{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:34:38Z","timestamp":1790674478281,"version":"4.1.0"},"reference-count":34,"publisher":"MathDoc\/Centre Mersenne","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Huntington\u2019s disease is a rare inherited neurological disorder that generally manifests in mild-adulthood. The disease is characterized by the dysfunction and the degeneration of specific brain structures leading progressively to psychiatric, cognitive and motor disorders. The disease is caused by a mutation in the gene coding for huntingtin and, although it appears in adulthood, embryos carry the mutated gene from their development\n                    <jats:italic>in utero<\/jats:italic>\n                    . Studies based on mouse models and human stem cells have reported altered developmental mechanisms in disease conditions. However, does the mutation affect development in humans? Focusing on the early stages of brain development in human fetuses carrying the HD mutation, we have identified abnormalities in the development of the neocortex, the structure that ensure higher cerebral functions. Altogether, these studies suggests that developmental defects could contribute to the onset symptoms in adults, changing the perspective on disease and thus the health care of patients.\n                  <\/jats:p>","DOI":"10.5802\/crbiol.93","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T06:37:28Z","timestamp":1666766248000},"page":"77-90","source":"Crossref","is-referenced-by-count":5,"title":["Huntington\u2019s disease and brain development"],"prefix":"10.5802","volume":"345","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-2658","authenticated-orcid":false,"given":"Sandrine","family":"Humbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4653-3254","authenticated-orcid":false,"given":"Monia","family":"Barnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"issue":"5","key":"key2025102316432646913_1","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The biology of huntingtin","volume":"89","author":"Saudou, F.","year":"2016","unstructured":"[1] Saudou, F.; Humbert, S. The biology of huntingtin, Neuron, Volume 89 (2016) no. 5, pp. 910-926","journal-title":"Neuron"},{"issue":"1","key":"key2025102316432646913_2","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier, L. R.","year":"2004","unstructured":"[2] Gauthier, L. R.; Charrin, B. C.; Borrell-Pag\u00e8s, M.; Dompierre, J. P.; Rangone, H.; Cordeli\u00e8res, F. P.; De Mey, J.; MacDonald, M. E.; Lessmann, V.; Humbert, S.; Saudou, F. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules, Cell, Volume 118 (2004) no. 1, pp. 127-138","journal-title":"Cell"},{"issue":"5222","key":"key2025102316432646913_3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1126\/science.7618107","article-title":"Inactivation of the mouse Huntington\u2019s disease gene homolog Hdh","volume":"269","author":"Duyao, M. P.","year":"1995","unstructured":"[3] Duyao, M. P.; Auerbach, A. B.; Ryan, A.; Persichetti, F.; Barnes, G. T.; McNeil, S. M.; Ge, P.; Vonsattel, J. P.; Gusella, J. F.; Joyner, A. L. Inactivation of the mouse Huntington\u2019s disease gene homolog Hdh, Science, Volume 269 (1995) no. 5222, pp. 407-410","journal-title":"Science"},{"issue":"2","key":"key2025102316432646913_4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/ng1095-155","article-title":"Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington\u2019s disease gene homologue","volume":"11","author":"Zeitlin, S.","year":"1995","unstructured":"[4] Zeitlin, S.; Liu, J. P.; Chapman, D. L.; Papaioannou, V. E.; Efstratiadis, A. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington\u2019s disease gene homologue, Nat. Genet., Volume 11 (1995) no. 2, pp. 155-163","journal-title":"Nat. Genet."},{"issue":"4","key":"key2025102316432646913_5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/ng1297-404","article-title":"Huntingtin is required for neurogenesis and is not impaired by the Huntington\u2019s disease CAG expansion","volume":"17","author":"White, J. K.","year":"1997","unstructured":"[5] White, J. K.; Auerbach, W.; Duyao, M. P.; Vonsattel, J. P.; Gusella, J. F.; Joyner, A. L.; MacDonald, M. E. Huntingtin is required for neurogenesis and is not impaired by the Huntington\u2019s disease CAG expansion, Nat. Genet., Volume 17 (1997) no. 4, pp. 404-410","journal-title":"Nat. Genet."