{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:20:56Z","timestamp":1790824856038,"version":"4.1.0"},"reference-count":38,"publisher":"MathDoc\/Centre Mersenne","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    We established the COVID Human Genetic Effort (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.covidhge.com\">www.covidhge.com<\/jats:ext-link>\n                    ) to discover the human genetic and immunological bases of the vast interindividual clinical variability between humans infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We found that about 3% of patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia were ill because of inborn errors of genes controlling type I interferon (IFN)-dependent immunity (which controls influenza virus), and at least 10% of patients with life-threatening COVID-19 pneumonia had neutralizing auto-Abs against some of the 17 individual type I IFNs. These findings indicate that impaired type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 13% of patients. These discoveries pave the way for further research into unexplained severe cases, and provide a rationale for preventing and treating the disease in individuals at risk, with recombinant type I IFNs.\n                  <\/jats:p>","DOI":"10.5802\/crbiol.36","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T12:10:59Z","timestamp":1612872659000},"page":"19-25","source":"Crossref","is-referenced-by-count":28,"title":["Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumonia"],"prefix":"10.5802","volume":"344","author":[{"given":"Paul","family":"Bastard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Cobat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Jouanguy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"issue":"5","key":"key2025102316425978454_1","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.cell.2020.08.021","article-title":"Emerging pandemic diseases: how we got to COVID-19","volume":"182","author":"Morens, D. M.","year":"2020","unstructured":"[1] Morens, D. M.; Fauci, A. S. Emerging pandemic diseases: how we got to COVID-19, Cell, Volume 182 (2020) no. 5, pp. 1077-1092","journal-title":"Cell"},{"issue":"10247","key":"key2025102316425978454_2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0140-6736(20)31304-0","article-title":"Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study","volume":"396","author":"Stringhini, S.","year":"2020","unstructured":"[2] Stringhini, S.; Wisniak, A.; Piumatti, G.; Azman, A. S.; Lauer, S. A. et al. Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study, Lancet, Volume 396 (2020) no. 10247, pp. 313-319","journal-title":"Lancet"},{"key":"key2025102316425978454_3","first-page":"14","article-title":"Epidemiological, genetic, and immunological bases of life-threatening COVID-19","volume":"1","author":"Zhang, Q.","year":"2020","unstructured":"[3] Zhang, Q.; Bastard, P.; Liu, Z.; Le Pen, J.; Moncada-Velez, M.; Chen, J.; Ogishi, M. et al. Epidemiological, genetic, and immunological bases of life-threatening COVID-19, Med, Volume 1 (2020), pp. 14-32","journal-title":"Med"},{"issue":"9","key":"key2025102316425978454_4","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.22310","article-title":"Risk factors for hospitalization, mechanical ventilation, or death among 10131 US veterans with SARS-CoV-2 infection","volume":"3","author":"Ioannou, G. N.","year":"2020","unstructured":"[4] Ioannou, G. N.; Locke, E.; Green, P.; Berry, K.; O\u2019Hare, A. M.; Shah, J. A.; Crothers, K.; Eastment, M. C.; Dominitz, J. A.; Fan, V. S. Risk factors for hospitalization, mechanical ventilation, or death among 10131 US veterans with SARS-CoV-2 infection, JAMA Netw. Open., Volume 3 (2020) no. 9, e2022310","journal-title":"JAMA Netw. Open."},{"key":"key2025102316425978454_5","article-title":"Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study","volume":"369","author":"Docherty, A. B.","year":"2020","unstructured":"[5] Docherty, A. B.; Harrison, E. M.; Green, C. A.; Hardwick, H. E. et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study, BMJ, Volume 369 (2020), m1985","journal-title":"BMJ"},{"key":"key2025102316425978454_6","article-title":"Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study","volume":"369","author":"Petrilli, C. M.","year":"2020","unstructured":"[6] Petrilli, C. M.; Jones, S. A.; Yang, J.; Rajagopalan, H.; O\u2019Donnell, L.; Chernyak, Y.; Tobin, K. A.; Cerfolio, R. J.; Francois, F.; Horwitz, L. I. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study, BMJ, Volume 369 (2020), m1966","journal-title":"BMJ"},{"issue":"6","key":"key2025102316425978454_7","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2020.05.016","article-title":"A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection","volume":"181","author":"Casanova, J. L.","year":"2020","unstructured":"[7] Casanova, J. L.; Su, H. C.; Effort, C. H. G. A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection, Cell, Volume 181 (2020) no. 6, pp. 1194-1199","journal-title":"Cell"},{"issue":"6-7","key":"key2025102316425978454_8","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s00439-020-02184-w","article-title":"The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?","volume":"139","author":"Casanova, J. L.","year":"2020","unstructured":"[8] Casanova, J. L.; Abel, L. The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?, Hum. Genet., Volume 139 (2020) no. 6-7, pp. 681-694","journal-title":"Hum. 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Inborn errors of type I IFN immunity in patients with life-threatening COVID-19, Science, Volume 370 (2020), eabd4570","journal-title":"Science"},{"issue":"1","key":"key2025102316425978454_28","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1086\/380453","article-title":"Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity","volume":"38","author":"Doffinger, R.","year":"2004","unstructured":"[28] Doffinger, R.; Helbert, M. R.; Barcenas-Morales, G.; Yang, K.; Dupuis, S.; Ceron-Gutierrez, L. et al. Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity, Clin. Infect. Dis., Volume 38 (2004) no. 1, p. e10-e14","journal-title":"Clin. Infect. 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