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Flow diverters for treatment of intracranial aneurysms: current status and ongoing clinical trials. <i>J Clin Neurosci<\/i> 2011; 18: 737\u2013740.","DOI":"10.1016\/j.jocn.2010.10.011"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kallmes DF, Ding YH, Dai D, et al. A new endoluminal, flow-disrupting device for treatment of saccular aneurysms. <i>Stroke<\/i> 2007; 38: 2346\u20132352.","DOI":"10.1161\/STROKEAHA.106.479576"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Ravindran K, Salem MM, Alturki AY, et al. Endothelialization following flow diversion for intracranial aneurysms: a systematic review. <i>AJNR Am J Neuroradiol<\/i> 2019; 40: 295\u2013301.","DOI":"10.3174\/ajnr.A5955"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Becske T, Kallmes DF, Saatci I, et al. Pipeline for uncoilable or failed aneurysms: results from a multicenter clinical trial. <i>Radiology<\/i> 2013; 267: 858\u2013868.","DOI":"10.1148\/radiol.13120099"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Nelson PK, Lylyk P, Szikora I, et al. The Pipeline Embolization Device for the intracranial treatment of aneurysms trial. <i>AJNR Am J Neuroradiol<\/i> 2011; 32: 34\u201340.","DOI":"10.3174\/ajnr.A2421"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Becske T, Brinjikji W, Potts MB, et al. Long-term clinical and angiographic outcomes following Pipeline Embolization Device treatment of complex internal carotid artery aneurysms: five-year results of the Pipeline for Uncoilable or Failed Aneurysms trial. <i>Neurosurgery<\/i> 2017; 80: 40\u201348.","DOI":"10.1093\/neuros\/nyw014"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Hanel RA, Kallmes DF, Lopes DK, et al. Prospective Study on Embolization of Intracranial Aneurysms with the Pipeline Device: the PREMIER study 1 year results. <i>J Neurointerv Surg<\/i> 2020; 12: 62\u201366.","DOI":"10.1136\/neurintsurg-2019-015091"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Shigematsu T, Fujinaka T, Yoshimine T, et al. Endovascular therapy for asymptomatic unruptured intracranial aneurysms: JR-NET and JR-NET2 findings. <i>Stroke<\/i> 2013; 44: 2735\u20132742.","DOI":"10.1161\/STROKEAHA.111.000609"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Zhou G, Su M, Yin YL, et al. Complications associated with the use of flow-diverting devices for cerebral aneurysms: a systematic review and meta-analysis. <i>Neurosurg Focus<\/i> 2017; 42: E17.","DOI":"10.3171\/2017.3.FOCUS16450"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Adeeb N, Griessenauer CJ, Moore JM, et al. Ischemic stroke after treatment of Intraprocedural thrombosis during stent-assisted coiling and flow diversion. <i>Stroke<\/i> 2017; 48: 1098\u20131100.","DOI":"10.1161\/STROKEAHA.116.016521"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Bond KM, Brinjikji W, Murad MH, et al. Diffusion-weighted imaging\u2013detected ischemic lesions following endovascular treatment of cerebral aneurysms: a systematic review and meta-analysis. <i>AJNR Am J Neuroradiol<\/i> 2017; 38: 304\u2013309.","DOI":"10.3174\/ajnr.A4989"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Caroff J, King RM, Ughi GJ, et al. Longitudinal monitoring of flow-diverting stent tissue coverage after implant in a bifurcation model using neurovascular high-frequency optical coherence tomography. <i>Neurosurgery<\/i> 2020; 87: 1311\u20131319.","DOI":"10.1093\/neuros\/nyaa208"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Tonetti DA, Jankowitz BT, Gross BA. Antiplatelet therapy in flow diversion. <i>Neurosurgery<\/i> 2020; 86: S47\u2013S52.","DOI":"10.1093\/neuros\/nyz391"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Caroff J, Aubert L, Lavenu-Bombled C, et al. Antithrombotic therapies for neurointerventional surgery: a 2021 French comprehensive national survey. <i>J Neurointerv Surg<\/i> 2023; 15: 402\u2013407.","DOI":"10.1136\/neurintsurg-2021-018601"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Enomoto Y, Matsubara H, Ishihara T, et al. Optimal duration