{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:48:13Z","timestamp":1792280893198,"version":"4.4.0"},"reference-count":83,"publisher":"MathDoc\/Centre Mersenne","issue":"G1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Congenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract development with neural crest cells. Genetic or environmental perturbation of SHF deployment thus underlies a spectrum of common forms of CHD affecting conotruncal and septal morphogenesis. Here we review the major properties of SHF cells as well as recent insights into the developmental programs that drive normal cardiac progenitor cell addition and the origins of CHD.<\/jats:p>","DOI":"10.5802\/crbiol.151","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T10:46:15Z","timestamp":1710499575000},"page":"9-18","source":"Crossref","is-referenced-by-count":11,"title":["On the involvement of the second heart field in congenital heart defects"],"prefix":"10.5802","volume":"347","author":[{"given":"Clara","family":"Guijarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-0073","authenticated-orcid":false,"given":"Robert G.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"key2025102316440588692_1","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/nature06801","article-title":"The developmental genetics of congenital heart disease","volume":"451","author":"Bruneau, B. G.","year":"2008","unstructured":"[1] Bruneau, B. G. The developmental genetics of congenital heart disease, Nature, Volume 451 (2008), pp. 943-948","journal-title":"Nature"},{"key":"key2025102316440588692_2","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1056\/NEJMra1003941","article-title":"Epstein lecture. Cardiac development and implications for heart disease","volume":"363","author":"Epstein, J. A.","year":"2010","unstructured":"[2] Epstein, J. A.; Franklin, H. Epstein lecture. Cardiac development and implications for heart disease, New Engl. J. Med., Volume 363 (2010), pp. 1638-1647","journal-title":"New Engl. J. Med."},{"key":"key2025102316440588692_3","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015750","article-title":"Heart fields and cardiac morphogenesis","volume":"4","author":"Kelly, R. G.","year":"2014","unstructured":"[3] Kelly, R. G.; Buckingham, M. E.; Moorman, A. F. Heart fields and cardiac morphogenesis, Cold Spring Harb. Perspect. Med., Volume 4 (2014), a015750","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"key2025102316440588692_4","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03848","article-title":"Early patterning and specification of cardiac progenitors in gastrulating mesoderm","volume":"3","author":"Devine, W. P.","year":"2014","unstructured":"[4] Devine, W. P.; Wythe, J. D.; George, M.; Koshiba-Takeuchi, K.; Bruneau, B. G. Early patterning and specification of cardiac progenitors in gastrulating mesoderm, Elife, Volume 3 (2014), e03848","journal-title":"Elife"},{"key":"key2025102316440588692_5","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/ncb3024","article-title":"Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development","volume":"16","author":"Lescroart, F.","year":"2014","unstructured":"[5] Lescroart, F.; Chabab, S.; Lin, X.; Rulands, S.; Paulissen, C.; Rodolosse, A.; Auer, H.; Achouri, Y.; Dubois, C.; Bondue, A.; Simons, B. D.; Blanpain, C. Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development, Nat. Cell Biol., Volume 16 (2014), pp. 829-840","journal-title":"Nat. Cell Biol."},{"key":"key2025102316440588692_6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001200","article-title":"Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak","volume":"19","author":"Ivanovitch, K.","year":"2021","unstructured":"[6] Ivanovitch, K.; Soro-Barrio, P.; Chakravarty, P.; Jones, R. A.; Bell, D. M.; Mousavy Gharavy, S. N.; Stamataki, D.; Delile, J.; Smith, J. C.; Briscoe, J. Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak, PLoS Biol., Volume 19 (2021), e3001200","journal-title":"PLoS Biol."},{"key":"key2025102316440588692_7","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S1534-5807(01)00040-5","article-title":"The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm","volume":"1","author":"Kelly, R. G.","year":"2001","unstructured":"[7] Kelly, R. G.; Brown, N. A.; Buckingham, M. E. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm, Dev. Cell, Volume 1 (2001), pp. 435-440","journal-title":"Dev. Cell"},{"key":"key2025102316440588692_8","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.1242\/dev.128.16.3179","article-title":"Conotruncal myocardium arises from a secondary heart field","volume":"128","author":"Waldo, K. L.","year":"2001","unstructured":"[8] Waldo, K. L.; Kumiski, D. H.; Wallis, K. T.; Stadt, H. A.; Hutson, M. R.; Platt, D. H.; Kirby, M. L. Conotruncal myocardium arises from a secondary heart field, Development, Volume 128 (2001), pp. 3179-3188","journal-title":"Development"},{"key":"key2025102316440588692_9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/dbio.2001.0409","article-title":"The outflow tract of the heart is recruited from a novel heart-forming field","volume":"238","author":"Mjaatvedt, C. H.","year":"2001","unstructured":"[9] Mjaatvedt, C. H.; Nakaoka, T.; Moreno-Rodriguez, R.; Norris, R. A.; Kern, M. J.; Eisenberg, C. A.; Turner, D.; Markwald, R. R. The outflow tract of the heart is recruited from a novel heart-forming field, Dev. Biol., Volume 238 (2001), pp. 97-109","journal-title":"Dev. Biol."},{"key":"key2025102316440588692_10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0022-5320(73)80002-4","article-title":"Origin and differentiation of cardiac muscle cells in the mouse","volume":"42","author":"Viragh, S.","year":"1973","unstructured":"[10] Viragh, S.; Challice, C. E. Origin and differentiation of cardiac muscle cells in the mouse, J.