{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T07:40:08Z","timestamp":1772264408584,"version":"3.50.1"},"reference-count":22,"publisher":"MathDoc\/Centre Mersenne","issue":"S2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>I joined the laboratory of Professor Francois Gros in 1987 and worked there as a postdoc with Robert Whalen until 1992. I recount the research we carried out and mention that of the other scientists also working on skeletal muscle on the 6th floor of the Molecular Biology Department of the Institut Pasteur at that time. I then present my subsequent research when I returned to Japan. I pay tribute to the influence of Professor Gros and to his support in establishing Japanese\/French meetings on muscle biology and muscular dystrophy. I also invoke personal memories of Robert Whalen and Margaret Buckingham and remember the occasions when I returned to Paris to honour Fran\u00e7ois Gros.<\/jats:p>","DOI":"10.5802\/crbiol.141","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T11:53:31Z","timestamp":1702986811000},"page":"45-49","source":"Crossref","is-referenced-by-count":0,"title":["Memories of Professor Fran\u00e7ois Gros"],"prefix":"10.5802","volume":"346","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-6290","authenticated-orcid":false,"given":"Shin\u2019ichi","family":"Takeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3842","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"issue":"4","key":"key2025102316435937990_1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/0092-8674(89)90583-7","article-title":"Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD","volume":"56","author":"Wright, W.\u00a0E.","year":"1989","unstructured":"[1] Wright, W.\u00a0E.; Sassoon, D.\u00a0A.; Lin, V.\u00a0K. Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD, Cell, Volume 56 (1989) no. 4, pp. 607-617","journal-title":"Cell"},{"issue":"6240","key":"key2025102316435937990_2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/341303a0","article-title":"Expression of two myogenic regulatory factors\u00a0myogenin\u00a0and MyoD1 during mouse embryogenesis","volume":"341","author":"Sassoon, D.","year":"1989","unstructured":"[2] Sassoon, D.; Lyons, G.; Wright, W.\u00a0E.; Lin, V.; Lassar, A.; Weintraub, H.; Buckingham, M. Expression of two myogenic regulatory factors\u00a0myogenin\u00a0and MyoD1 during mouse embryogenesis, Nature, Volume 341 (1989) no. 6240, pp. 303-307","journal-title":"Nature"},{"issue":"6606","key":"key2025102316435937990_3","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/384266a0","article-title":"Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice","volume":"384","author":"Tajbakhsh, S.","year":"1996","unstructured":"[3] Tajbakhsh, S.; Rocancourt, D.; Buckingham, M. Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice, Nature, Volume 384 (1996) no. 6606, pp. 266-270","journal-title":"Nature"},{"issue":"10","key":"key2025102316435937990_4","doi-asserted-by":"publisher","first-page":"5197","DOI":"10.1073\/pnas.76.10.5197","article-title":"Contractile protein isozymes in muscle development: identification of an embryonic form of myosin heavy chain.","volume":"76","author":"Whalen, R.\u00a0G.","year":"1979","unstructured":"[4] Whalen, R.\u00a0G.; Schwartz, K.; Bouveret, P.; Sell, S.\u00a0M.; Gros, F. Contractile protein isozymes in muscle development: identification of an embryonic form of myosin heavy chain., Proc. Natl. Acad. Sci. USA, Volume 76 (1979) no. 10, pp. 5197-5201","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5774","key":"key2025102316435937990_5","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/286731a0","article-title":"Myosin from fetal hearts contains the skeletal muscle embryonic light chain","volume":"286","author":"Whalen, R.\u00a0G.","year":"1980","unstructured":"[5] Whalen, R.\u00a0G.; Sell, S.\u00a0M. Myosin from fetal hearts contains the skeletal muscle embryonic light chain, Nature, Volume 286 (1980) no. 5774, pp. 731-733","journal-title":"Nature"},{"issue":"5826","key":"key2025102316435937990_6","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/292805a0","article-title":"Three myosin heavy-chain isozymes appear sequentially in rat muscle development","volume":"292","author":"Whalen, R.\u00a0G.","year":"1981","unstructured":"[6] Whalen, R.\u00a0G.; Sell, S.\u00a0M.; Butler-Browne, G.\u00a0S.; Schwartz, K.; Bouveret, P.; Pinset-H\u00e4rst\u00f6m, I. Three myosin heavy-chain isozymes appear sequentially in rat muscle development, Nature, Volume 292 (1981) no. 5826, pp. 805-809","journal-title":"Nature"},{"issue":"5886","key":"key2025102316435937990_7","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/299830a0","article-title":"Denervation of newborn rat muscle does not block the appearance of adult fast myosin heavy chain","volume":"299","author":"Butler-Browne, G.\u00a0S.","year":"1982","unstructured":"[7] Butler-Browne, G.\u00a0S.; Bugaisky, L.\u00a0B.; Cu\u00e9noud, S.; Schwartz, K.; Whalen, R.\u00a0G. Denervation of newborn rat muscle does not block the appearance of adult fast myosin heavy chain, Nature, Volume 299 (1982) no. 5886, pp. 830-833","journal-title":"Nature"},{"issue":"12","key":"key2025102316435937990_8","first-page":"467","article-title":"Evolutionarily conserved promoter motifs and enhancer organization in the mouse gene encoding the IIB myosin heavy chain isoform expressed in adult fast skeletal muscle","volume":"315","author":"Takeda, S.","year":"1992","unstructured":"[8] Takeda, S.; North, D.\u00a0L.; Lakich, M.