of dual antiplatelet therapy for stent-assisted coiling or flow diverter placement. <i>J Neurointerv Surg<\/i> 2024; 16: 491\u2013498.","DOI":"10.1136\/jnis-2023-020285"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Baik M, Jeon J, Heo SJ, et al. Duration of dual-antiplatelet therapy after stent-assisted coil for unruptured intracranial aneurysm: a nationwide cohort study. <i>Int J Stroke<\/i> 2024; 19: 359\u2013366.","DOI":"10.1177\/17474930231207512"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Saber H, Kherallah RY, Hadied MO, et al. Antiplatelet therapy and the risk of ischemic and hemorrhagic complications associated with Pipeline embolization of cerebral aneurysms: a systematic review and pooled analysis. <i>J Neurointerv Surg<\/i> 2019; 11: 362\u2013366.","DOI":"10.1136\/neurintsurg-2018-014082"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Feigin V, Carter K, Hackett M, et al. Ethnic disparities in incidence of stroke subtypes: Auckland Regional Community Stroke Study, 2002\u20132003. <i>Lancet Neurol<\/i> 2006; 5: 130\u2013139.","DOI":"10.1016\/S1474-4422(05)70325-2"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Kang J, Park KW, Palmerini T, et al. Racial differences in ischaemia\/bleeding risk trade-off during anti-platelet therapy: individual patient level landmark meta-analysis from seven RCTs. <i>Thromb Haemost<\/i> 2019; 119: 149\u2013162.","DOI":"10.1055\/s-0038-1676545"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Yamada K, Imamura H, Ozaki S, et al. A review of current flow diverters. <i>J Neuroendovasc Ther<\/i> 2024; 18: 59\u201364.","DOI":"10.5797\/jnet.ra.2023-0078"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Ravindran K, Casabella AM, Cebral J, et al. Mechanism of action and biology of flow diverters in the treatment of intracranial aneurysms. <i>Neurosurgery<\/i> 2020; 86: S13\u2013S19.","DOI":"10.1093\/neuros\/nyz324"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ravindran K, Salem MM, Alturki AY, et al. Endothelialization following flow diversion for intracranial aneurysms: a systematic review. <i>AJNR Am J Neuroradiol<\/i> 2019; 40: 295\u2013301.","DOI":"10.3174\/ajnr.A5955"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Matsuda Y, Jang DK, Chung J, et al. Preliminary outcomes of single antiplatelet therapy for surface-modified flow diverters in an animal model: analysis of neointimal development and thrombus formation using OCT. <i>J Neurointerv Surg<\/i> 2019; 11: 74\u201379.","DOI":"10.1136\/neurintsurg-2018-013935"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Matsuda Y, Chung J, Lopes DK. Analysis of neointima development in flow diverters using optical coherence tomography imaging. <i>J Neurointerv Surg<\/i> 2018; 10: 162\u2013167.","DOI":"10.1136\/neurintsurg-2016-012969"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Potts MB, Hurley MC, Ansari SA, et al. Mechanical thrombectomy for delayed thrombosis of Pipeline Embolization Device. <i>World Neurosurg<\/i> 2020; 140: 237\u2013240.","DOI":"10.1016\/j.wneu.2020.04.202"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Saatci I, Yavuz K, Ozer C, et al. Treatment of intracranial aneurysms using the Pipeline flow-diverter embolization device: a single-center experience with long-term follow-up results. <i>AJNR Am J Neuroradiol<\/i> 2012; 33: 1436\u20131446.","DOI":"10.3174\/ajnr.A3246"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Chia GS, de Villiers L, Carraro do Nascimento V, et al. Safety and clinical effectiveness of Pipeline Shield device for intracranial aneurysms in an Australian cohort (SCOPE-AUS). <i>Stroke Vasc Interv Neurol<\/i> 2022; 2: e000292.","DOI":"10.1161\/SVIN.121.000292"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Matsubara H, Mizutani D, Egashira Y, et al. Perioperative antiplatelet therapy for the stent-assisted coil embolization: results of the questionnaire survey. <i>J Neuroendovasc Ther<\/i> 2023; 17: 56\u201360.","DOI":"10.5797\/jnet.oa.2022-0053"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Park KY, Ozaki