\u00a0Ultrastruct. Res., Volume 42 (1973), pp. 1-24","journal-title":"J.\u00a0Ultrastruct. Res."},{"key":"key2025102316440588692_11","first-page":"661","article-title":"Experimental study of the development of the truncus and the conus in the chick embryo","volume":"123","author":"de la Cruz, M. V.","year":"1977","unstructured":"[11] de la Cruz, M. V.; Sanchez Gomez, C.; Arteaga, M. M.; Arguello, C. Experimental study of the development of the truncus and the conus in the chick embryo, J.\u00a0Anat., Volume 123 (1977), pp. 661-686","journal-title":"J.\u00a0Anat."},{"key":"key2025102316440588692_12","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S1534-5807(04)00133-9","article-title":"The clonal origin of myocardial cells in different regions of the embryonic mouse heart","volume":"6","author":"Meilhac, S. M.","year":"2004","unstructured":"[12] Meilhac, S. M.; Esner, M.; Kelly, R. G.; Nicolas, J. F.; Buckingham, M. E. The clonal origin of myocardial cells in different regions of the embryonic mouse heart, Dev. Cell, Volume 6 (2004), pp. 685-698","journal-title":"Dev. Cell"},{"key":"key2025102316440588692_13","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1161\/CIRCRESAHA.112.271064","article-title":"Lineage tree for the venous pole of the heart: clonal analysis clarifies controversial genealogy based on genetic tracing","volume":"111","author":"Lescroart, F.","year":"2012","unstructured":"[13] Lescroart, F.; Mohun, T.; Meilhac, S. M.; Bennett, M.; Buckingham, M. Lineage tree for the venous pole of the heart: clonal analysis clarifies controversial genealogy based on genetic tracing, Circ. Res., Volume 111 (2012), pp. 1313-1322","journal-title":"Circ. Res."},{"key":"key2025102316440588692_14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/B978-0-12-387786-4.00002-6","article-title":"The second heart field","volume":"100","author":"Kelly, R. G.","year":"2012","unstructured":"[14] Kelly, R. G. The second heart field, Curr. Top. Dev. Biol., Volume 100 (2012), pp. 33-65","journal-title":"Curr. Top. Dev. Biol."},{"key":"key2025102316440588692_15","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/S1534-5807(03)00363-0","article-title":"Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart","volume":"5","author":"Cai, C. L.","year":"2003","unstructured":"[15] Cai, C. L.; Liang, X.; Shi, Y.; Chu, P. H.; Pfaff, S.L.; Chen, J.; Evans, S. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart, Dev. Cell, Volume 5 (2003), pp. 877-889","journal-title":"Dev. Cell"},{"key":"key2025102316440588692_16","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ydbio.2005.08.041","article-title":"The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary\/anterior heart field","volume":"287","author":"Verzi, M. P.","year":"2005","unstructured":"[16] Verzi, M. P.; McCulley, D. J.; De Val, S.; Dodou, E.; Black, B. L. The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary\/anterior heart field, Dev. Biol., Volume 287 (2005), pp. 134-145","journal-title":"Dev. Biol."},{"key":"key2025102316440588692_17","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1242\/dev.02365","article-title":"Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract","volume":"133","author":"Tirosh-Finkel, L.","year":"2006","unstructured":"[17] Tirosh-Finkel, L.; Elhanany, H.; Rinon, A.; Tzahor, E. Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract, Development, Volume 133 (2006), pp. 1943-1953","journal-title":"Development"},{"key":"key2025102316440588692_18","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.celrep.2017.01.002","article-title":"Temporally distinct Six2-positive second heart field progenitors regulate mammalian heart development and disease","volume":"18","author":"Zhou, Z.","year":"2017","unstructured":"[18] Zhou, Z.; Wang, J.; Guo, C.; Chang, W.; Zhuang, J.; Zhu, P.; Li, X. Temporally distinct Six2-positive second heart field progenitors regulate mammalian heart development and disease, Cell Rep., Volume 18 (2017), pp. 1019-1032","journal-title":"Cell Rep."},{"key":"key2025102316440588692_19","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1242\/dev.050674","article-title":"Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo","volume":"137","author":"Lescroart, F.","year":"2010","unstructured":"[19] Lescroart, F.; Kelly, R. G.; Le Garrec, J. F.; Nicolas, J. F.; Meilhac, S. M.; Buckingham, M. Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo, Development, Volume 137 (2010), pp. 3269-3279","journal-title":"Development"},{"key":"key2025102316440588692_20","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1073\/pnas.1424538112","article-title":"Clonal analysis reveals a common origin between nonsomite-derived neck muscles and heart myocardium","volume":"112","author":"Lescroart, F.","year":"2015","unstructured":"[20] Lescroart, F.; Hamou, W.; Francou, A.; Theveniau-Ruissy, M.; Kelly, R. G.; Buckingham, M. Clonal analysis reveals a common origin between nonsomite-derived neck muscles and heart myocardium, Proc. Natl. Acad. Sci. USA, Volume 112 (2015), pp. 1446-1451","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key2025102316440588692_21","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature14435","article-title":"A new heart for a new head in vertebrate cardiopharyngeal evolution","volume":"520","author":"Diogo, R.","year":"2015","unstructured":"[21] Diogo, R.; Kelly, R. G.; Christiaen, L.; Levine, M.; Ziermann, J. M.; Molnar, J. L.; Noden, D. M.; Tzahor, E. A new heart for a new head in vertebrate cardiopharyngeal evolution, Nature, Volume 520 (2015), pp. 466-473","journal-title":"Nature"},{"key":"key2025102316440588692_22","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112931","article-title":"Emergence of heart and branchiomeric muscles in cardiopharyngeal mesoderm","volume":"410","author":"Lescroart, F.","year":"2022","unstructured":"[22] Lescroart, F.; Dumas, C. E.; Adachi, N.; Kelly, R. G. Emergence of heart and branchiomeric muscles in cardiopharyngeal mesoderm, Exp. Cell Res., Volume 410 (2022), 112931","journal-title":"Exp. Cell Res."