{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:18:27Z","timestamp":1789802307263,"version":"4.0.1"},"reference-count":50,"publisher":"The Japanese Society for Neuroendovascular Therapy","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NOUSHINKEI KEKKANNAI TIRYOU","JNET"],"published-print":{"date-parts":[[2023]]},"DOI":"10.5797\/jnet.ra.2023-0056","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T22:53:11Z","timestamp":1696546391000},"page":"272-280","source":"Crossref","is-referenced-by-count":12,"title":["Cancer-Associated Stroke and Acute Endovascular Reperfusion Therapy"],"prefix":"10.5797","volume":"17","author":[{"given":"Mikito","family":"Hayakawa","sequence":"first","affiliation":[{"name":"Department of Stroke and Cerebrovascular Diseases, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan"},{"name":"Department of Neurology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3804","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. <i>N Engl J Med<\/i> 2015; 372: 11\u201320.","DOI":"10.1056\/NEJMx140064"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. <i>N Engl J Med<\/i> 2015; 372: 1019\u20131030.","DOI":"10.1056\/NEJMoa1414905"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. <i>N Engl J Med<\/i> 2015; 372: 1009\u20131018.","DOI":"10.1056\/NEJMoa1414792"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. <i>N Engl J Med<\/i> 2015; 372: 2285\u20132295.","DOI":"10.1056\/NEJMoa1415061"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Jovin TG, Chamorro A, Cobo E, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. <i>N Engl J Med<\/i> 2015; 372: 2296\u20132306.","DOI":"10.1056\/NEJMoa1503780"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Shapiro SD, Vazquez S, Das A, et al. Investigating outcomes post endovascular thrombectomy in acute stroke patients with cancer. <i>Neurology<\/i> 2022; 19 [Epub ahead of print.","DOI":"10.1212\/WNL.0000000000201208"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Caimano D, Letteri F, Capasso F, et al. Endovascular treatment in patients with acute ischemic stroke and cancer: systematic review and meta-analysis. <i>Eur Stroke J<\/i> 2022; 7: 204\u2013211.","DOI":"10.1177\/23969873221100897"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Jhou HJ, Yang LY, Chen PH, et al. Endovascular therapy for acute ischemic stroke in patients with active malignancy: a meta-analysis with trial sequential analysis. <i>J Neurointerv Surg<\/i> 2023; 15: e154\u2013e160.","DOI":"10.1136\/jnis-2022-019489"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Varki A. Trousseau\u2019s syndrome: multiple definitions and multiple mechanisms. <i>Blood<\/i> 2007; 110: 1723\u20131729.","DOI":"10.1182\/blood-2006-10-053736"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Mukai M, Oka T. Mechanism and management of cancer-associated thrombosis. <i>J Cardiol<\/i> 2018; 72: 89\u201393.","DOI":"10.1016\/j.jjcc.2018.02.011"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Navi BB, Iadecola C. Ischemic stroke in cancer patients: a review of an underappreciated pathology. <i>Ann Neurol<\/i> 2018; 83: 873\u2013883.","DOI":"10.1002\/ana.25227"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Costamagna G, Hottinger A, Milionis H, et al. Clinical and demographic characteristics, mechanisms, and outcomes in patients with acute ischemic stroke and newly diagnosed or known active cancer. <i>Neurology<\/i> 2023; 100: e2477\u2013e2489.","DOI":"10.1212\/WNL.0000000000207341"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Usui G, Takayama Y, Hashimoto H, et al. Cerebral embolism caused by thrombus in the pulmonary vein stump after left lower lobectomy: a case report and literature review. <i>Intern Med<\/i> 2019; 58: 1349\u20131354.","DOI":"10.2169\/internalmedicine.1962-18"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Riddersholm S, Tayal B, Kragholm K, et al. Incidence of stroke after pneumonectomy and lobectomy. <i>Stroke<\/i> 2019; 50: 1052\u20131059.","DOI":"10.1161\/STROKEAHA.118.024496"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kim SG, Hong JM, Kim HY, et al. Ischemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea. <i>Stroke<\/i> 2010; 41: 798\u2013801.","DOI":"10.1161\/STROKEAHA.109.571356"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Lee D, Lee DH, Suh DC, et al. Intra-arterial thrombectomy for acute ischaemic stroke patients with active cancer. <i>J Neurol<\/i> 2019; 266: 2286\u20132293.","DOI":"10.1007\/s00415-019-09416-8"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Sallustio F, Mascolo AP, Marrama F, et al. Safety and efficacy of reperfusion therapies for acute ischemic stroke patients with active malignancy. <i>J Stroke Cerebrovasc Dis<\/i> 2019; 28: 