T, Kostynskyy A, et al. Ticagrelor versus clopidogrel in the dual antiplatelet regimen for intracranial stenting or flow-diverter treatment for unruptured cerebral aneurysms: a single-center cohort study. <i>AJNR Am J Neuroradiol<\/i> 2021; 42: 1638\u20131644.","DOI":"10.3174\/ajnr.A7216"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Moore JM, Adeeb N, Shallwani H, et al. A multicenter cohort comparison study of the safety, efficacy, and cost of ticagrelor compared to clopidogrel in aneurysm flow diverter procedures. <i>Neurosurgery<\/i> 2017; 81: 665\u2013671.","DOI":"10.1093\/neuros\/nyx079"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Soize S, Foussier C, Manceau PF, et al. Comparison of two preventive dual antiplatelet regimens for unruptured intracranial aneurysm embolization with flow diverter\/disrupter: a matched-cohort study comparing clopidogrel with ticagrelor. <i>J Neuroradiol<\/i> 2019; 46: 378\u2013383.","DOI":"10.1016\/j.neurad.2019.01.094"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Adeeb N, Griessenauer CJ, Foreman PM, et al. Use of platelet function testing before Pipeline Embolization Device placement: a multicenter cohort study. <i>Stroke<\/i> 2017; 48: 1322\u20131330.","DOI":"10.1161\/STROKEAHA.116.015308"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Fujimoto S, Iguchi Y, Yamagami H, et al. P2Y<sub>12<\/sub> reaction units with prasugrel in acute large artery atherosclerosis and transient ischemic attack: an open-label randomized controlled study, ACUTE-PRAS. <i>Circ J<\/i> 2025; 89: 1922\u20131930.","DOI":"10.1253\/circj.CJ-24-0949"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Mega JL, Close SL, Wiviott SD, et al. Cytochrome P-450 polymorphisms and response to clopidogrel. <i>N Engl J Med<\/i> 2009; 360: 354\u2013362.","DOI":"10.1056\/NEJMoa0809171"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Bauer T, Bouman HJ, van Werkum JW, et al. Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. <i>BMJ<\/i> 2011; 343: d4588.","DOI":"10.1136\/bmj.d4588"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Delgado Almandoz JE, Crandall BM, Scholz JM, et al. 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Flow-diversion effect of LEO stents: aneurysm occlusion and flow remodeling of covered side branches and perforators. <i>AJNR Am J Neuroradiol<\/i> 2018; 39: 2057\u20132063.","DOI":"10.3174\/ajnr.A5803"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Toyoda K, Yasaka M, Iwade K, et al. Dual antithrombotic therapy increases severe bleeding events in patients with stroke and cardiovascular disease: a prospective, multicenter, observational study. <i>Stroke<\/i> 2008; 39: 1740\u20131745.","DOI":"10.1161\/STROKEAHA.107.504993"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Toyoda K, Yasaka M, Uchiyama S, et al. Blood pressure levels and bleeding events during antithrombotic therapy: the Bleeding with Antithrombotic Therapy (BAT) study. <i>Stroke<\/i> 2010; 41: 1440\u20131444.","DOI":"10.1161\/STROKEAHA.110.580506"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Nakagawa I, Park HS, Yokoyama S, et al. 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Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis. <i>Lancet<\/i> 2021; 397: 1470\u20131483.","DOI":"10.1016\/S0140-6736(21)00533-X"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Ozaki T, Yamagami H, Morimoto M, et al. Short- versus long-term Dual AntiPlatelet Therapy for Stent-Assisted treatment of CErebral aneurysm (DAPTS ACE): a multicenter, open-label, randomized clinical trial. <i>J Neurointerv Surg<\/i> 2024; 16: 171\u2013176.","DOI":"10.1136\/jnis-2022-019867"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Watanabe H, Domei T, Morimoto T, et al. 