{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T20:32:32Z","timestamp":1768336352172,"version":"3.49.0"},"reference-count":10,"publisher":"MathDoc\/Centre Mersenne","issue":"S2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Gillian Butler-Browne began working on muscle at the Institut Pasteur in the laboratory of Fran\u00e7ois Gros in 1978. She characterized the expression profile of different myosin isoforms during both human and rodent development. Vincent Mouly joined this laboratory for his PhD in 1982, and defined the different populations of myoblasts appearing during development in birds and then in humans. Together, they demonstrated the impact of the limit in proliferation of the precursor cells on the regenerative capacity of human skeletal muscle, and their group developed models to evaluate the regenerative potential of skeletal muscle in vitro, measuring the telomeric erosion, and identified the involvement of a stress pathway in the proliferative arrest of muscle progenitors. A platform to produce human immortalized muscle cell lines was the successful result of this research, initiated with Fran\u00e7ois Gros and W. E. Wright. The in vivo regenerative potential of human muscle cells was evaluated by injection into muscles of immunodeficient mice. Their group in collaboration with the clinical team of Professor Jean Lacau St-Guily and Professor Sophie Peri\u00e9 completed a successful autologous myoblast transplantation clinical trial for Oculo-pharyngeal muscular dystrophy. This common scientific career was made possible thanks to the precious and always benevolent support of Fran\u00e7ois Gros.<\/jats:p>","DOI":"10.5802\/crbiol.140","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T12:17:31Z","timestamp":1702988251000},"page":"59-63","source":"Crossref","is-referenced-by-count":0,"title":["Our journey with Fran\u00e7ois Gros"],"prefix":"10.5802","volume":"346","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3431-242X","authenticated-orcid":false,"given":"Gillian","family":"Butler-Browne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-4033","authenticated-orcid":false,"given":"Vincent","family":"Mouly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3842","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"key2025102316440107582_1","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1073\/pnas.73.6.2018","article-title":"Protein synthesis and actin heterogeneity in calf muscle cells in culture","volume":"73","author":"Whalen., R. G.","year":"1976","unstructured":"[1] Whalen., R. G.; Butler-Browne, G. S.; Gros, F. Protein synthesis and actin heterogeneity in calf muscle cells in culture, Proc. Natl. Acad. Sci. USA, Volume 73 (1976), pp. 2018-2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key2025102316440107582_2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0022-2836(78)90049-9","article-title":"Identification of a novel form of myosin light chain present in embryonic muscle tissue and cultured muscle cells","volume":"126","author":"Whalen, R. G.","year":"1978","unstructured":"[2] Whalen, R. G.; Butler-Browne, G. S.; Gros, F. Identification of a novel form of myosin light chain present in embryonic muscle tissue and cultured muscle cells, J. Mol. Biol., Volume 126 (1978), pp. 415-431","journal-title":"J. Mol. Biol."},{"key":"key2025102316440107582_3","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/292805a0","article-title":"Three myosin heavy chain isozymes appear sequentially in rat muscle development","volume":"292","author":"Whalen, R. G.","year":"1981","unstructured":"[3] Whalen, R. G.; Sell, S. M.; Butler-Browne, G. S; Schwartz, K.; Bouveret, P.; Pinset-H\u00e4rstr\u00f6m, I. Three myosin heavy chain isozymes appear sequentially in rat muscle development, Nature, Volume 292 (1981), pp. 805-809","journal-title":"Nature"},{"key":"key2025102316440107582_4","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/299830a0","article-title":"Denervation of newborn rat muscle does not block the appearance of adult fast myosin","volume":"299","author":"Butler-Browne, G. S.","year":"1982","unstructured":"[4] Butler-Browne, G. S.; Bugaisky, L. B.; Cu\u00e9noud, S.; Schwartz, K.; Whalen, R. G. 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Chick and quail limb bud myoblast, isolated at different times during muscle development, express stage-specific phenotypes when differentiated in culture, Cell Differ., Volume 20 (1987), pp. 17-25","journal-title":"Cell Differ."},{"key":"key2025102316440107582_6","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/S0012-1606(89)80015-6","article-title":"Tissue specific transcriptional control of a and b tropomyosins in chicken development","volume":"131","author":"Meinnel, T.","year":"1989","unstructured":"[6] Meinnel, T.; Libri, D.; Mouly, V.; Gros, D.; Fiszman, M. Y.; Lemonnier, M. Tissue specific transcriptional control of a and b tropomyosins in chicken development, Dev. Biol., Volume 131 (1989), pp. 430-438","journal-title":"Dev. 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H\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 myoblastique et filiation myog\u00e9nique, M\u00e9decine\/Sciences, Volume 6 (1990), pp. 245-251","journal-title":"M\u00e9decine\/Sciences"},{"key":"key2025102316440107582_10","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1474-9726.2007.00306.x","article-title":"Cellular senescence in human myoblasts is overcome by hTERT and cdk-4: consequences in ageing muscle and therapeutic strategies for muscular dystrophies","volume":"6","author":"Zhu, C. H.","year":"2007","unstructured":"[10] Zhu, C. H.; Mouly, V.; Cooper, R. N.; Mamchaoui, K.; Bigot, A.; Shay, J.; Di Santo, J.; Butler-Browne, G. S.; Wright, W. E. Cellular senescence in human myoblasts is overcome by hTERT and cdk-4: consequences in ageing muscle and therapeutic strategies for muscular dystrophies, Aging Cell, Volume 6 (2007), pp. 515-523","journal-title":"Aging Cell"}],"container-title":["Comptes Rendus. 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