\u00a0M.; Russell, S.\u00a0D.; Kahng, L.\u00a0S.; Whalen, R.\u00a0G. Evolutionarily conserved promoter motifs and enhancer organization in the mouse gene encoding the IIB myosin heavy chain isoform expressed in adult fast skeletal muscle, C.R. Acad. Sci. III, Volume 315 (1992) no. 12, pp. 467-472","journal-title":"C.R. Acad. Sci. 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Chem."},{"issue":"26","key":"key2025102316435937990_10","doi-asserted-by":"publisher","first-page":"15664","DOI":"10.1074\/jbc.270.26.15664","article-title":"Myogenic regulatory factors can activate TATA-containing promoter elements via an E-box independent mechanism","volume":"270","author":"Takeda, S.","year":"1995","unstructured":"[10] Takeda, S.; North, D.\u00a0L.; Diagana, T.; Miyagoe, Y.; Lakich, M.\u00a0M.; Whalen, R.\u00a0G. Myogenic regulatory factors can activate TATA-containing promoter elements via an E-box independent mechanism, J. Biol. Chem., Volume 270 (1995) no. 26, pp. 15664-15670","journal-title":"J. Biol. 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Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination, Cell Rep., Volume 42 (2023) no. 4, 112289","journal-title":"Cell Rep."},{"issue":"12","key":"key2025102316435937990_12","doi-asserted-by":"publisher","first-page":"5307","DOI":"10.1073\/pnas.92.12.5307","article-title":"DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans.","volume":"92","author":"Michel, M.\u00a0L.","year":"1995","unstructured":"[12] Michel, M.\u00a0L.; Davis, H.\u00a0L.; Schleef, M.; Mancini, M.; Tiollais, P.; Whalen, R.\u00a0G. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans., Proc. Natl. Acad. Sci. USA, Volume 92 (1995) no. 12, pp. 5307-5311","journal-title":"Proc. Natl. Acad. Sci. 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Neurol."},{"issue":"437","key":"key2025102316435937990_14","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan0713","article-title":"Systemic administration of the antisense oligonucleotide NS-065\/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy.","volume":"10","author":"Komaki, H.","year":"2018","unstructured":"[14] Komaki, H.; Nagata, T.; Saito, T.; Masuda, S.; Takeshita, E.; Sasaki, M.; Tachimori, H.; Nakamura, H.; Aoki, Y.; Takeda, S. Systemic administration of the antisense oligonucleotide NS-065\/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy., Sci. Transl. Med., Volume 10 (2018) no. 437, eaan0713","journal-title":"Sci. Transl. 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Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy, FEBS Lett., Volume 415 (1997) no. 1, pp. 33-39","journal-title":"FEBS Lett."},{"issue":"4","key":"key2025102316435937990_16","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1074\/jbc.274.4.2193","article-title":"alpha1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degeneration","volume":"274","author":"Kameya, S.","year":"1999","unstructured":"[16] Kameya, S.; Miyagoe, Y.; Nonaka, I.; Ikemoto, T.; Endo, M.; Hanaoka, K.; Nabeshima, Y.; Takeda, S. alpha1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degeneration, J. Biol. Chem., Volume 274 (1999) no. 4, pp. 2193-2200","journal-title":"J. Biol. 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Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71, Circulation, Volume 117 (2008) no. 19, pp. 2437-2448","journal-title":"Circulation"},{"issue":"10","key":"key2025102316435937990_18","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1634\/stemcells.2007-0019","article-title":"Molecular signature of quiescent satellite cells in adult skeletal muscle","volume":"25","author":"Fukada, S.","year":"2007","unstructured":"[18] Fukada, S.; Uezumi, A.; Ikemoto, M.; Masuda, S.; Segawa, M.; Tanimura, N.; Yamamoto, H.; Miyagoe-Suzuki, Y.; Takeda, S. 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Cell Biol."},{"issue":"9","key":"key2025102316435937990_20","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1172\/JCI30654","article-title":"NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS","volume":"117","author":"Suzuki, N.","year":"2007","unstructured":"[20] Suzuki, N.; Motohashi, N.; Uezumi, A.; Fukada, S.; Yoshimura, T.; Itoyama, Y.; Aoki, M.; Miyagoe-Suzuki, Y.; Takeda, S. NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS, J. Clin. Invest., Volume 117 (2007) no. 9, pp. 2468-2476","journal-title":"J. Clin. Invest."},{"issue":"1","key":"key2025102316435937990_21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nm.3019","article-title":"Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy","volume":"19","author":"Ito, N.","year":"2013","unstructured":"[21] Ito, N.; Ruegg, U.\u00a0T.; Kudo, A.; Miyagoe-Suzuki, Y.; Takeda, S. Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy, Nat. Med., Volume 19 (2013) no. 1, pp. 101-106","journal-title":"Nat. Med."},{"issue":"11","key":"key2025102316435937990_22","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1093\/hmg\/ddab100","article-title":"Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice","volume":"30","author":"Nogami, K.","year":"2021","unstructured":"[22] Nogami, K.; Maruyama, Y.; Sakai-Takemura, F.; Motohashi, N.; Elhussieny, A.; Imamura, M.; Miyashita, S.; Ogawa, M.; Noguchi, S.; Tamura, Y.; Kira, J.\u00a0I.; Aoki, Y.; Takeda, S.; Miyagoe-Suzuki, Y. Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice, Hum. Mol. Genet., Volume 30 (2021) no. 11, pp. 1006-1019","journal-title":"Hum. Mol. Genet."}],"container-title":["Comptes Rendus. 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