{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:57:51Z","timestamp":1771232271140,"version":"3.50.1"},"reference-count":81,"publisher":"IntechOpen","isbn-type":[{"value":"9781839689321","type":"print"},{"value":"9781839689338","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>This chapter is intended to describe the main antioxidants used in the design and construction of functional foods. Defining the role of antioxidants, in the main redox processes in which certain oxidoreductases are involved, the best way of monitoring the activity of certain coenzymes of these oxidoreductases, will be established the main criteria in the design of sustainable functional foods. In addition, the importance of some coenzymes (FMN, FMNH + H +, NAD, NADH + H+) in preserving the activity of some valuable bio-compounds (with the role of antioxidants) in functional foods will be highlighted. Antioxidants are good disease-fighters, protecting our bodies from free radicals\u2019 attacks that would otherwise damage of the human cellular structures. Knowing and supporting the activity of the main compounds (with antioxidant activity) are operations that improve the reaction mechanisms of redox processes and can significantly contribute to achieving good functional foods - able to regulate the acid\u2013base balance of the body and improve the metabolic processes from the consumer body.<\/jats:p>","DOI":"10.5772\/intechopen.97364","type":"book-chapter","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T14:25:57Z","timestamp":1619619957000},"source":"Crossref","is-referenced-by-count":7,"title":["Natural Compounds with Antioxidant Activity-Used in the Design of Functional Foods"],"prefix":"10.5772","author":[{"given":"Petre","family":"S\u0103vescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3774","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"ref=1","doi-asserted-by":"crossref","unstructured":"Bayani Uttara, Ajay V. Singh, Paolo Zamboni, R.T Mahajan, 2009, Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options, Curr Neuropharmacol.; 7(1): 65\u201374. doi: 10.2174\/157015909787602823","DOI":"10.2174\/157015909787602823"},{"key":"ref=2","doi-asserted-by":"crossref","unstructured":"Savescu, P.; Iacobescu, F.; Poenaru M.M. Study on the use of biomaterials as protective membranes for certain functional foods, Book: Advances in Bionanomaterials II \u2013 Selected Papers from the 3rd International Conference on Bio and Nanomaterials, BIONAM 2019, Book Series: Lecture Notes in Bioengineering. Publisher: Springer International Publishing, Print ISBN: 978-3-030-47704-2, Springer Nature Switzerland AG 2020, S. Piotto et al. (Eds.): BIONAM 2019, LNBE, 2020, 178\u2013190","DOI":"10.1007\/978-3-030-47705-9_16"},{"key":"ref=3","doi-asserted-by":"crossref","unstructured":"Di Meo, S.; Venditti, P. Evolution of the knowledge on free radicals and other oxidants. In Oxidative Medicine and Cellular Longevity; Hindawi: London, UK, 2020; p. 32-36","DOI":"10.1155\/2020\/9829176"},{"key":"ref=4","doi-asserted-by":"crossref","unstructured":"Forman, H.J.; Davies, K.J.; Ursini, F. How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic. Biol. Med. 2014, 66, 24\u201335","DOI":"10.1016\/j.freeradbiomed.2013.05.045"},{"key":"ref=5","unstructured":"Savescu P., Badescu G., Milut M., Ciobanu A., Apostol L., Vladut V., 2019. Healthy Food \u2013 Through Innovative Technologies. Vol. ISB-INMA-TEH 2019 INTERNATIONAL SYMPOSIUM Bucharest. 