},{"issue":"5","key":"key2025102316432646913_6","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nn.3080","article-title":"An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin","volume":"15","author":"Lo Sardo, V.","year":"2012","unstructured":"[6] Lo Sardo, V.; Zuccato, C.; Gaudenzi, G.; Vitali, B.; Ramos, C.; Tartari, M.; Myre, M. A.; Walker, J. A.; Pistocchi, A.; Conti, L.; Valenza, M.; Drung, B.; Schmidt, B.; Gusella, J.; Zeitlin, S.; Cotelli, F.; Cattaneo, E. An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin, Nat. Neurosci., Volume 15 (2012) no. 5, pp. 713-721","journal-title":"Nat. Neurosci."},{"issue":"10","key":"key2025102316432646913_7","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1038\/s41587-019-0237-5","article-title":"Self-organizing neuruloids model developmental aspects of Huntington\u2019s disease in the ectodermal compartment","volume":"37","author":"Haremaki, T.","year":"2019","unstructured":"[7] Haremaki, T.; Metzger, J. J.; Rito, T.; Ozair, M. Z.; Etoc, F.; Brivanlou, A. H. Self-organizing neuruloids model developmental aspects of Huntington\u2019s disease in the ectodermal compartment, Nat. Biotechnol., Volume 37 (2019) no. 10, pp. 1198-1208","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"key2025102316432646913_8","doi-asserted-by":"publisher","first-page":"E762","DOI":"10.1073\/pnas.1715865115","article-title":"Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes","volume":"115","author":"Conforti, P.","year":"2018","unstructured":"[8] Conforti, P.; Besusso, D.; Bocchi, V. D.; Faedo, A.; Cesana, E.; Rossetti, G.; Ranzani, V.; Svendsen, C. N.; Thompson, L. M.; Toselli, M.; Biella, G.; Pagani, M.; Cattaneo, E. Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes, Proc. Natl. Acad. Sci. USA, Volume 115 (2018) no. 4, p. E762-E771","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"key2025102316432646913_9","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.celrep.2018.09.076","article-title":"Human Huntington\u2019s disease iPSC-derived cortical neurons display altered transcriptomics, morphology, and maturation","volume":"25","author":"Mehta, S. R.","year":"2018","unstructured":"[9] Mehta, S. R.; Tom, C. M.; Wang, Y.; Bresee, C.; Rushton, D.; Mathkar, P. P.; Tang, J.; Mattis, V. B. Human Huntington\u2019s disease iPSC-derived cortical neurons display altered transcriptomics, morphology, and maturation, Cell Rep., Volume 25 (2018) no. 4, pp. 1081-1096 (e6)","journal-title":"Cell Rep."},{"issue":"19","key":"key2025102316432646913_10","doi-asserted-by":"publisher","first-page":"7608","DOI":"10.1523\/JNEUROSCI.21-19-07608.2001","article-title":"Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice","volume":"21","author":"Reiner, A.","year":"2001","unstructured":"[10] Reiner, A.; Del Mar, N.; Meade, C. A.; Yang, H.; Dragatsis, I.; Zeitlin, S.; Goldowitz, D. 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C.; investigators, TRACK-HD Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data, Lancet Neurol., Volume 8 (2009) no. 9, pp. 791-801","journal-title":"Lancet Neurol."},{"issue":"7","key":"key2025102316432646913_12","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1212\/WNL.0b013e3182648b65","article-title":"Measures of growth in children at risk for Huntington disease","volume":"79","author":"Lee, J. K.","year":"2012","unstructured":"[12] Lee, J. K.; Mathews, K.; Schlaggar, B.; Perlmutter, J.; Paulsen, J. S.; Epping, E.; Burmeister, L.; Nopoulos, P. Measures of growth in children at risk for Huntington disease, Neurology, Volume 79 (2012) no. 7, pp. 668-674","journal-title":"Neurology"},{"key":"key2025102316432646913_13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.nbd.2016.09.006","article-title":"Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington\u2019s disease","volume":"96","author":"Arteaga-Bracho, E. E.","year":"2016","unstructured":"[13] Arteaga-Bracho, E. E.; Gulinello, M.; Winchester, M. L.; Pichamoorthy, N.; Petronglo, J. R.; Zambrano, A. D.; Inocencio, J.; De Jesus, C. D.; Louie, J. O.; Gokhan, S.; Mehler, M. F.; Molero, A. E. Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington\u2019s disease, Neurobiol. Dis., Volume 96 (2016), pp. 144-155","journal-title":"Neurobiol. Dis."},{"issue":"20","key":"key2025102316432646913_14","doi-asserted-by":"publisher","first-page":"5736","DOI":"10.1073\/pnas.1603871113","article-title":"Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington\u2019s disease","volume":"113","author":"Molero, A. E.","year":"2016","unstructured":"[14] Molero, A. E.; Arteaga-Bracho, E. E.; Chen, C. H.; Gulinello, M.; Winchester, M. L.; Pichamoorthy, N.; Gokhan Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington\u2019s disease, Proc. Natl. Acad. Sci. USA, Volume 113 (2016) no. 20, pp. 5736-5741","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key2025102316432646913_15","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00082","article-title":"Cortical and striatal circuits in Huntington\u2019s disease","volume":"14","author":"Blumenstock, S.","year":"2020","unstructured":"[15] Blumenstock, S.; Dudanova, I. Cortical and striatal circuits in Huntington\u2019s disease, Front. Neurosci., Volume 14 (2020), 82","journal-title":"Front. Neurosci."},{"issue":"2","key":"key2025102316432646913_16","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/nn1172","article-title":"Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases","volume":"7","author":"Noctor, S. C.","year":"2004","unstructured":"[16] Noctor, S. C.; Mart\u00ednez-Cerde\u00f1o, V.; Ivic, L.; Kriegstein, A. R. Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases, Nat. Neurosci., Volume 7 (2004) no. 2, pp. 136-144","journal-title":"Nat. Neurosci."},{"issue":"11","key":"key2025102316432646913_17","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/s41582-020-0395-6","article-title":"International consensus recommendations on the diagnostic work-up for malformations of cortical development","volume":"16","author":"Oegema, R.","year":"2020","unstructured":"[17] Oegema, R.; Barakat, T. S.; Wilke, M.; Stouffs, K.; Amrom, D.; Aronica, E.; Bahi-Buisson, N.; Conti, V.; Fry, A. E.; Geis, T.; Gomez Andrez, D.; Parrini, E.; Pogledic, I.; Said, E.; Soler, D.; Valor, L. M.; Zaki, M. S.; Mirzaa, G.; Dobyns, W. B.; Reiner, O.; Guerrini, R.; Pilz, D. T.; Hehr, U.; Leventer, R. J.; Jansen, A. C.; Mancini, G. M. S.; Di Donato, N. International consensus recommendations on the diagnostic work-up for malformations of cortical development, Nat. Rev. Neurol., Volume 16 (2020) no. 11, pp. 618-635","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"key2025102316432646913_18","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.neuron.2010.06.027","article-title":"Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis","volume":"67","author":"Godin, J. D.","year":"2010","unstructured":"[18] Godin, J. D.; Colombo, K.; Molina-Calavita, M.; Keryer, G.; Zala, D.; Charrin, B. C.; Dietrich, P.; Volvert, M.-L.; Guillemot, F.; Dragatsis, I.; Bellaiche, Y.; Saudou, F.; Nguyen, L.; Humbert, S. Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis, Neuron, Volume 67 (2010) no. 3, pp. 392-406","journal-title":"Neuron"},{"issue":"30","key":"key2025102316432646913_19","doi-asserted-by":"publisher","first-page":"10034","DOI":"10.1523\/JNEUROSCI.0715-14.2014","article-title":"Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex","volume":"34","author":"Molina-Calavita, M.","year":"2014","unstructured":"[19] Molina-Calavita, M.; Barnat, M.; Elias, S.; Aparicio, E.; Piel, M.; Humbert, S. Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex, J.\u00a0Neurosci., Volume 34 (2014) no. 30, pp. 10034-10040","journal-title":"J.\u00a0Neurosci."},{"issue":"41","key":"key2025102316432646913_20","doi-asserted-by":"publisher","first-page":"14794","DOI":"10.1523\/JNEUROSCI.2774-11.2011","article-title":"Spatial and temporal requirements for huntingtin (Htt) in neuronal migration and survival during brain development","volume":"31","author":"Tong, Y.","year":"2011","unstructured":"[20] Tong, Y.; Ha, T. J.; Liu, L.; Nishimoto, A.; Reiner, A.; Goldowitz, D. Spatial and temporal requirements for huntingtin (Htt) in neuronal migration and survival during brain development, J.