{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:31:56Z","timestamp":1790951516678,"version":"4.1.0"},"reference-count":13,"publisher":"California Digital Library (CDL)","issue":"1","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Transfusion-related acute lung injury (TRALI) is a complication of blood product transfusion characterized by respiratory distress with bilateral lung infiltrates and non-cardiogenic pulmonary edema developing within six hours of transfusion. TRALI is believed to result from an immunological response to transfused blood products. TRALI is a clinical diagnosis that requires the exclusion of other etiologies of pulmonary edema and acute lung injury. Here we report a case of a female who presented to the emergency department in acute respiratory distress two days after receiving a transfusion of packed red blood cells for post-operative anemia following a hysterectomy.<\/jats:p>","DOI":"10.5811\/cpcem.2018.11.40592","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T20:22:07Z","timestamp":1551126127000},"page":"33-35","source":"Crossref","is-referenced-by-count":4,"title":["Late Presentation of Transfusion-related Acute Lung Injury in the Emergency Department"],"prefix":"10.5811","volume":"3","author":[{"given":"David","family":"Peak","sequence":"first","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium, Department of Emergency Medicine, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Davis","sequence":"additional","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium, Department of Emergency Medicine, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Walton","sequence":"additional","affiliation":[{"name":"San Antonio Uniformed Services Health Education Consortium, Department of Emergency Medicine, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"29705","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"ref0","unstructured":"U.S. Food and Drug Administration. Fatalities Reported to FDA Following Blood Collection and Transfusion Annual Summary for FY2016. Food and Drug Administration Center for Biologics Evaluation and Research. Available at: https:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/SafetyAvailability\/ReportaProblem\/TransfusionDonationFatalities\/UCM598243.pdf. Accessed October 29, 2018."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Sayah DM, Looney MR, Toy P. Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury. Crit Care Clin. 2012;28(3):363-72.","DOI":"10.1016\/j.ccc.2012.04.001"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Popovsky MA. Transfusion-related acute lung injury: incidence, pathogenesis and the role of multicomponent apheresis in its prevention. Transfus Med Hemother. 2008;35(2):76-9.","DOI":"10.1159\/000117811"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Sokolovic M and Pastores SM. Transfusion therapy and acute lung injury. Expert Rev Respir Med. 2010;4(3):387-93.","DOI":"10.1586\/ers.10.22"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Toy P and Lowell C. TRALI - Definition, mechanisms, incidence and clinical relevance. Best Pract Res Clin Anaesthesiol. 2007;21(2):183-93.","DOI":"10.1016\/j.bpa.2007.01.003"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Triulzi DJ. Transfusion-related acute lung injury: current concepts for the clinician. Anesth Analg. 2009;108(3):770-6.","DOI":"10.1213\/ane.0b013e31819029b2"},{"key":"ref6","unstructured":"Robillard P, Hyson C, McCombie N. TRALI, possible TRALI and respiratory complications of transfusion reported to the Canadian Transfusion Transmitted Injuries Surveillance System. 60th Annual Meeting of the American-Association-of-Blood-Banks. 2007."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Kopko PM, Paglieroni TG, Popovsky MA, et al. TRALI: correlation of antigen-antibody and monocyte activation in donor-recipient pairs. Transfusion. 2003;43(2):177-84.","DOI":"10.1046\/j.1537-2995.2003.00307.x"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Sachs UJ. Recent insights into the mechanism of transfusion-related acute lung injury. Curr Opin Hematol. 2011;18(6):436-42.","DOI":"10.1097\/MOH.0b013e32834bab01"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Gajic O, Gropper MA, Hubmayr RD. Pulmonary edema after transfusion: how to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Crit Care Med. 2006;34(5 Suppl):S109-13.","DOI":"10.1097\/01.ccm.0000214311.56231.23"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Goldberg AD and Kor DJ. State of the art management of transfusion-related acute lung injury (TRALI). Curr Pharm Des. 2012;18(22):3273-84.","DOI":"10.2174\/1381612811209023273"},{"key":"ref11","unstructured":"Cho MS and Sharma S. Transfusion-related acute lung injury (TRALI). StatPearls. Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507846\/. Accessed October 29, 2018."},{"key":"ref12","unstructured":"Vlaar AP, Schultz MJ, Juffermans NP. Transfusion-related acute lung injury: a change of perspective. Neth J Med. 2009;67(10):320-6."}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T18:35:20Z","timestamp":1551378920000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/5rs1z74g"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,7]]},"references-count":13,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2018.11.40592","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"value":"2474-252X","type":"electronic"},{"value":"2474-252X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,7]]}}}