052"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kutlay C, G\u00fclhan S\u015eE, Acar LN, et al. Impact of spread through air spaces (STAS) and lymphovascular invasion (LVI) on prognosis in NSCLC: a comprehensive pathological evaluation. Updates Surg 2025; 77: 1205\u201313.","DOI":"10.1007\/s13304-025-02170-9"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Zhao Y, Wang R, Shen X, et al. Minor components of micropapillary and solid subtypes in lung adenocarcinoma are predictors of lymph node metastasis and poor prognosis. Ann Surg Oncol 2016; 23: 2099\u2013105.","DOI":"10.1245\/s10434-015-5043-9"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Wakelee H, Liberman M, Kato T, et al. Perioperative pembrolizumab for early-stage non-small-cell lung cancer. N Engl J Med 2023; 389: 491\u2013503.","DOI":"10.1056\/NEJMoa2302983"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Nomori H, Shiraishi A, Honma K, et al. Differences between lung adenocarcinoma and squamous cell carcinoma in histological distribution of residual tumor after induction chemoradiotherapy. Discov Oncol 2021; 12: 36.","DOI":"10.1007\/s12672-021-00431-8"}],"container-title":["Annals of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/atcs\/32\/1\/32_oa.25-00242\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:37:09Z","timestamp":1783139829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/atcs\/32\/1\/32_oa.25-00242\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5761\/atcs.oa.25-00242","relation":{},"ISSN":["1341-1098","2186-1005"],"issn-type":[{"value":"1341-1098","type":"print"},{"value":"2186-1005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"oa.25-00242"}}