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Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial. <i>Lancet<\/i> 2024; 403: 1866\u20131878.","DOI":"10.1016\/S0140-6736(24)00473-2"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Mohammaden MH, English SW, Stapleton CJ, et al. Safety and efficacy of ticagrelor as single antiplatelet therapy in prevention of thromboembolic complications associated with the Pipeline Embolization Device (PED): multicenter experience. <i>J Neurointerv Surg<\/i> 2020; 12: 1113\u20131116.","DOI":"10.1136\/neurintsurg-2020-015978"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Hellstern V, Aguilar P\u00e9rez M, Henkes E, et al. Use of a p64 MW flow diverter with hydrophilic polymer coating (HPC) and prasugrel single antiplatelet therapy for the treatment of unruptured anterior circulation aneurysms: safety data and short-term occlusion rates. <i>Cardiovasc Intervent Radiol<\/i> 2022; 45: 1364\u20131374.","DOI":"10.1007\/s00270-022-03153-8"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Suyama K, Nakahara I, Matsumoto S, et al. Efficacy and safety of dual antiplatelet therapy with the routine use of prasugrel for flow diversion of cerebral unruptured aneurysms. <i>Clin Neuroradiol<\/i> 2024; 34: 201\u2013208.","DOI":"10.1007\/s00062-023-01355-2"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Goertz L, Hohenstatt S, Vollherbst DF, et al. Safety and efficacy of coated flow diverters in the treatment of cerebral aneurysms during single antiplatelet therapy: a multicenter study. <i>Interv Neuroradiol<\/i> 2024; 30: 819\u2013826.","DOI":"10.1177\/15910199241286542"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Hohenstatt S, Saatci I, Jesser J, et al. Prasugrel single antiplatelet therapy versus aspirin and clopidogrel dual antiplatelet therapy for flow diverter treatment for cerebral aneurysms: a retrospective multicenter study. <i>AJNR Am J Neuroradiol<\/i> 2024; 45: 592\u2013598.","DOI":"10.3174\/ajnr.A8163"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Girdhar G, Andersen A, Pangerl E, et al. Thrombogenicity assessment of Pipeline Flex, Pipeline Shield, and FRED flow diverters in an in vitro human blood physiological flow loop model. <i>J Biomed Mater Res A<\/i> 2018; 106: 3195\u20133202.","DOI":"10.1002\/jbm.a.36514"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Pumar JM, Banguero A, Arias-Rivas S, et al. Rescue treatment in acute thrombosis of intracranial stents. <i>Rev Neurol<\/i> 2014; 58: 113\u2013116. (in Spanish)","DOI":"10.33588\/rn.5803.2013458"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Hohenstatt S, Ulfert C, Herweh C, et al. Acute intraprocedural thrombosis after flow diverter stent implantation: risk factors and relevance of standard observation time for early detection and management. <i>Clin Neuroradiol<\/i> 2023; 33: 343\u2013351.","DOI":"10.1007\/s00062-022-01214-6"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Dornbos D 3rd, Katz JS, Youssef P, et al. Glycoprotein IIb\/IIIa inhibitors in prevention and rescue treatment of thromboembolic complications during endovascular embolization of intracranial aneurysms. <i>Neurosurgery<\/i> 2018; 82: 268\u2013277.","DOI":"10.1093\/neuros\/nyx170"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Hohenstatt S, Vollherbst DF, Nguyen TN, et al. The SAFEST study: survey on antiplatelets in flow diversion for aneurysm endovascular treatment. <i>Stroke Vasc Interv Neurol<\/i> 2024; 4: e001464.","DOI":"10.1161\/SVIN.124.001464"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Ospel JM, Brouwer P, Dorn F, et al. Antiplatelet management for stent-assisted coiling and flow diversion of ruptured intracranial aneurysms: a DELPHI consensus statement. <i>AJNR Am J Neuroradiol<\/i> 2020; 41: 1856\u20131862.","DOI":"10.3174\/ajnr.A6814"}],"container-title":["Journal of Neuroendovascular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnet\/20\/1\/20_ra.2026-0110\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:34:25Z","timestamp":1791002065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnet\/20\/1\/20_ra.2026-0110\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5797\/jnet.ra.2026-0110","relation":{},"ISSN":["1882-4072","2186-2494"],"issn-type":[{"value":"1882-4072","type":"print"},{"value":"2186-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"ra.2026-0110"}}