\u00a0Neurosci., Volume 31 (2011) no. 41, pp. 14794-14799","journal-title":"J.\u00a0Neurosci."},{"issue":"1","key":"key2025102316432646913_21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neuron.2016.11.035","article-title":"Huntingtin-mediated multipolar-bipolar transition of newborn cortical neurons is critical for their postnatal neuronal morphology","volume":"93","author":"Barnat, M.","year":"2017","unstructured":"[21] Barnat, M.; Le Friec, J.; Benstaali, C.; Humbert, S. Huntingtin-mediated multipolar-bipolar transition of newborn cortical neurons is critical for their postnatal neuronal morphology, Neuron, Volume 93 (2017) no. 1, pp. 99-114","journal-title":"Neuron"},{"issue":"28","key":"key2025102316432646913_22","doi-asserted-by":"publisher","first-page":"9455","DOI":"10.1523\/JNEUROSCI.4699-13.2014","article-title":"Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits","volume":"34","author":"McKinstry, S. U.","year":"2014","unstructured":"[22] McKinstry, S. U.; Karadeniz, Y. B.; Worthington, A. K.; Hayrapetyan, V. Y.; Ozlu, M. I.; Serafin-Molina, K.; Risher, W. C.; Ustunkaya, T.; Dragatsis, I.; Zeitlin, S.; Yin, H. H.; Eroglu, C. Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits, J.\u00a0Neurosci., Volume 34 (2014) no. 28, pp. 9455-9472","journal-title":"J.\u00a0Neurosci."},{"issue":"9","key":"key2025102316432646913_23","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111261","article-title":"Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton","volume":"40","author":"Wennagel, D.","year":"2022","unstructured":"[23] Wennagel, D.; Braz, B. Y.; Capizzi, M.; Barnat, M.; Humbert, S. Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton, Cell Rep., Volume 40 (2022) no. 9, 111261","journal-title":"Cell Rep."},{"issue":"1","key":"key2025102316432646913_24","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.neuron.2021.10.033","article-title":"Developmental defects in Huntington\u2019s disease show that axonal growth and microtubule reorganization require NUMA1","volume":"110","author":"Capizzi, M.","year":"2022","unstructured":"[24] Capizzi, M.; Carpentier, R.; Denarier, E.; Adrait, A.; Kassem, R.; Mapelli, M.; Cout\u00e9, Y.; Humbert, S. Developmental defects in Huntington\u2019s disease show that axonal growth and microtubule reorganization require NUMA1, Neuron, Volume 110 (2022) no. 1, pp. 36-50 (e5)","journal-title":"Neuron"},{"issue":"6","key":"key2025102316432646913_25","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.stemcr.2015.11.005","article-title":"Genomic analysis reveals disruption of striatal neuronal development and therapeutic targets in human Huntington\u2019s disease neural stem cells","volume":"5","author":"Ring, K. L.","year":"2015","unstructured":"[25] Ring, K. L.; An, M. C.; Zhang, N.; O\u2019Brien, R. N.; Ramos, E. M.; Gao, F.; Atwood, R.; Bailus, B. J.; Melov, S.; Mooney, S. D.; Coppola, G.; Ellerby, L. M. Genomic analysis reveals disruption of striatal neuronal development and therapeutic targets in human Huntington\u2019s disease neural stem cells, Stem Cell Rep., Volume 5 (2015) no. 6, pp. 1023-1038","journal-title":"Stem Cell Rep."},{"issue":"5","key":"key2025102316432646913_26","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nn.4532","article-title":"Developmental alterations in Huntington\u2019s disease neural cells and pharmacological rescue in cells and mice","volume":"20","author":"HD iPSC Consortium","year":"2017","unstructured":"[26] HD iPSC Consortium Developmental alterations in Huntington\u2019s disease neural cells and pharmacological rescue in cells and mice, Nat. Neurosci., Volume 20 (2017) no. 5, pp. 648-660","journal-title":"Nat. Neurosci."