{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:52:12Z","timestamp":1726505532122},"reference-count":12,"publisher":"California Digital Library (CDL)","issue":"3","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We describe the case of a patient presenting with odd neurologic symptoms initially thought to represent somatization who was found to have critical hypokalemia manifesting as hypokalemic non-periodic paralysis. It was determined that the patient had baseline hypokalemia as a function of alcohol abuse, exacerbated by self overmedication with hydrochlorothiazide for elevated blood pressure readings at home. The diagnosis was suspected when an electrocardiogram was obtained demonstrating a pseudo-prolonged QT interval with ST depression, consistent with T-U wave fusion and a QU interval with an absent T wave.1 The patient received oral and intravenous potassium and magnesium supplementation with resolution of symptoms.<\/jats:p>","DOI":"10.5811\/cpcem.2019.3.42062","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T01:31:17Z","timestamp":1564623077000},"page":"211-214","source":"Crossref","is-referenced-by-count":2,"title":["A Case of Thiazide-induced Hypokalemic Paralysis"],"prefix":"10.5811","volume":"3","author":[{"given":"Elizabeth","family":"Schell","sequence":"first","affiliation":[{"name":"Drexel University College of Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Pathman","sequence":"additional","affiliation":[{"name":"Crozer-Keystone Health System, Department of Emergency Medicine, Upland, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Pescatore","sequence":"additional","affiliation":[{"name":"Crozer-Keystone Health System, Department of Emergency Medicine, Upland, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pollianne","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Crozer-Keystone Health System, Department of Emergency Medicine, Upland, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Levis JT. ECG diagnosis: hypokalemia. Perm J. 2012;16(2):57.","DOI":"10.7812\/TPP\/12-015"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Kantor ED, Rehm CD, Haas JS, et al. Trends in prescription drug use among adults in the United States from 1999-2012. JAMA. 2015;314(17):1818-30.","DOI":"10.1001\/jama.2015.13766"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Tannen RL. Diuretic-induced hypokalemia. Kidney Int. 1985;28(6):988-1000.","DOI":"10.1038\/ki.1985.229"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Cohen T. Hypokalemic muscle paralysis associated with administration of chlorothiazide. JAMA. 1959;170(17):2083-5.","DOI":"10.1001\/jama.1959.63010170003010a"},{"key":"ref4","unstructured":"Veltri KT and Mason C. Medication-induced hypokalemia. PT. 2015;40(3):185-90."},{"key":"ref5","unstructured":"Marti G, Schwarz C, Leichtle AB, et al. Etiology and symptoms of severe hypokalemia in emergency department patients. Eur J Emerg Med. 2014;21(1):46-51."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Moses E and Rigas K. Metabolic abnormalities in alcoholic patients: focus on acid base and electrolyte disorders. J Alcohol Drug Depend. 2015;2(185):2.","DOI":"10.4172\/2329-6488.1000185"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Lee TW, Bae E, Hwang K, et al. Severe hypokalemic paralysis and rhabdomyolysis occurring after binge eating in a young bodybuilder: Case report. Medicine (Baltimore). 2017;96(40):e8251.","DOI":"10.1097\/md.0000000000008478"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Sung CC, Cheng CJ, Chiang WF, et al. Etiologic and therapeutic analysis in patients with hypokalemic nonperiodic paralysis. Am J Med. 2015;128(3):289-96.","DOI":"10.1016\/j.amjmed.2014.09.027"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Levitt JO. Practical aspects in the management of hypokalemic periodic paralysis. J Transl Med. 2008;6(1):18.","DOI":"10.1186\/1479-5876-6-18"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Cohn JN, Kowey PR, Whelton PK, et al. New guidelines for potassium replacement in clinical practice: a contemporary review by the National Council on Potassium in Clinical Practice. Arch Intern Med. 2000;160(16):2429-36.","DOI":"10.1001\/archinte.160.16.2429"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Hamill-Ruth RJ and McGory R. Magnesium repletion and its effect on potassium homeostasis in critically ill adults: results of a double-blind, randomized, controlled trial. Crit Care Med. 1996;24(1):38-45.","DOI":"10.1097\/00003246-199601000-00009"}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T22:18:41Z","timestamp":1583792321000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/8ns2c3xj"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,20]]},"references-count":12,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,7,30]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2019.3.42062","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"type":"electronic","value":"2474-252X"},{"type":"print","value":"2474-252X"}],"subject":[],"published":{"date-parts":[[2019,5,20]]}}}