2019, p.2048-2053"},{"key":"ref=6","doi-asserted-by":"crossref","unstructured":"Belenky, P.; Bogan, KL.; Brenne,r C.,2007. NAD+metabolism in health and disease. Trends Biochem. Sci. 32 (1): 2007, 12\u201319","DOI":"10.1016\/j.tibs.2006.11.006"},{"key":"ref=7","doi-asserted-by":"crossref","unstructured":"Apleblat, Alexander (2014). Citric acid. Springer. ISBN 978-3-319-11232-9","DOI":"10.1007\/978-3-319-11233-6"},{"key":"ref=8","unstructured":"https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfcfr\/ CFRSearch.cfm?fr=184.1033, accessed in dec,12,2020"},{"key":"ref=9","unstructured":"https:\/\/efsa.onlinelibrary.wiley.com\/doi\/pdf\/10.2903\/j.efsa.2015.4010"},{"key":"ref=10","unstructured":"Citric acid, FDA, 21CFR184.1033, https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfCFR\/CFRSearch.cfm?fr=184.1033, Commission Regulation (EU) No 1129\/2011 of 11 November 2011 amending Annex II to Regulation (EC) No 1333\/2008 of the E.P. and of the Council by establishing a Union list of food additives"},{"key":"ref=11","unstructured":"Chen, X., Lv, Q., Liu, Y., Deng, W. (2017). Effect of Food Additive Citric Acid on The Growth of Human Esophageal Carcinoma Cell Line EC109. Cell journal, 18(4), 493\u2013502. https:\/\/doi.org\/10.22074\/cellj.2016.4716"},{"key":"ref=12","unstructured":"Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway, Nature, 2017, (https:\/\/www.nature.com\/articles\/s41598-017-04626-4)"},{"key":"ref=13","unstructured":"Report on Carcinogens, USA, Fourteenth Edition, USA, 2016"},{"key":"ref=14","doi-asserted-by":"crossref","unstructured":"Wang W, Kannan K. Quantitative identification of and exposure to synthetic phenolic antioxidants, including butylated hydroxytoluene, in urine. Environ Int. 2019 Jul;128:24-29. doi: 10.1016\/j.envint.2019.04.028. Epub 2019 Apr 25. PMID: 31029976; PMCID: PMC6526070","DOI":"10.1016\/j.envint.2019.04.028"},{"key":"ref=15","doi-asserted-by":"crossref","unstructured":"Williams GM, Iatropoulos MJ, Whysner J. Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives. Food Chem Toxicol. 1999 Sep-Oct;37(9-10):1027-38. doi: 10.1016\/s0278-6915(99)00085-x. PMID: 10541460","DOI":"10.1016\/S0278-6915(99)00085-X"},{"key":"ref=16","unstructured":"Helmenstine, Anne Marie, Ph.D. \"Chemistry of BHA and BHT Food Preservatives.\" ThoughtCo, Aug. 28, 2020, thoughtco.com\/bha-and-bht-food-preservatives-607393"},{"key":"ref=17","doi-asserted-by":"crossref","unstructured":"Ito N, Fukushima S, Tsuda H. Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants. Crit Rev Toxicol. 1985;15(2):109-50. doi: 10.3109\/10408448509029322. PMID: 3899519","DOI":"10.3109\/10408448509029322"},{"key":"ref=18","unstructured":"https:\/\/eur-lex.europa.eu\/legal-content\/RO\/TXT\/PDF\/?uri=CELEX:32018R1481&from=EN"},{"key":"ref=19","unstructured":"Blaner WS (2020). \"Vitamin A\". In BP Marriott, DF Birt, VA Stallings, AA Yates (eds.). Present Knowledge in Nutrition, Eleventh Edition. London, United Kingdom: Academic Press (Elsevier). pp. 73\u201392. ISBN 978-0-323-66162-1"},{"key":"ref=20","unstructured":"Vitamin A. Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis. January 2015"},{"key":"ref=21","unstructured":"Fennema O (2008). Fennema's Food Chemistry. CRC Press\/Taylor & Francis. pp. 454\u2013455. ISBN 9780849392726"},{"key":"ref=22","unstructured":"Blaner WS (2020). \"Vitamin A\". In BP Marriott, DF Birt, VA Stallings, AA Yates (eds.). Present Knowledge in Nutrition, Eleventh Edition. London, United Kingdom: Academic Press (Elsevier). pp. 73\u201392. ISBN 978-0-323-66162-1"},{"key":"ref=23","unstructured":"Vitamin A. 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PMID 21715511","DOI":"10.3945\/ajcn.110.005777"},{"key":"ref=27","unstructured":"Meschino (2013), Health. \"Comprehensive Guide to Vitamin A\""},{"key":"ref=28","unstructured":"Vitamin A. MedlinePlus, National Library of Medicine, US National Institutes of Health. 2 December 2016"},{"key":"ref=29","unstructured":"British Cancer Organization Calls for Warning Labels on Beta-Carotene. 