},{"issue":"3","key":"key2025102316432646913_27","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00401-021-02269-4","article-title":"Developmental malformations in Huntington disease: neuropathologic evidence of focal neuronal migration defects in a subset of adult brains","volume":"141","author":"Hickman, R. A.","year":"2021","unstructured":"[27] Hickman, R. A.; Faust, P. L.; Rosenblum, M. K.; Marder, K.; Mehler, M. F.; Vonsattel, J. P. Developmental malformations in Huntington disease: neuropathologic evidence of focal neuronal migration defects in a subset of adult brains, Acta Neuropathol. (Berl), Volume 141 (2021) no. 3, pp. 399-413","journal-title":"Acta Neuropathol. (Berl)"},{"issue":"6505","key":"key2025102316432646913_28","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1126\/science.aax3338","article-title":"Huntington\u2019s disease alters human neurodevelopment","volume":"369","author":"Barnat, M.","year":"2020","unstructured":"[28] Barnat, M.; Capizzi, M.; Aparicio, E.; Boluda, S.; Wennagel, D.; Kacher, R.; Kassem, R.; Lenoir, S.; Agasse, F.; Braz, B. Y.; Liu, J.-P.; Ighil, J.; Tessier, A.; Zeitlin, S. O.; Duyckaerts, C.; Dommergues, M.; Durr, A.; Humbert, S. Huntington\u2019s disease alters human neurodevelopment, Science, Volume 369 (2020) no. 6505, pp. 787-793","journal-title":"Science"},{"issue":"3","key":"key2025102316432646913_29","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.molcel.2017.10.001","article-title":"Genetically encoded tools for optical dissection of the mammalian cell cycle","volume":"68","author":"Sakaue-Sawano, A.","year":"2017","unstructured":"[29] Sakaue-Sawano, A.; Yo, M.; Komatsu, N.; Hiratsuka, T.; Kogure, T.; Hoshida, T.; Goshima, N.; Matsuda, M.; Miyoshi, H.; Miyawaki, A. Genetically encoded tools for optical dissection of the mammalian cell cycle, Mol. Cell, Volume 68 (2017) no. 3, pp. 626-640 (e5)","journal-title":"Mol. Cell"},{"issue":"1","key":"key2025102316432646913_30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ydbio.2012.06.031","article-title":"Apical movement during interkinetic nuclear migration is a two-step process","volume":"370","author":"Spear, P. C.","year":"2012","unstructured":"[30] Spear, P. C.; Erickson, C. A. Apical movement during interkinetic nuclear migration is a two-step process, Dev. Biol., Volume 370 (2012) no. 1, pp. 33-41","journal-title":"Dev. Biol."},{"key":"key2025102316432646913_31","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1155","article-title":"Neural stem and progenitor cells shorten S-phase on commitment to neuron production","volume":"2","author":"Arai, Y.","year":"2011","unstructured":"[31] Arai, Y.; Pulvers, J. N.; Haffner, C.; Schilling, B.; N\u00fcsslein, I.; Calegari, F.; Huttner, W. B. Neural stem and progenitor cells shorten S-phase on commitment to neuron production, Nat. Commun., Volume 2 (2011), 154","journal-title":"Nat. Commun."},{"issue":"5","key":"key2025102316432646913_32","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.celrep.2017.07.018","article-title":"Loss of brap results in premature G1\/S phase transition and impeded neural progenitor differentiation","volume":"20","author":"Lanctot, A. A.","year":"2017","unstructured":"[32] Lanctot, A. A.; Guo, Y.; Le, Y.; Edens, B. M.; Nowakowski, R. S.; Feng, Y. Loss of brap results in premature G1\/S phase transition and impeded neural progenitor differentiation, Cell Rep., Volume 20 (2017) no. 5, pp. 1148-1160","journal-title":"Cell Rep."},{"issue":"1","key":"key2025102316432646913_33","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1242\/dev.069294","article-title":"Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination","volume":"139","author":"Wilsch-Br\u00e4uninger, M.","year":"2012","unstructured":"[33] Wilsch-Br\u00e4uninger, M.; Peters, J.; Paridaen, J. T. M. L.; Huttner, W. B. Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination, Development, Volume 139 (2012) no. 1, pp. 95-105","journal-title":"Development"},{"issue":"5","key":"key2025102316432646913_34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002142","article-title":"Huntingtin is required for epithelial polarity through RAB11A-mediated apical trafficking of PAR3-aPKC","volume":"13","author":"Elias, S.","year":"2015","unstructured":"[34] Elias, S.; McGuire, J. R.; Yu, H.; Humbert, S. Huntingtin is required for epithelial polarity through RAB11A-mediated apical trafficking of PAR3-aPKC, PLoS Biol., Volume 13 (2015) no. 5, e1002142","journal-title":"PLoS Biol."}],"container-title":["Comptes Rendus. 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