{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:53:00Z","timestamp":1762005180383},"reference-count":14,"publisher":"California Digital Library (CDL)","issue":"1","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Recent epidemiologic data demonstrate increasing rates of neurosyphilis, particularly among those in the community of men who have sex with men and those coinfected with the human immunodeficiency virus (HIV). Here we discuss a case of early neurosyphilis and new HIV diagnosis in a 27-year-old previously-healthy trans woman presenting for the second time with progressive, ascending weakness and cranial nerve VI palsy. Emergency physicians should consider this rare but highly morbid diagnosis, given the rising prevalence of neurosyphilis among at-risk patients and those with new neurologic deficits.<\/jats:p>","DOI":"10.5811\/cpcem.2019.9.43871","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T07:26:23Z","timestamp":1581060383000},"page":"46-50","source":"Crossref","is-referenced-by-count":6,"title":["Neurosyphilis: Old Disease, New Implications for Emergency Physicians"],"prefix":"10.5811","volume":"4","author":[{"given":"Laura","family":"Mercurio","sequence":"first","affiliation":[{"name":"Alpert Medical School of Brown University, Department of Emergency Medicine, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of Rhode Island Providence Campus, CODAC Behavioral Health, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Jarman","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University, Department of Pediatrics, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"ref0","unstructured":"Centers for Disease Control and Prevention. Syphilis. 2017. Available at: https:\/\/www.cdc.gov\/std\/syphilis\/stats.htm. Accessed March 16, 2017."},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Zetola NM and Klausner JD. Syphilis and HIV infection: an update. Clin Infect Dis. 2007;44(9):1222-8.","DOI":"10.1086\/513427"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Chesson HW, Heffelfinger JD, Voigt RF, et al. Estimates of primary and secondary syphilis rates in persons with HIV in the United States, 2002. Sex Transm Dis. 2005;32(5):265-9.","DOI":"10.1097\/01.olq.0000162359.75509.9c"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Marra CM. Neurosyphilis. Continuum (Minneap Minn). 2015;21(6 Neuroinfectious Disease):1714-28.","DOI":"10.1212\/CON.0000000000000250"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Solomon MM and Mayer KH. Evolution of the syphilis epidemic among men who have sex with men. Sex Health. 2015;12(2):96-102.","DOI":"10.1071\/sh14173"},{"key":"ref5","unstructured":"Pialoux G, Vimont S, Moulignier A, et al. Effect of HIV infection on the course of syphilis. AIDS Rev. 2008;10(2):85-92."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Taylor MM, Aynalem G, Olea LM, et al. A consequence of the syphilis epidemic among men who have sex with men (MSM): neurosyphilis in Los Angeles, 2001-2004. Sex Transm Dis. 2008;35(5):430-4.","DOI":"10.1097\/olq.0b013e3181644b5e"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Chrzaszcz-Wlodarczyk A, Wlodarczyk A, Szarmach J. Diverse clinical presentations of neurosyphilis: focus on differential diagnosis. Neurol Sci. 2018;39(4):803-4.","DOI":"10.1007\/s10072-017-3204-2"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Marks M, Jarvis JN, Howlett W, et al. Neurosyphilis in Africa: a systematic review. PLoS Negl Trop Dis. 2017;11(8):e0005880.","DOI":"10.1371\/journal.pntd.0005880"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Chang CC, Leslie DE, Spelman D, et al. Symptomatic and asymptomatic early neurosyphilis in HIV-infected men who have sex with men: a retrospective case series from 2000 to 2007. Sex Health. 2011;8(2):207-13.","DOI":"10.1071\/sh10060"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Young H. Guidelines for serological testing for syphilis. Sex Transm Infect. 2000;76(5):403-5.","DOI":"10.1136\/sti.76.5.403"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Peng J, Lu Y, Yu H, et al. Analysis of 2 Reverse syphilis testing algorithms in diagnosis of syphilis: a large-cohort prospective study. Clin Infect Dis. 2018;67(6):947-53.","DOI":"10.1093\/cid\/ciy198"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"de Voux A, Bernstein K, Bradley H, et al. Syphilis testing among sexually active men who have sex with men and who are receiving medical care for HIV in the United States-Medical Monitoring Project, 2013-2014. Clin Infect Dis. 2019;68(6):934-9.","DOI":"10.1093\/cid\/ciy571"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Centers for Disease Control and Prevention. Symptomatic early neurosyphilis among HIV-positive men who have sex with men --- four cities, United States, January 2002--June 2004. MMWR Morb Mortal Wkly Rep. 2007;56(25):625-8.","DOI":"10.1037\/e639302007-001"}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T22:23:47Z","timestamp":1583792627000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/0gp0n4x6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,19]]},"references-count":14,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,2,3]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2019.9.43871","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"type":"electronic","value":"2474-252X"},{"type":"print","value":"2474-252X"}],"subject":[],"published":{"date-parts":[[2019,11,19]]}}}