2000-07-31"},{"key":"ref=30","doi-asserted-by":"crossref","unstructured":"The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994). \"The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers\". N Engl J Med. 330 (15): 1029\u201335","DOI":"10.1056\/NEJM199404143301501"},{"key":"ref=31","doi-asserted-by":"crossref","unstructured":"Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2007). \"Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis\". JAMA. 297 (8): 842\u201357. doi:10.1001\/jama.297.8.842","DOI":"10.1001\/jama.297.8.842"},{"key":"ref=32","doi-asserted-by":"crossref","unstructured":"Yanagi, Kazuhiro; Iakoubovskii, Konstantin; Kazaoui, Said; Minami, Nobutsugu; Maniwa, Yutaka; Miyata, Yasumitsu; Kataura, Hiromichi (2006). Light-Harvesting Function of \u03b2-Carotene Inside Carbon Nanotubes (PDF). Phys. Rev. B. 74 (15): 155420.","DOI":"10.1103\/PhysRevB.74.155420"},{"key":"ref=33","doi-asserted-by":"crossref","unstructured":"Ma L, Dou HL, Wu YQ, Huang YM, Huang YB, Xu XR, Zou ZY, Lin XM. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Br J Nutr. 2012 Feb;107(3):350-9. doi: 10.1017\/S0007114511004260. Epub 2011 Sep 8. PMID: 21899805","DOI":"10.1017\/S0007114511004260"},{"key":"ref=34","doi-asserted-by":"crossref","unstructured":"Traber MG, Bruno RS (2020). \"Vitamin E\". In BP Marriott, DF Birt, VA Stallings, AA Yates (eds.). Present Knowledge in Nutrition, Eleventh Edition. London, United Kingdom: Academic Press (Elsevier). pp. 115\u201336. ISBN 978-0-323-66162-1","DOI":"10.1016\/B978-0-323-66162-1.00007-X"},{"key":"ref=35","doi-asserted-by":"crossref","unstructured":"Saito, Yuika; Yanagi, Kazuhiro; Hayazawa, Norihiko; Ishitobi, Hidekazu; Ono, Atsushi; Kataura, Hiromichi; Kawata, Satoshi (2006). \"Vibrational Analysis of Organic Molecules Encapsulated in Carbon Nanotubes by Tip-Enhanced Raman Spectroscopy\". Jpn. J. Appl. Phys. 45 (12): 9286\u20139289. Bibcode:2006JaJAP.45.9286S. doi:10.1143\/JJAP.45.9286","DOI":"10.1143\/JJAP.45.9286"},{"key":"ref=36","doi-asserted-by":"crossref","unstructured":"Scientific Opinion on the substantiation of health claims related to lycopene and protection of DNA, proteins and lipids from oxidative damage protection of the skin from UV-induced (including photo-oxidative) damage, contribution to normal cardiac function, and maintenance of normal vision pursuant to Article 13(1) of Regulation (EC) No 1924\/2006\". EFSA Journal. 9 (4): 2031. 2011. doi:10.2903\/j.efsa.2011.2031","DOI":"10.2903\/j.efsa.2011.2031"},{"key":"ref=37","doi-asserted-by":"crossref","unstructured":"Ilahy, R; Piro, G; Tlili, I; Riahi, A; Sihem, R; Ouerghi, I; Hdider, C; Lenucci, M. S. (2016). \"Fractionate analysis of the phytochemical composition and antioxidant activities in advanced breeding lines of high-lycopene tomatoes\". Food Funct. 7 (1): 574\u201383. doi:10.1039\/c5fo00553a","DOI":"10.1039\/C5FO00553A"},{"key":"ref=38","unstructured":"Carotenoids: \u03b1-Carotene, \u03b2-Carotene, \u03b2-Cryptoxanthin, Lycopene, Lutein, and Zeaxanthin. Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. July 2016"},{"key":"ref=39","unstructured":"Perdomo F, Cabrera Fr\u00e1nquiz F, Cabrera J, Serra-Majem L (2012). \"Influence of cooking procedure on the bioavailability of lycopene in tomatoes\". Hospital Nutrition (Madrid). 27 (5): 1542\u20136. doi:10.3305\/nh.2012.27.5.5908"},{"key":"ref=40","doi-asserted-by":"crossref","unstructured":"Kamiloglu, S.; Demirci, M.; Selen, S.; Toydemir, G.; Boyacioglu, D.; Capanoglu, E. (2014). Home processing of tomatoes (Solanum lycopersicum): Effects on in vitro-bio-accessibility of total lycopene, phenolics, flavonoids, and antioxidant capacity. Journal of the Science of Food and Agriculture. 