{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T20:42:38Z","timestamp":1768336958383,"version":"3.49.0"},"reference-count":12,"publisher":"MathDoc\/Centre Mersenne","issue":"S1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    La m\u00e9lio\u00efdose est une maladie infectieuse, tropicale et \u00e9mergente, due \u00e0 une bact\u00e9rie de l\u2019environnement hydrotellurique,\n                    <jats:italic>Burkholderia pseudomallei<\/jats:italic>\n                    , qui est consid\u00e9r\u00e9e comme arme biologique potentielle en raison de ses exceptionnelles capacit\u00e9s de r\u00e9sistance et de virulence. Son extension mondiale, en dehors des foyers end\u00e9miques originels d\u2019Asie du Sud-Est et d\u2019Australie, est favoris\u00e9e par le r\u00e9chauffement climatique et par la pand\u00e9mie de diab\u00e8te de type 2 qui en est le principal facteur pr\u00e9disposant.\n                  <\/jats:p>\n                  <jats:p>\n                    Chez l\u2019Homme, la m\u00e9lio\u00efdose est une infection opportuniste, cons\u00e9cutive \u00e0 une contamination professionnelle (riziculteurs, militaires) ou accidentelle, par inhalation ou par inoculation.\n                    <jats:italic>B.\u00a0pseudomallei<\/jats:italic>\n                    est une bact\u00e9rie intracellulaire facultative qui peut d\u00e9jouer les d\u00e9fenses immunitaires de l\u2019h\u00f4te, induire une infection invasive, aigu\u00eb, subaigu\u00eb ou chronique, ou rester latente pendant des ann\u00e9es. L\u2019infection aigu\u00eb est polymorphe, bact\u00e9ri\u00e9mique dans plus de 50\u00a0% des cas, fr\u00e9quemment compliqu\u00e9e de choc, et r\u00e9v\u00e9l\u00e9e par des abc\u00e8s visc\u00e9raux le plus souvent pulmonaires. Elle est mortelle dans 20 \u00e0 50\u00a0% des cas, le pronostic d\u00e9pendant du d\u00e9lai avant la mise en place d\u2019une antibioth\u00e9rapie efficace, utilisant la ceftazidime ou les carbap\u00e9n\u00e8mes, donc de la rapidit\u00e9 du diagnostic bact\u00e9riologique.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>B.\u00a0pseudomallei<\/jats:italic>\n                    est une bact\u00e9rie saprophyte, r\u00e9sidente de la rhizosph\u00e8re o\u00f9 elle a d\u00e9velopp\u00e9 et accumul\u00e9 des capacit\u00e9s pour supporter les stress environnementaux et la comp\u00e9tition avec les organismes vivant dans cet \u00e9cosyst\u00e8me. Ces m\u00e9canismes d\u2019adaptation sont aussi les facteurs de virulence qui font toute la gravit\u00e9 de la m\u00e9lio\u00efdose, en particulier les pompes d\u2019efflux qui sont le support principal de sa multir\u00e9sistance aux antibiotiques.\n                  <\/jats:p>","DOI":"10.5802\/crbiol.109","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T05:56:56Z","timestamp":1693461416000},"page":"17-21","source":"Crossref","is-referenced-by-count":0,"title":["Une bact\u00e9rie multir\u00e9sistante avant l\u2019\u00e8re des antibiotiques\u00a0: l\u2019agent de la m\u00e9lio\u00efdose"],"prefix":"10.5802","volume":"346","author":[{"given":"Yves","family":"Buisson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3842","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"issue":"1","key":"key2025102316435353384_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2015.8","article-title":"Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis","volume":"1","author":"Limmathurotsakul, D.","year":"2016","unstructured":"[1] Limmathurotsakul, D.; Golding, N.; Dance, D.\u00a0A. et al. 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