{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:42:57Z","timestamp":1726504977661},"reference-count":19,"publisher":"California Digital Library (CDL)","issue":"4","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>A 47-year-old schizophrenic male presented on three separate occasions with pancytopenia and sideroblastic anemia due to copper deficiency from massive zinc penny ingestion. The poisoning was treated differently on each visit: intravenous (IV) copper plus surgical decontamination and chelation with calcium disodium versenate (CaNa2EDTA); IV copper plus whole bowel irrigation; and IV copper with surgical decontamination only. Serum zinc half-lives were 80.0 hours, 233.2 hours, and 83.9 hours, respectively. Importantly, chelation with CaNa2EDTA did not significantly alter the elimination half-life. This is the first reported case of the same patient being treated on three different occasions with three different regimens for this condition.<\/jats:p>","DOI":"10.5811\/cpcem.2019.7.43697","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T17:53:07Z","timestamp":1572976387000},"page":"341-344","source":"Crossref","is-referenced-by-count":1,"title":["Pennies for Your Thoughts: A Case Series of Pancytopenia Due to Zinc-induced Copper Deficiency in the Same Patient"],"prefix":"10.5811","volume":"3","author":[{"given":"Bram","family":"Dolcourt","sequence":"first","affiliation":[{"name":"Wayne State University, Department of Emergency Medicine, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Paxton","sequence":"additional","affiliation":[{"name":"Wayne State University, Department of Emergency Medicine, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keenan","family":"Bora","sequence":"additional","affiliation":[{"name":"Wayne State University, Department of Emergency Medicine, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Aaron","sequence":"additional","affiliation":[{"name":"Wayne State University, Department of Emergency Medicine, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"ref0","unstructured":"US Department of Treasury. 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Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination. Am J Clin Pathol. 2005;123:125-31.","DOI":"10.1309\/v6gvyw2qtyd5c5pj"},{"key":"ref14","unstructured":"Doherty K, Connor M, Cruickshank R, et al. Massive penny ingestion: the loot with local and systemic effects. Am J Forensic Med Pathol. 2008;35:148-53."},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Doherty K, Connor M, Cruickshank R. Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy. Br Dent J. 2011;210:523-5.","DOI":"10.1038\/sj.bdj.2011.428"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Lazarchick J. Update on anemia and neutropenia in copper deficiency. Curr Opin Hematol. 2012;19:58-60.","DOI":"10.1097\/MOH.0b013e32834da9d2"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Peled T, Glukhman E, Hasson N, et al. Chelatable cellular copper modulates differentiation and self-renewal of cord blood-derived hematopoietic progenitor cells. Exp Hemato. 2005;33:1092-1100.","DOI":"10.1016\/j.exphem.2005.06.015"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Afrin LB. Fatal copper deficiency from excessive use of zinc-based denture adhesive. 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