94 (11): 2225\u201333. doi:10.1002\/jsfa.6546","DOI":"10.1002\/jsfa.6546"},{"key":"ref=41","unstructured":"Yamaguchi, Masayoshi (2010). Carotenoids: Properties, Effects and Diseases. New York: Nova Science Publishers. p. 125. ISBN 9781612097138"},{"key":"ref=42","doi-asserted-by":"crossref","unstructured":"Maria Alessandra Gammone, Graziano Riccioni, Nicolantonio D'Orazio (2015). Carotenoids: potential allies of cardiovascular health? Food Nutr Res. 2015; 59: 10.3402\/fnr.v59.26762. DOI: 10.3402\/fnr.v59.26762","DOI":"10.3402\/fnr.v59.26762"},{"key":"ref=43","doi-asserted-by":"crossref","unstructured":"Shahidi F, de Camargo AC (October 2016). Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits. International Journal of Molecular Sciences. 17 (10):1745. doi:10.3390\/ijms17101745. PMC 5085773","DOI":"10.3390\/ijms17101745"},{"key":"ref=44","doi-asserted-by":"crossref","unstructured":"Reboul E, Richelle M, Perrot E, Desmoulins-Malezet C, Pirisi V, Borel P (November 2006). \"Bioaccessibility of carotenoids and vitamin E from their main dietary sources\". Journal of Agricultural and Food Chemistry. 54 (23): 8749\u201355. doi:10.1021\/jf061818s","DOI":"10.1021\/jf061818s"},{"key":"ref=45","doi-asserted-by":"crossref","unstructured":"Wefers H, Sies H (June 1988). The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E. European Journal of Biochemistry. 174 (2): 353\u20137. doi:10.1111\/j.1432-1033.1988.tb14105.x","DOI":"10.1111\/j.1432-1033.1988.tb14105.x"},{"key":"ref=46","unstructured":"Manolescu B, Atanasiu V, Cercasov C, Stoian I, Oprea E, Bu\u015fu C (2008). So many options but one choice: the human body prefers alpha-tocopherol. A matter of stereochemistry. Journal of Medicine and Life. 1 (4): 376\u201382. PMC 5654212. PMID 20108516"},{"key":"ref=47","doi-asserted-by":"crossref","unstructured":"Traber MG, Atkinson J (July 2007). Vitamin E, antioxidant and nothing more. Free Radical Biology & Medicine. 43 (1): 4\u201315. doi:10.1016\/j.freeradbiomed.2007.03.024","DOI":"10.1016\/j.freeradbiomed.2007.03.024"},{"key":"ref=48","doi-asserted-by":"crossref","unstructured":"Wang X, Quinn PJ (July 1999). \"Vitamin E and its function in membranes\". Progress in Lipid Research. 38 (4): 309\u201336. doi:10.1016\/S0163-7827(99)00008-9. PMID 10793887","DOI":"10.1016\/S0163-7827(99)00008-9"},{"key":"ref=49","doi-asserted-by":"crossref","unstructured":"Kirmizis D, Chatzidimitriou D (2009). \"Antiatherogenic effects of vitamin E: the search for the Holy Grail\". Vascular Health and Risk Management. 5: 767\u201374. doi:10.2147\/vhrm.s5532. PMC 2747395. PMID 19774218","DOI":"10.2147\/VHRM.S5532"},{"key":"ref=50","doi-asserted-by":"crossref","unstructured":"Evans JR, Lawrenson JG (July 2017). \"Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration\". The Cochrane Database of Systematic Reviews. 7: CD000254. doi:10.1002\/14651858.CD000254.pub4. PMC 6483465","DOI":"10.1002\/14651858.CD000253.pub4"},{"key":"ref=51","unstructured":"Vitamin C. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: The National Academies Press. 2000. pp. 95\u2013185. ISBN 978-0-309-06935-9"},{"key":"ref=52","unstructured":"Vitamin C. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: The National Academies Press. 2000. pp. 95\u2013185. ISBN 978-0-309-06935-9"},{"key":"ref=53","doi-asserted-by":"crossref","unstructured":"Fritz H, Flower G, Weeks L, Cooley K, Callachan M, McGowan J, Skidmore B, Kirchner L, Seely D (July 2014). \"Intravenous Vitamin C and Cancer: A Systematic Review\". Integrative Cancer Therapies. 13 (4): 280\u2013300. doi:10.1177\/1534735414534463. PMID 24867961","DOI":"10.1177\/1534735414534463"},{"key":"ref=54","doi-asserted-by":"crossref","unstructured":"Du J, Cullen JJ, Buettner GR (December 2012). \"Ascorbic acid: chemistry, biology and the treatment of cancer\". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1826 (2): 443\u201357. doi:10.1016\/j.bbcan.2012.06.003. PMID 22728050","DOI":"10.1016\/j.bbcan.2012.06.003"},{"key":"ref=55","doi-asserted-by":"crossref","unstructured":"Ye Y, Li J, Yuan Z (2013). \"Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials\". PLOS ONE. 8 (2): e56803. Bibcode:2013PLoSO...856803Y. doi:10.1371\/journal.pone.0056803","DOI":"10.1371\/journal.pone.0056803"},{"key":"ref=56","doi-asserted-by":"crossref","unstructured":"Gallie DR., 2013. \"L-ascorbic Acid: a multifunctional molecule supporting plant growth and development\". Scientifica. 2013: 1\u201324. doi:10.1155\/2013\/795964. PMC 3820358. PMID 24278786","DOI":"10.1155\/2013\/795964"},{"key":"ref=57","unstructured":"Flavonoids: chemistry, biochemistry, and applications. Andersen, \u00d8yvind M., Markham, Kenneth R. CRC, Taylor & Francis. 2006. ISBN 0849320216"},{"key":"ref=58","doi-asserted-by":"crossref","unstructured":"Galli F, Azzi A, Birringer M, Cook-Mills JM, Eggersdorfer M, Frank J, et al. (January 2017). \"Vitamin E: Emerging aspects and new directions\". Free Radical Biology & Medicine. 102: 16\u201336. doi: 10.1016\/j.freeradbiomed.2016.09.017","DOI":"10.1016\/j.freeradbiomed.2016.09.017"},{"key":"ref=59","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)2, 3 European Food Safety Authority (EFSA), Parma, Italy (2010). Scientific Opinion on the substantiation of health claims related to various food(s)\/food constituent(s) and protection of cells from premature aging, antioxidant activity, antioxidant content and antioxidant properties, and protection of DNA, proteins and lipids from oxidative damage pursuant to Article 13(1) of Regulation (EC) No 1924\/20061. EFSA Journal. 8 (2): 1489. doi:10.2903\/j.efsa.2010.1489","DOI":"10.2903\/j.efsa.2010.1489"},{"key":"ref=60","doi-asserted-by":"crossref","unstructured":"Cermak R, Wolffram S (October 2006). \"The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms\". Curr. Drug Metab. 7 (7): 729\u201344. doi:10.2174\/138920006778520570. PMID 17073577","DOI":"10.2174\/138920006778520570"},{"key":"ref=61","unstructured":"Flavone. ChemSpider, Royal Society of Chemistry. 2015"},{"key":"ref=62","unstructured":"Flavanones, Webster's New World College Dictionary (Fifth ed.), Houghton Mifflin Harcourt Publishing Company, 2014"},{"key":"ref=63","doi-asserted-by":"crossref","unstructured":"Kaufman PB, Duke JA, Brielmann H, Boik J, Hoyt JE (1997). \"A comparative survey of leguminous plants as sources of the isoflavones, genistein and daidzein: implications for human nutrition and health\". J Altern Complement Med. 3 (1): 7\u201312. CiteSeerX 10.1.1.320.9747. doi:10.1089\/acm.1997.3.7","DOI":"10.1089\/acm.1997.3.7"},{"key":"ref=64","doi-asserted-by":"crossref","unstructured":"Heber, D (2008). \"Plant Foods and PhyTOChemicals in Human Health\". In Berdanier, C.D; Dwyer, J.T.; Feldman, E.B. (eds.). Handbook of Nutrition and Food, Second Edition. CRC Press. pp. 176\u2013181. doi:10.1201\/9781420008890.ch70. ISBN 978-0-8493-9218-4","DOI":"10.1201\/9781420008890.ch70"},{"key":"ref=65","unstructured":"Soy. MedlinePlus, US National Library of Medicine"},{"key":"ref=66","doi-asserted-by":"crossref","unstructured":"Varinska L, Gal P, Mojzisova G, Mirossay L, Mojzis J (2015). \"Soy and breast cancer: focus on angiogenesis\". Int J Mol Sci (Review). 16 (5): 11728\u201349. doi:10.3390\/ijms160511728. PMC 4463727","DOI":"10.3390\/ijms160511728"},{"key":"ref=67","doi-asserted-by":"crossref","unstructured":"Wei, P; Liu, M; Chen, Y; Chen, D. C. (2012). \"Systematic review of soy isoflavone supplements on osteoporosis in women\". Asian Pacific Journal of Tropical Medicine. 