},{"key":"key2025102316440588692_23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26966-6","article-title":"Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm","volume":"12","author":"Nomaru, H.","year":"2021","unstructured":"[23] Nomaru, H.; Liu, Y.; De Bono, C.; Righelli, D.; Cirino, A.; Wang, W.; Song, H.; Racedo, S. E.; Dantas, A. G.; Zhang, L.; Cai, C. L.; Angelini, C.; Christiaen, L.; Kelly, R. G.; Baldini, A.; Zheng, D.; Morrow, B. E. Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm, Nat. Commun., Volume 12 (2021), 6645","journal-title":"Nat. Commun."},{"key":"key2025102316440588692_24","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1101\/gr.190595.115","article-title":"Defining cell types and states with single-cell genomics","volume":"25","author":"Trapnell, C.","year":"2015","unstructured":"[24] Trapnell, C. Defining cell types and states with single-cell genomics, Genome Res., Volume 25 (2015), pp. 1491-1498","journal-title":"Genome Res."},{"key":"key2025102316440588692_25","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2986","article-title":"Characterization of a common progenitor pool of the epicardium and myocardium","volume":"371","author":"Tyser, R. C. V.","year":"2021","unstructured":"[25] Tyser, R. C. V.; Ibarra-Soria, X.; McDole, K.; Arcot Jayaram, S.; Godwin, J.; van den Brand, T. A. H.; Miranda, A. M. A.; Scialdone, A.; Keller, P. J.; Marioni, J. C.; Srinivas, S. Characterization of a common progenitor pool of the epicardium and myocardium, Science, Volume 371 (2021), eabb2986","journal-title":"Science"},{"key":"key2025102316440588692_26","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1161\/CIRCRESAHA.121.318943","article-title":"Unveiling complexity and multipotentiality of early heart fields","volume":"129","author":"Zhang, Q.","year":"2021","unstructured":"[26] Zhang, Q.; Carlin, D.; Zhu, F.; Cattaneo, P.; Ideker, T.; Evans, S. M.; Bloomekatz, J.; Chi, N. C. Unveiling complexity and multipotentiality of early heart fields, Circ. Res., Volume 129 (2021), pp. 474-487","journal-title":"Circ. Res."},{"key":"key2025102316440588692_27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.devcel.2023.01.010","article-title":"The heart field transcriptional landscape at single-cell resolution","volume":"58","author":"Kelly, R. G.","year":"2023","unstructured":"[27] Kelly, R. G. The heart field transcriptional landscape at single-cell resolution, Dev. Cell, Volume 58 (2023), pp. 257-266","journal-title":"Dev. Cell"},{"key":"key2025102316440588692_28","doi-asserted-by":"publisher","DOI":"10.1101\/2022.12.26.521947","article-title":"Moelcular characterization of left-right symmetry breaking in the mouse embryo","author":"Tyser, R. C. V.","year":"2022","unstructured":"[28] Tyser, R. C. V.; Ibarra-Soria, X.; Pedroza, M.; Miranda, A. M. A.; van den Brand, T. A. H.; Scialdone, A.; Marioni, J. C.; Srinivas, S. Moelcular characterization of left-right symmetry breaking in the mouse embryo, 2022 (bioRxiv)"},{"key":"key2025102316440588692_29","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.devcel.2020.10.008","article-title":"Transient nodal signaling in left precursors coordinates opposed asymmetries shaping the heart loop","volume":"55","author":"Desgrange, A.","year":"2020","unstructured":"[29] Desgrange, A.; Le Garrec, J. F.; Bernheim, S.; Bonnelykke, T. H.; Meilhac, S. M. Transient nodal signaling in left precursors coordinates opposed asymmetries shaping the heart loop, Dev. Cell, Volume 55 (2020), pp. 413-431","journal-title":"Dev. Cell"},{"key":"key2025102316440588692_30","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.semcdb.2020.04.017","article-title":"Role of cilia in the pathogenesis of congenital heart disease","volume":"110","author":"Gabriel, G. C.","year":"2021","unstructured":"[30] Gabriel, G. C.; Young, C. B.; Lo, C. W. Role of cilia in the pathogenesis of congenital heart disease, Semin. Cell Dev. Biol., Volume 110 (2021), pp. 2-10","journal-title":"Semin. Cell Dev. Biol."},{"key":"key2025102316440588692_31","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.cell.2023.01.001","article-title":"Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart","volume":"186","author":"Dominguez, M. H.","year":"2023","unstructured":"[31] Dominguez, M. H.; Leigh Krup, A.; Munice, J. M.; Bruneau, B. G. Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart, Cell, Volume 186 (2023), pp. 479-496","journal-title":"Cell"},{"key":"key2025102316440588692_32","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/s44161-022-00065-1","article-title":"Pseudodynamic analysis of heart tube formation in the mouse reveals strong regional variability and early left\u2013right asymmetry","volume":"1","author":"Esteban, I.","year":"2022","unstructured":"[32] Esteban, I.; Schmidt, P.; Desgrange, A.; Raoila, M.; Temino, S.; Meilhac, S. M.; Kobbelt, L.; Torres, M. Pseudodynamic analysis of heart tube formation in the mouse reveals strong regional variability and early left\u2013right asymmetry, Nat. Cardiovasc. Res., Volume 1 (2022), pp. 504-517","journal-title":"Nat. Cardiovasc. Res."},{"key":"key2025102316440588692_33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004871","article-title":"Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development","volume":"10","author":"Ramsbottom, S. A.","year":"2014","unstructured":"[33] Ramsbottom, S. A.; Sharma, V.; Rhee, H. J.; Eley, L.; Phillips, H. M.; Rigby, H. F.; Dean, C.; Chaudhry, B.; Henderson, D. J. Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development, PLoS Genet., Volume 10 (2014), e1004871","journal-title":"PLoS Genet."},{"key":"key2025102316440588692_34","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa6071","article-title":"HEART development. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts","volume":"348","author":"Jain, R.","year":"2015","unstructured":"[34] Jain, R.; Li, D.; Gupta, M.; Manderfield, L. J.; Ifkovits, J. L.; Wang, Q.; Liu, F.; Liu, Y.; Poleshko, A.; Padmanabhan, A.; Raum, J. C.; Li, L.; Morrisey, E. E.; Lu, M. M.; Won, K. J.; Epstein, J. A. HEART development. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts, Science, Volume 348 (2015), aaa6071","journal-title":"Science"},{"key":"key2025102316440588692_35","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019334","article-title":"Is transposition of the great arteries associated with shortening of the intrapericardial portions of the great arterial trunks? An echocardiographic analysis on newborn infants with simple transposition of the great arteries to explore an animal model-based hypothesis on human beings","volume":"10","author":"Omer, S. O.","year":"2021","unstructured":"[35] Omer, S. O.; Alhabshan, F. M.; Jijeh, A. M. Z.; Caimbon, N. C.; Enriquez, C. C.; Manner, J.; Yelbuz, T. M. Is transposition of the great arteries associated with shortening of the intrapericardial portions of the great arterial trunks? An echocardiographic analysis on newborn infants with simple transposition of the great arteries to explore an animal model-based hypothesis on human beings, J.\u00a0Am. Heart Assoc., Volume 10 (2021), e019334","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"key2025102316440588692_36","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1161\/CIRCRESAHA.109.194464","article-title":"Signaling pathways controlling second heart field development","volume":"104","author":"Rochais, F.","year":"2009","unstructured":"[36] Rochais, F.; Mesbah, K.; Kelly, R. G. Signaling pathways controlling second heart field development, Circ. Res., Volume 104 (2009), pp. 933-942","journal-title":"Circ. Res."},{"key":"key2025102316440588692_37","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ydbio.2009.10.009","article-title":"The role of secondary heart field in cardiac development","volume":"336","author":"Dyer, L. A.","year":"2009","unstructured":"[37] Dyer, L. A.; Kirby, M. L. The role of secondary heart field in cardiac development, Dev. Biol., Volume 336 (2009), pp. 137-144","journal-title":"Dev. Biol."},{"key":"key2025102316440588692_38","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1161\/CIRCRESAHA.117.310838","article-title":"Epithelial properties of the second heart field","volume":"122","author":"Cortes, C.","year":"2018","unstructured":"[38] Cortes, C.; Francou, A.; De Bono, C.; Kelly, R. G. Epithelial properties of the second heart field, Circ. Res., Volume 122 (2018), pp. 142-154","journal-title":"Circ. Res."},{"key":"key2025102316440588692_39","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.semcdb.2021.06.002","article-title":"Control of cardiomyocyte differentiation timing by intercellular signaling pathways","volume":"118","author":"Rowton, M.","year":"2021","unstructured":"[39] Rowton, M.; Guzzetta, A.; Rydeen, A. B.; Moskowitz, I. P. Control of cardiomyocyte differentiation timing by intercellular signaling pathways, Semin. Cell Dev. Biol., Volume 118 (2021), pp. 94-106","journal-title":"Semin. Cell Dev. Biol."},{"key":"key2025102316440588692_40","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/bs.ctdb.2016.08.002","article-title":"Tbx1: transcriptional and developmental functions","volume":"122","author":"Baldini, A.","year":"2017","unstructured":"[40] Baldini, A.; Fulcoli, F. G.; Illingworth, E. Tbx1: transcriptional and developmental functions, Curr. Top. Dev. Biol., Volume 122 (2017), pp. 223-243","journal-title":"Curr. Top. Dev. Biol."},{"key":"key2025102316440588692_41","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1161\/CIRCRESAHA.109.201665","article-title":"Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries","volume":"106","author":"Watanabe, Y.","year":"2010","unstructured":"[41] Watanabe, Y.; Miyagawa-Tomita, S.; Vincent, S. D.; Kelly, R. G.; Moon, A. M.; Buckingham, M. E. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries, Circ. Res., Volume 106 (2010), pp. 495-503","journal-title":"Circ. Res."},{"key":"key2025102316440588692_42","doi-asserted-by":"publisher","first-page":"18273","DOI":"10.1073\/pnas.1215360109","article-title":"Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium","volume":"109","author":"Watanabe, Y.","year":"2012","unstructured":"[42] Watanabe, Y.; Zaffran, S.; Kuroiwa, A.; Higuchi, H.; Ogura, T.; Harvey, R. P.; Kelly, R. G.; Buckingham, M. Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium, Proc. Natl. Acad. Sci. USA, Volume 109 (2012), pp. 18273-18280","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key2025102316440588692_43","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1242\/dev.115022","article-title":"TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field","volume":"141","author":"Francou, A.","year":"2014","unstructured":"[43] Francou, A.; Saint-Michel, E.; Mesbah, K.; Kelly, R. G. TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field, Development, Volume 141 (2014), pp. 4320-4331","journal-title":"Development"},{"key":"key2025102316440588692_44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002571","article-title":"Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a","volume":"8","author":"Chen, L.","year":"2012","unstructured":"[44] Chen, L.; Fulcoli, F. G.; Ferrentino, R.; Martucciello, S.; Illingworth, E. A.; Baldini, A. Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a, PLoS Genet., Volume 8 (2012), e1002571","journal-title":"PLoS Genet."},{"key":"key2025102316440588692_45","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ydbio.2016.02.017","article-title":"Spatial regulation of cell cohesion by Wnt5a during second heart field progenitor deployment","volume":"412","author":"Li, D.","year":"2016","unstructured":"[45] Li, D.; Sinha, T.; Ajima, R.; Seo, H. S.; Yamaguchi, T. P.; Wang, J. Spatial regulation of cell cohesion by Wnt5a during second heart field progenitor deployment, Dev. Biol., Volume 412 (2016), pp. 18-31","journal-title":"Dev. Biol."},{"key":"key2025102316440588692_46","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14770","article-title":"Epithelial tension in the second heart field promotes mouse heart tube elongation","volume":"8","author":"Francou, A.","year":"2017","unstructured":"[46] Francou, A.; De Bono, C.; Kelly, R. G. Epithelial tension in the second heart field promotes mouse heart tube elongation, Nat. Commun., Volume 8 (2017), 14770","journal-title":"Nat. Commun."},{"key":"key2025102316440588692_47","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1161\/01.CIR.82.2.332","article-title":"Role of neural crest in congenital heart disease","volume":"82","author":"Kirby, M. L.","year":"1990","unstructured":"[47] Kirby, M. L.; Waldo, K. L. Role of neural crest in congenital heart disease, Circulation, Volume 82 (1990), pp. 332-340","journal-title":"Circulation"},{"key":"key2025102316440588692_48","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1161\/01.CIR.0000023044.44974.8A","article-title":"Shortened outflow tract leads to altered cardiac looping after neural crest ablation","volume":"106","author":"Yelbuz, T. M.","year":"2002","unstructured":"[48] Yelbuz, T. M.; Waldo, K. L.; Kumiski, D. H.; Stadt, H. A.; Wolfe, R. R.; Leatherbury, L.; Kirby, M. L. Shortened outflow tract leads to altered cardiac looping after neural crest ablation, Circulation, Volume 106 (2002), pp. 504-510","journal-title":"Circulation"},{"key":"key2025102316440588692_49","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/dvdy.10364","article-title":"Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract","volume":"228","author":"Yelbuz, T. M.","year":"2003","unstructured":"[49] Yelbuz, T. M.; Waldo, K. L.; Zhang, X.; Zdanowicz, M.; Parker, J.; Creazzo, T. L.; Johnson, G. A.; Kirby, M. L. Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract, Dev. Dyn., Volume 228 (2003), pp. 152-160","journal-title":"Dev. Dyn."},{"key":"key2025102316440588692_50","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.amjcard.2010.01.333","article-title":"Cardiovascular anomalies associated with chromosome 22q11.2 deletion syndrome","volume":"105","author":"Momma, K.","year":"2010","unstructured":"[50] Momma, K. Cardiovascular anomalies associated with chromosome 22q11.2 deletion syndrome, Am. J. Cardiol., Volume 105 (2010), pp. 1617-1624","journal-title":"Am. J. Cardiol."},{"key":"key2025102316440588692_51","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1002\/ajmg.a.38662","article-title":"Congenital heart diseases and cardiovascular abnormalities in 22q11.2 deletion syndrome: from well-established knowledge to new frontiers","volume":"176","author":"Unolt, M.","year":"2018","unstructured":"[51] Unolt, M.; Versacci, P.; Anaclerio, S.; Lambiase, C.; Calcagni, G.; Trezzi, M.; Carotti, A.; Crowley, T. B.; Zackai, E. H.; Goldmuntz, E.; Gaynor, J. W.; Digilio, M. C.; McDonald-McGinn, D. M.; Marino, B. Congenital heart diseases and cardiovascular abnormalities in 22q11.2 deletion syndrome: from well-established knowledge to new frontiers, Am. J. Med. Genet. A, Volume 176 (2018), pp. 2087-2098","journal-title":"Am. J. Med. Genet. A"},{"key":"key2025102316440588692_52","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1161\/CIRCRESAHA.108.172189","article-title":"The del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterning","volume":"103","author":"Theveniau-Ruissy, M.","year":"2008","unstructured":"[52] Theveniau-Ruissy, M.; Dandonneau, M.; Mesbah, K.; Ghez, O.; Mattei, M. G.; Miquerol, L.; Kelly, R. G. The del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterning, Circ. Res., Volume 103 (2008), pp. 142-148","journal-title":"Circ. Res."},{"key":"key2025102316440588692_53","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1161\/CIRCRESAHA.115.305020","article-title":"Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart","volume":"115","author":"Rana, M. S.","year":"2014","unstructured":"[53] Rana, M. S.; Theveniau-Ruissy, M.; De Bono, C.; Mesbah, K.; Francou, A.; Rammah, M.; Dominguez, J. N.; Roux, M.; Laforest, B.; Anderson, R. H.; Mohun, T.; Zaffran, S.; Christoffels, V. M.; Kelly, R. G. Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart, Circ. Res., Volume 115 (2014), pp. 790-799","journal-title":"Circ. Res."},{"key":"key2025102316440588692_54","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1053\/j.pcsu.2009.01.004","article-title":"The first Stella van Praagh memorial lecture: the history and anatomy of tetralogy of Fallot","author":"Van Praagh, R.","year":"2009","unstructured":"[54] Van Praagh, R. The first Stella van Praagh memorial lecture: the history and anatomy of tetralogy of Fallot, Semin. Thorac. Cardiovasc. Surg. Pediatr. Card. Surg. Annu. (2009), pp. 19-38","journal-title":"Semin. Thorac. Cardiovasc. Surg. Pediatr. Card. Surg. Annu."},{"key":"key2025102316440588692_55","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ydbio.2005.05.003","article-title":"Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia","volume":"284","author":"Ward, C.","year":"2005","unstructured":"[55] Ward, C.; Stadt, H.; Hutson, M.; Kirby, M. L. Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia, Dev. Biol., Volume 284 (2005), pp. 72-83","journal-title":"Dev. Biol."},{"key":"key2025102316440588692_56","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ydbio.2007.09.023","article-title":"Myocardium at the base of the aorta and pulmonary trunk is prefigured in the outflow tract of the heart and in subdomains of the second heart field","volume":"313","author":"Bajolle, F.","year":"2008","unstructured":"[56] Bajolle, F.; Zaffran, S.; Meilhac, S. M.; Dandonneau, M.; Chang, T.; Kelly, R. G.; Buckingham, M. E. Myocardium at the base of the aorta and pulmonary trunk is prefigured in the outflow tract of the heart and in subdomains of the second heart field, Dev. Biol., Volume 313 (2008), pp. 25-34","journal-title":"Dev. Biol."},{"key":"key2025102316440588692_57","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1161\/CIRCRESAHA.122.320766","article-title":"PPARgamma and NOTCH regulate regional identity in the murine cardiac outflow tract","volume":"131","author":"Rammah, M.","year":"2022","unstructured":"[57] Rammah, M.; Theveniau-Ruissy, M.; Sturny, R.; Rochais, F.; Kelly, R. G. PPARgamma and NOTCH regulate regional identity in the murine cardiac outflow tract, Circ. Res., Volume 131 (2022), pp. 842-858","journal-title":"Circ. Res."},{"key":"key2025102316440588692_58","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1161\/01.RES.0000202800.85341.6e","article-title":"Rotation of the myocardial wall of the outflow tract is implicated in the normal positioning of the great arteries","volume":"98","author":"Bajolle, F.","year":"2006","unstructured":"[58] Bajolle, F.; Zaffran, S.; Kelly, R. G.; Hadchouel, J.; Bonnet, D.; Brown, N. A.; Buckingham, M. E. Rotation of the myocardial wall of the outflow tract is implicated in the normal positioning of the great arteries, Circ. Res., Volume 98 (2006), pp. 421-428","journal-title":"Circ. Res."},{"key":"key2025102316440588692_59","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1002\/dvdy.23833","article-title":"Morphogenesis of outflow tract rotation during cardiac development: the pulmonary push concept","volume":"241","author":"Scherptong, R. W.","year":"2012","unstructured":"[59] Scherptong, R. W.; Jongbloed, M. R.; Wisse, L. J.; Vicente-Steijn, R.; Bartelings, M. M.; Poelmann, R. E.; Schalij, M. J.; Gittenberger-De Groot, A. C. Morphogenesis of outflow tract rotation during cardiac development: the pulmonary push concept, Dev. Dyn., Volume 241 (2012), pp. 1413-1422","journal-title":"Dev. Dyn."},{"key":"key2025102316440588692_60","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41569-021-00587-4","article-title":"Genomic frontiers in congenital heart disease","volume":"19","author":"Morton, S. U.","year":"2022","unstructured":"[60] Morton, S. U.; Quiat, D.; Seidman, J. G.; Seidman, C. E. Genomic frontiers in congenital heart disease, Nat. Rev. Cardiol., Volume 19 (2022), pp. 26-42","journal-title":"Nat. Rev. Cardiol."},{"key":"key2025102316440588692_61","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1093\/cvr\/cvad059","article-title":"Charge syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression","volume":"119","author":"Stathopoulou, A.","year":"2023","unstructured":"[61] Stathopoulou, A.; Wang, P.; Thellier, C.; Kelly, R. G.; Zheng, D.; Scambler, P. J. Charge syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression, Cardiovasc. Res., Volume 119 (2023), pp. 2089-2105","journal-title":"Cardiovasc. Res."},{"key":"key2025102316440588692_62","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.152198","article-title":"Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors","volume":"7","author":"Tang, C. S. M.","year":"2022","unstructured":"[62] Tang, C. S. M.; Mononen, M.; Lam, W. Y.; Jin, S. C.; Zhuang, X.; Garcia-Barcelo, M. M.; Lin, Q.; Yang, Y.; Sahara, M.; Eroglu, E.; Chien, K. R.; Hong, H.; Tam, P. K. H.; Gruber, P. J. Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors, JCI Insight, Volume 7 (2022), e152198","journal-title":"JCI Insight"},{"key":"key2025102316440588692_63","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1242\/dev.136820","article-title":"Gestational stress induces the unfolded protein response, resulting in heart defects","volume":"143","author":"Shi, H.","year":"2016","unstructured":"[63] Shi, H.; O\u2019Reilly, V. C.; Moreau, J. L.; Bewes, T. R.; Yam, M. X.; Chapman, B. E.; Grieve, S. M.; Stocker, R.; Graham, R. M.; Chapman, G.; Sparrow, D. B.; Dunwoodie, S. L. Gestational stress induces the unfolded protein response, resulting in heart defects, Development, Volume 143 (2016), pp. 2561-2572","journal-title":"Development"},{"key":"key2025102316440588692_64","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23660-5","article-title":"Maternal iron deficiency perturbs embryonic cardiovascular development in mice","volume":"12","author":"Kalisch-Smith, J. I.","year":"2021","unstructured":"[64] Kalisch-Smith, J. I.; Ved, N.; Szumska, D.; Munro, J.; Troup, M.; Harris, S. E.; Rodriguez-Caro, H.; Jacquemot, A.; Miller, J. J.; Stuart, E. M.; Wolna, M.; Hardman, E.; Prin, F.; Lana-Elola, E.; Aoidi, R.; Fisher, E. M. C.; Tybulewicz, V. L. J.; Mohun, T. J.; Lakhal-Littleton, S.; De Val, S.; Giannoulatou, E.; Sparrow, D. B. Maternal iron deficiency perturbs embryonic cardiovascular development in mice, Nat. Commun., Volume 12 (2021), 3447","journal-title":"Nat. Commun."},{"key":"key2025102316440588692_65","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/bdr2.1968","article-title":"Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation","volume":"114","author":"Harvey, D. C.","year":"2022","unstructured":"[65] Harvey, D. C.; De Zoysa, P.; Toubat, O.; Choi, J.; Kishore, J.; Tsukamoto, H.; Kumar, S. R. Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation, Birth Defects Res., Volume 114 (2022), pp. 105-115","journal-title":"Birth Defects Res."},{"key":"key2025102316440588692_66","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.ydbio.2011.02.029","article-title":"Hox genes define distinct progenitor sub-domains within the second heart field","volume":"353","author":"Bertrand, N.","year":"2011","unstructured":"[66] Bertrand, N.; Roux, M.; Ryckebusch, L.; Niederreither, K.; Dolle, P.; Moon, A.; Capecchi, M.; Zaffran, S. Hox genes define distinct progenitor sub-domains within the second heart field, Dev. Biol., Volume 353 (2011), pp. 266-274","journal-title":"Dev. Biol."},{"key":"key2025102316440588692_67","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55124","article-title":"Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation","volume":"9","author":"Stefanovic, S.","year":"2020","unstructured":"[67] Stefanovic, S.; Laforest, B.; Desvignes, J. P.; Lescroart, F.; Argiro, L.; Maurel-Zaffran, C.; Salgado, D.; Plaindoux, E.; De Bono, C.; Pazur, K.; Theveniau-Ruissy, M.; Beroud, C.; Puceat, M.; Gavalas, A.; Kelly, R. G.; Zaffran, S. Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation, Elife, Volume 9 (2020), e55124","journal-title":"Elife"},{"key":"key2025102316440588692_68","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1161\/CIRCRESAHA.107.162206","article-title":"Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development","volume":"101","author":"Snarr, B. S.","year":"2007","unstructured":"[68] Snarr, B. S.; O\u2019Neal, J. L.; Chintalapudi, M. R.; Wirrig, E. E.; Phelps, A. L.; Kubalak, S. W.; Wessels, A. Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development, Circ. Res., Volume 101 (2007), pp. 971-974","journal-title":"Circ. Res."},{"key":"key2025102316440588692_69","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1242\/dev.016147","article-title":"Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart","volume":"135","author":"Goddeeris, M. M.","year":"2008","unstructured":"[69] Goddeeris, M. M.; Rho, S.; Petiet, A.; Davenport, C. L.; Johnson, G. A.; Meyers, E. N.; Klingensmith, J. Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart, Development, Volume 135 (2008), pp. 1887-1895","journal-title":"Development"},{"key":"key2025102316440588692_70","doi-asserted-by":"publisher","DOI":"10.1242\/dev.181719","article-title":"Planar cell polarity signaling regulates polarized second heart field morphogenesis to promote both arterial and venous pole septation","volume":"146","author":"Li, D.","year":"2019","unstructured":"[70] Li, D.; Angermeier, A.; Wang, J. Planar cell polarity signaling regulates polarized second heart field morphogenesis to promote both arterial and venous pole septation, Development, Volume 146 (2019), dev181719","journal-title":"Development"},{"key":"key2025102316440588692_71","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.diff.2012.05.006","article-title":"The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion","volume":"84","author":"Briggs, L. E.","year":"2012","unstructured":"[71] Briggs, L. E.; Kakarla, J.; Wessels, A. The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion, Differentiation: Res. Biol. Diversity, Volume 84 (2012), pp. 117-130","journal-title":"Differentiation: Res. Biol. Diversity"},{"key":"key2025102316440588692_72","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0092-8674(01)00493-7","article-title":"A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease","volume":"106","author":"Bruneau, B. G.","year":"2001","unstructured":"[72] Bruneau, B. G.; Nemer, G.; Schmitt, J. P.; Charron, F.; Robitaille, L.; Caron, S.; Conner, D. A.; Gessler, M.; Nemer, M.; Seidman, C. E.; Seidman, J. G. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease, Cell, Volume 106 (2001), pp. 709-721","journal-title":"Cell"},{"key":"key2025102316440588692_73","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.1093\/hmg\/ddy266","article-title":"T-box genes and retinoic acid signaling regulate the segregation of arterial and venous pole progenitor cells in the murine second heart field","volume":"27","author":"De Bono, C.","year":"2018","unstructured":"[73] De Bono, C.; Thellier, C.; Bertrand, N.; Sturny, R.; Jullian, E.; Cortes, C.; Stefanovic, S.; Zaffran, S.; Theveniau-Ruissy, M.; Kelly, R. G. T-box genes and retinoic acid signaling regulate the segregation of arterial and venous pole progenitor cells in the murine second heart field, Hum. Mol. Genet., Volume 27 (2018), pp. 3747-3760","journal-title":"Hum. Mol. Genet."},{"key":"key2025102316440588692_74","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/bs.ctdb.2016.08.008","article-title":"TBX5: a key regulator of heart development","volume":"122","author":"Steimle, J. D.","year":"2017","unstructured":"[74] Steimle, J. D.; Moskowitz, I. P. TBX5: a key regulator of heart development, Curr. Top. Dev. Biol., Volume 122 (2017), pp. 195-221","journal-title":"Curr. Top. Dev. Biol."},{"key":"key2025102316440588692_75","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69288","article-title":"Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development","volume":"10","author":"Rankin, S. A.","year":"2021","unstructured":"[75] Rankin, S. A.; Steimle, J. D.; Yang, X. H.; Rydeen, A. B.; Agarwal, K.; Chaturvedi, P.; Ikegami, K.; Herriges, M. J.; Moskowitz, I. P.; Zorn, A. M. Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development, Elife, Volume 10 (2021), e69288","journal-title":"Elife"},{"key":"key2025102316440588692_76","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.devcel.2012.06.006","article-title":"Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation","volume":"23","author":"Xie, L.","year":"2012","unstructured":"[76] Xie, L.; Hoffmann, A. D.; Burnicka-Turek, O.; Friedland-Little, J. M.; Zhang, K.; Moskowitz, I. P. Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation, Dev. Cell, Volume 23 (2012), pp. 280-291","journal-title":"Dev. Cell"},{"key":"key2025102316440588692_77","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nature12358","article-title":"Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor","volume":"500","author":"Peng, T.","year":"2013","unstructured":"[77] Peng, T.; Tian, Y.; Boogerd, C. J.; Lu, M. M.; Kadzik, R. S.; Stewart, K. M.; Evans, S. M.; Morrisey, E. E. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor, Nature, Volume 500 (2013), pp. 589-592","journal-title":"Nature"},{"key":"key2025102316440588692_78","doi-asserted-by":"publisher","first-page":"E10615","DOI":"10.1073\/pnas.1811624115","article-title":"Evolutionarily conserved Tbx5-Wnt2\/2b pathway orchestrates cardiopulmonary development","volume":"115","author":"Steimle, J. D.","year":"2018","unstructured":"[78] Steimle, J. D.; Rankin, S. A.; Slagle, C. E.; Bekeny, J.; Rydeen, A. B.; Chan, S. S.; Kweon, J.; Yang, X. H.; Ikegami, K.; Nadadur, R. D.; Rowton, M.; Hoffmann, A. D.; Lazarevic, S.; Thomas, W.; Boyle Anderson, E. A. T.; Horb, M. E.; Luna-Zurita, L.; Ho, R. K.; Kyba, M.; Jensen, B.; Zorn, A. M.; Conlon, F. L.; Moskowitz, I. P. Evolutionarily conserved Tbx5-Wnt2\/2b pathway orchestrates cardiopulmonary development, Proc. Natl. Acad. Sci. USA, Volume 115 (2018), p. E10615-E10624","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key2025102316440588692_79","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1016\/j.devcel.2022.08.009","article-title":"Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages","volume":"57","author":"Rowton, M.","year":"2022","unstructured":"[79] Rowton, M.; Perez-Cervantes, C.; Hur, S.; Jacobs-Li, J.; Lu, E.; Deng, N.; Guzzetta, A.; Hoffmann, A. D.; Stocker, M.; Steimle, J. D.; Lazarevic, S.; Oubaha, S.; Yang, X. H.; Kim, C.; Yu, S.; Eckart, H.; Koska, M.; Hanson, E.; Chan, S. S. K.; Garry, D. J.; Kyba, M.; Basu, A.; Ikegami, K.; Pott, S.; Moskowitz, I. P. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages, Dev. Cell, Volume 57 (2022), pp. 2181-2203","journal-title":"Dev. Cell"},{"key":"key2025102316440588692_80","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nature08324","article-title":"Reptilian heart development and the molecular basis of cardiac chamber evolution","volume":"461","author":"Koshiba-Takeuchi, K.","year":"2009","unstructured":"[80] Koshiba-Takeuchi, K.; Mori, A. D.; Kaynak, B. L.; Cebra-Thomas, J.; Sukonnik, T.; Georges, R. O.; Latham, S.; Beck, L.; Henkelman, R. M.; Black, B. L.; Olson, E. N.; Wade, J.; Takeuchi, J. K.; Nemer, M.; Gilbert, S. F.; Bruneau, B. G. Reptilian heart development and the molecular basis of cardiac chamber evolution, Nature, Volume 461 (2009), pp. 95-98","journal-title":"Nature"},{"key":"key2025102316440588692_81","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.devcel.2020.11.020","article-title":"Modeling human TBX5 haploinsufficiency predicts regulatory networks for congenital heart disease","volume":"56","author":"Kathiriya, I. S.","year":"2021","unstructured":"[81] Kathiriya, I. S.; Rao, K. S.; Iacono, G.; Devine, W. P.; Blair, A. P.; Hota, S. K.; Lai, M. H.; Garay, B. I.; Thomas, R.; Gong, H. Z.; Wasson, L. K.; Goyal, P.; Sukonnik, T.; Hu, K. M.; Akgun, G. A.; Bernard, L. D.; Akerberg, B. N.; Gu, F.; Li, K.; Speir, M. L.; Haeussler, M.; Pu, W. T.; Stuart, J. M.; Seidman, C. E.; Seidman, J. G.; Heyn, H.; Bruneau, B. G. Modeling human TBX5 haploinsufficiency predicts regulatory networks for congenital heart disease, Dev. Cell, Volume 56 (2021), pp. 292-309","journal-title":"Dev. Cell"},{"key":"key2025102316440588692_82","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/ije\/dyz009","article-title":"Global birth prevalence of congenital heart defects 1970\u20132017: updated systematic review and meta-analysis of 260 studies","volume":"48","author":"Liu, Y.","year":"2019","unstructured":"[82] Liu, Y.; Chen, S.; Zuhlke, L.; Black, G. C.; Choy, M. K.; Li, N.; Keavney, B. D. Global birth prevalence of congenital heart defects 1970\u20132017: updated systematic review and meta-analysis of 260 studies, Int. J. Epidemiol., Volume 48 (2019), pp. 455-463","journal-title":"Int. J. Epidemiol."},{"key":"key2025102316440588692_83","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.stem.2020.10.013","article-title":"Capturing cardiogenesis in gastruloids","volume":"28","author":"Rossi, G.","year":"2021","unstructured":"[83] Rossi, G.; Broguiere, N.; Miyamoto, M.; Boni, A.; Guiet, R.; Girgin, M.; Kelly, R. G.; Kwon, C.; Lutolf, M. P. Capturing cardiogenesis in gastruloids, Cell. Stem Cell, Volume 28 (2021), pp. 230-240 (e236)","journal-title":"Cell. Stem Cell"}],"container-title":["Comptes Rendus. Biologies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/comptes-rendus.academie-sciences.fr\/biologies\/item\/10.5802\/crbiol.151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T15:00:12Z","timestamp":1761231612000},"score":1,"resource":{"primary":{"URL":"https:\/\/comptes-rendus.academie-sciences.fr\/biologies\/articles\/10.5802\/crbiol.151\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":83,"journal-issue":{"issue":"G1","published-online":{"date-parts":[[2024]]}},"alternative-id":["10.5802\/crbiol.151"],"URL":"https:\/\/doi.org\/10.5802\/crbiol.151","relation":{"has-translation":[{"id-type":"doi","id":"10.5802\/crbiol.151-fr","asserted-by":"object"}]},"ISSN":["1631-0691","1768-3238"],"issn-type":[{"value":"1631-0691","type":"print"},{"value":"1768-3238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]}}}