2287\u20132291.","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.05.018"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Cho BH, Yoon W, Kim JT, et al. Outcomes of endovascular treatment in acute ischemic stroke patients with current malignancy. <i>Neurol Sci<\/i> 2020; 41: 379\u2013385.","DOI":"10.1007\/s10072-019-04103-y"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Ozaki T, Nicholson P, Schaafsma JD, et al. Endovascular therapy of acute ischemic stroke in patients with large-vessel occlusion associated with active malignancy. <i>J Stroke Cerebrovasc Dis<\/i> 2021; 30: 105455.","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105455"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Yoo J, Kim YD, Park H, et al. Immediate and long-term outcomes of reperfusion therapy in patients with cancer. <i>Stroke<\/i> 2021; 52: 2026\u20132034.","DOI":"10.1161\/STROKEAHA.120.032380"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Ciolli L, Bigliardi G, Ferraro D, et al. Efficacy of mechanical thrombectomy in patients with ischemic stroke and cancer. <i>J Clin Neurosci<\/i> 2021; 91: 20\u201322.","DOI":"10.1016\/j.jocn.2021.06.029"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Joshi KC, Grewal P, Beer-Furlan A, et al. Endovascular thrombectomy for acute ischemic stroke in patients with cancer: a propensity-matched analysis. <i>J Neurointerv Surg<\/i> 2022; 14: 1161\u20131165.","DOI":"10.1136\/neurintsurg-2021-018211"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Verschoof MA, Groot AE, de Bruijn SFTM, et al. Clinical outcome after endovascular treatment in patients with active cancer and ischemic stroke: a MR CLEAN Registry Substudy. <i>Neurology<\/i> 2022; 98: e993\u2013e1001.","DOI":"10.1212\/WNL.0000000000013316"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Mattingly TK, Risco JE, Burch JE, et al. Endovascular therapy is effective for large vessel occlusion despite concurrent cancer. <i>J Stroke Cerebrovasc Dis<\/i> 2022; 31: 106439.","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106439"},{"key":"25","unstructured":"25) Federica L, Giovanni P, Valentina S, et al. Endovascular treatment in patients with acute ischemic stroke and comorbid cancer: analysis of the Italian Registry of Endovascular Treatment in Acute Stroke. <i>Stroke Vasc Interv Neurol<\/i> 2023; 3: e000423."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Jung S, Jung C, Hyoung Kim J, et al. Procedural and clinical outcomes of endovascular recanalization therapy in patients with cancer-related stroke. <i>Interv Neuroradiol<\/i> 2018; 24: 520\u2013528.","DOI":"10.1177\/1591019918776207"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Lee EJ, Bae J, Jeong HB, et al. Effectiveness of mechanical thrombectomy in cancer-related stroke and associated factors with unfavorable outcome. <i>BMC Neurol<\/i> 2021; 21: 57.","DOI":"10.1186\/s12883-021-02086-y"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Aboul-Nour H, Maraey A, Jumah A, et al. Mechanical thrombectomy for acute ischemic stroke in metastatic cancer patients: a nationwide cross-sectional analysis. <i>J Stroke<\/i> 2023; 25: 119\u2013125.","DOI":"10.5853\/jos.2022.02334"},{"key":"29","unstructured":"29) Shiozawa M, Hayakawa M, Miyazaki Y, et al. A case of acute ischemic stroke comorbid with advanced cancer who underwent mechanical thrombectomy. <i>No to Junkan<\/i> 2017; 22: 57\u201363 (in Japanese)."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Kuroda N, Hiramatsu H, Mori M, et al. Mechanical thrombectomy for trousseau syndrome in a terminally ill cancer patient. <i>J Pain Symptom Manage<\/i> 2019; 57: 688\u2013694.","DOI":"10.1016\/j.jpainsymman.2018.12.327"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Park H, Kim J, Ha J, et al. Histological features of intracranial thrombi in stroke patients with cancer. <i>Ann Neurol<\/i> 2019; 86: 143\u2013149.","DOI":"10.1002\/ana.25495"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Fu CH, Chen CH, Lin YH, et al. Fibrin and platelet-rich composition in retrieved thrombi hallmarks stroke with active cancer. <i>Stroke<\/i> 2020; 51: 3723\u20133727.","DOI":"10.1161\/STROKEAHA.120.032069"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Kataoka Y, Sonoda K, Takahashi JC, et al. Histopathological analysis of retrieved thrombi from patients with acute ischemic stroke with malignant tumors. <i>J Neurointerv Surg<\/i> 2022; 14: 464\u2013468.","DOI":"10.1136\/neurintsurg-2020-017195"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Hashimoto T, Hayakawa M, Funatsu N, et al. Histopathologic analysis of retrieved thrombi associated with successful reperfusion after acute stroke thrombectomy. <i>Stroke<\/i> 2016; 47: 3035\u20133037.","DOI":"10.1161\/STROKEAHA.116.015228"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Maekawa K, Shibata M, Nakajima H, et