5 (3): 243\u20138. doi:10.1016\/S1995-7645(12)60033-9","DOI":"10.1016\/S1995-7645(12)60033-9"},{"key":"ref=68","unstructured":"Lipoic acid. Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis"},{"key":"ref=69","doi-asserted-by":"crossref","unstructured":"Haenen, GRMM; Bast, A (1991). \"Scavenging of hypochlorous acid by lipoic acid\". Biochemical Pharmacology. 42 (11): 2244\u20136. doi:10.1016\/0006-2952(91)90363-A","DOI":"10.1016\/0006-2952(91)90363-A"},{"key":"ref=70","doi-asserted-by":"crossref","unstructured":"Shay, KP; Moreau, RF; Smith, EJ; Hagen, TM (June 2008). \"Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity\". IUBMB Life. 60 (6): 362\u20137. doi:10.1002\/iub.40. PMID 18409172","DOI":"10.1002\/iub.40"},{"key":"ref=71","doi-asserted-by":"crossref","unstructured":"Shay, KP; Moreau, RF; Smith, EJ; Smith, AR; et al. (October 2009). \"Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential\". Biochimica et Biophysica Acta. 1790 (10): 1149\u201360. doi: 10.1016\/j.bbagen.2009.07.026. PMC 2756298","DOI":"10.1016\/j.bbagen.2009.07.026"},{"key":"ref=72","unstructured":"Shay, KP; Shenvi, S; Hagen, TM. \"Ch. 14 Lipoic Acid as an Inducer of Phase II Detoxification Enzymes Through Activation of Nr-f2 Dependent Gene Expression\". Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. pp. 349\u201371. In Packer & Patel 2008"},{"key":"ref=73","doi-asserted-by":"crossref","unstructured":"Ebisch IM, Thomas CM, Peters WH, Braat DD, Steegers-Theunissen RP (March\u2013April 2007). \"The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility\". Human Reproduction Update. 13 (2): 163\u201374. doi:10.1093\/humupd\/dml054","DOI":"10.1093\/humupd\/dml054"},{"key":"ref=74","doi-asserted-by":"crossref","unstructured":"Nomenclature and symbolism for amino acids and peptides (IUPAC-IUB Recommendations 1983), Pure Appl. Chem., 56 (5): 595\u2013624, 1984, doi:10.1351\/pac198456050595","DOI":"10.1351\/pac198456050595"},{"key":"ref=75","unstructured":"The primary structure of proteins is the amino acid sequence. The Microbial World. University of Wisconsin-Madison Bacteriology Department"},{"key":"ref=76","unstructured":"Belitz, H.-D; Grosch, Werner; Schieberle, Peter (2009-02-27). Food Chemistry. ISBN 9783540699330"},{"key":"ref=77","doi-asserted-by":"crossref","unstructured":"Sekhar, Rajagopal V; Patel, Sanjeet G (2011). \"Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation\". The American Journal of Clinical Nutrition. 94 (3): 847\u2013853. doi:10.3945\/ajcn.110.003483. PMC 3155927. PMID 21795440","DOI":"10.3945\/ajcn.110.003483"},{"key":"ref=78","doi-asserted-by":"crossref","unstructured":"Michael Brownlee (2005). The pathobiology of diabetic complications: A unifying mechanism. Diabetes. 54 (6): 1615\u201325. doi:10.2337\/diabetes.54.6.1615. PMID 15919781","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"ref=79","doi-asserted-by":"crossref","unstructured":"Guoyao Wu, Yun-Zhong Fang, Sheng Yang, Joanne R. Lupton, Nancy D. Turner (2004). Glutathione Metabolism and its Implications for Health. Journal of Nutrition. 134 (3): 489\u201392. doi:10.1093\/jn\/134.3.489. PMID 14988435","DOI":"10.1093\/jn\/134.3.489"},{"key":"ref=80","doi-asserted-by":"crossref","unstructured":"Dringen R.,2000. \"Metabolism and functions of glutathione in brain\". Progress in Neurobiology. 62 (6): 649\u201371. doi:10.1016\/s0301-0082(99)00060-x. PMID 10880854. S2CID 452394","DOI":"10.1016\/S0301-0082(99)00060-X"},{"key":"ref=81","doi-asserted-by":"crossref","unstructured":"Scholz, RW. Graham KS. Gumpricht E. Reddy CC. (1989). \"Mechanism of interaction of vitamin E and glutathione in the protection against membrane lipid peroxidation\". Ann NY Acad Sci. 570 (1): 514\u20137. 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