al. Erythrocyte-rich thrombus is associated with reduced number of maneuvers and procedure time in patients with acute ischemic stroke undergoing mechanical thrombectomy. <i>Cerebrovasc Dis Extra<\/i> 2018; 8: 39\u201349.","DOI":"10.1159\/000486042"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Shin JW, Jeong HS, Kwon HJ, et al. High red blood cell composition in clots is associated with successful recanalization during intra-arterial thrombectomy. <i>PLoS One<\/i> 2018; 13: e0197492.","DOI":"10.1371\/journal.pone.0197492"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Gunning GM, McArdle K, Mirza M, et al. Clot friction variation with fibrin content; implications for resistance to thrombectomy. <i>J Neurointerv Surg<\/i> 2018; 10: 34\u201338.","DOI":"10.1136\/neurintsurg-2016-012721"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Boodt N, Snouckaert van Schauburg PRW, Hund HM, et al. Mechanical characterization of thrombi retrieved with endovascular thrombectomy in patients with acute ischemic stroke. <i>Stroke<\/i> 2021; 52: 2510\u20132517.","DOI":"10.1161\/STROKEAHA.120.033527"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Jeon Y, Baik SH, Jung C, et al. Mechanical thrombectomy in patients with acute cancer-related stroke: is the stent retriever alone effective? <i>J Neurointerv Surg<\/i> 2021; 13: 318\u2013323.","DOI":"10.1136\/neurintsurg-2020-016144"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Liebeskind DS, Sanossian N, Yong WH, et al. CT and MRI early vessel signs reflect clot composition in acute stroke. <i>Stroke<\/i> 2011; 42: 1237\u20131243.","DOI":"10.1161\/STROKEAHA.110.605576"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Bhambri A, Adapa AR, Liu Y, et al. Thrombus histology as it relates to mechanical thrombectomy: a meta-analysis and systematic review. <i>Neurosurgery<\/i> 2021; 89: 1122\u20131131.","DOI":"10.1093\/neuros\/nyab366"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Kim SK, Yoon W, Kim TS, et al. Histologic analysis of retrieved clots in acute ischemic stroke: correlation with stroke etiology and gradient-echo MRI. <i>AJNR Am J Neuroradiol<\/i> 2015; 36: 1756\u20131762.","DOI":"10.3174\/ajnr.A4402"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Beyeler M, Grunder L, G\u00f6cmen J, et al. Absence of susceptibility vessel sign and hyperdense vessel sign in patients with cancer-related stroke. <i>Front Neurol<\/i> 2023; 14: 1148152.","DOI":"10.3389\/fneur.2023.1148152"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Fitzgerald ST, Wang S, Dai D, et al. Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT. <i>J Neurointerv Surg<\/i> 2019; 11: 1145\u20131149.","DOI":"10.1136\/neurintsurg-2018-014637"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Finelli PF, Nouh A. Three-territory DWI acute infarcts: diagnostic value in cancer-associated hypercoagulation stroke (Trousseau syndrome). <i>AJNR Am J Neuroradiol<\/i> 2016; 37: 2033\u20132036.","DOI":"10.3174\/ajnr.A4846"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Nouh AM, Staff I, Finelli PF. Three territory sign: an MRI marker of malignancy-related ischemic stroke (Trousseau syndrome). <i>Neurol Clin Pract<\/i> 2019; 9: 124\u2013128.","DOI":"10.1212\/CPJ.0000000000000603"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Donati MB. Cancer and thrombosis: from Phlegmasia alba dolens to transgenic mice. <i>Thromb Haemost<\/i> 1995; 74: 278\u2013281.","DOI":"10.1055\/s-0038-1642690"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Key NS, Khorana AA, Kuderer NM, et al. Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO clinical practice guideline update. <i>J Clin Oncol<\/i> 2020; 38: 496\u2013520.","DOI":"10.1200\/JCO.19.01461"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Yamaura G, Ito T, Miyaji Y, et al. Therapeutic efficacy of heparin and direct factor Xa inhibitors in cancer-associated cryptogenic ischemic stroke with venous thromboembolism. <i>Thromb Res<\/i> 2021; 206: 99\u2013103.","DOI":"10.1016\/j.thromres.2021.08.016"},{"key":"50","unstructured":"50) Hayakawa M. Mechanical thrombectomy for cancer-related stroke. Brush-up Seminar of Neuroendovascular Therapy 2021. SHINDAN TO CHIRYO SHA Inc., Tokyo, 2022, 136\u2013141 (in Japanese)."}],"container-title":["Journal of Neuroendovascular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnet\/17\/11\/17_ra.2023-0056\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:37:44Z","timestamp":1715575064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnet\/17\/11\/17_ra.2023-0056\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.5797\/jnet.ra.2023-0056","relation":{},"ISSN":["1882-4072","2186-2494"],"issn-type":[{"value":"1882-4072","type":"print"},{"value":"2186-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"ra.2023-0056"}}