{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T21:32:31Z","timestamp":1750109551972},"reference-count":15,"publisher":"California Digital Library (CDL)","issue":"2","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Portal venous thrombosis is a life-threatening cause of abdominal pain. In younger patients, heritable thrombophilias, pregnancy, tobacco use, and oral contraceptives are associated.\n\nCase Report: A 26-year-old woman prescribed contraceptive vaginal ring presented with abdominal pain and was diagnosed with an extensive portal venous thrombosis. Management included heparin and later an oral anticoagulant with good short-term outcome.\n\nDiscussion: Women using hormonal contraception are approximately four times more likely to develop thromboembolism. Risk of thromboembolism is similar between users of intravaginal and oral contraceptives.\n\nConclusion: Portal venous thrombosis must be considered in women presenting with abdominal pain who are prescribed hormonal contraceptives, including intravaginal forms.<\/jats:p>","DOI":"10.5811\/cpcem.2020.1.44654","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T22:23:53Z","timestamp":1588717433000},"page":"263-266","source":"Crossref","is-referenced-by-count":6,"title":["Portal Venous Thrombosis Associated with Use of Etonogestrel\/ethinyl Estradiol Vaginal Ring"],"prefix":"10.5811","volume":"4","author":[{"given":"Katelynn","family":"Bailey","sequence":"first","affiliation":[{"name":"Charleston Area Medical Center, Department of Emergency Medicine, Charleston, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tranovich","sequence":"additional","affiliation":[{"name":"Allegheny Health Network, Department of Emergency Medicine, Canonsburg, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Meltzer AC, Pines JM, Richards LM, et al. US emergency department visits for adults with abdominal and pelvic pain (2007-13): Trends in demographics, resource utilization and medication usage. Am J Emerg Med. 2017;35(12):1966-9.","DOI":"10.1016\/j.ajem.2017.06.019"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Harnik IG and Brandt LJ. Mesenteric venous thrombosis. Vasc Med. 2010;15(5):407-18.","DOI":"10.1177\/1358863X10379673"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Russell CE, Wadhera RK, Piazza G. Mesenteric venous thrombosis. Circulation. 2015;131(18):1599-603.","DOI":"10.1161\/circulationaha.114.012871"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Acosta S, Alhadad A, Svensson P, et al. Epidemiology, risk and prognostic factors in mesenteric venous thrombosis. Br J Surg. 2008;95(10):1245-51.","DOI":"10.1002\/bjs.6319"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Hmoud B, Singal AK, Kamath PS. Mesenteric venous thrombosis. J Clin Exp Hepatol. 2014;4(3):257-63.","DOI":"10.1016\/j.jceh.2014.03.052"},{"key":"ref5","unstructured":"Grant PJ, Courey AJ, Hanigan S, et al. Special topics in venous thromboembolism [Internet]. Ann Arbor (MI): Michigan Medicine University of Michigan. 2019. Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544377\/. Accessed July 28, 2019."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Condat B, Pessione F, Denninger MH, et al. Recent portal or mesenteric venous thrombosis: increased recognition and frequent recanalization on anticoagulant therapy. Clin Liver Dis. 2003;32(3):466-70.","DOI":"10.1053\/jhep.2000.16597"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Intagliata NM, Caldwell SH, Tripodi A. Diagnosis, development, and treatment of portal vein thrombosis in patients with and without cirrhosis. Gastroenterology. 2019;156(6):1582-99.","DOI":"10.1053\/j.gastro.2019.01.265"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016;149(2):315-52.","DOI":"10.1016\/j.chest.2016.08.1442"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Sitruk-Ware R. Hormonal contraception and thrombosis. Fertil Steril. 2016;106(6):1289-94.","DOI":"10.1016\/j.fertnstert.2016.08.039"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Klok FA and Barco S. Optimal management of hormonal contraceptives after an episode of venous thromboembolism. Thromb Res. 2019;181 Suppl 1:S1-S5.Tc.","DOI":"10.1016\/s0049-3848(19)30357-3"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Tchaikovski SN and Rosing J. Mechanisms of estrogen-induced venous thromboembolism. Thromb Res. 2010;126(1):5-11.","DOI":"10.1016\/j.thromres.2010.01.045"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Dinger J, Mohner S, Heinemann K. Cardiovascular risk associated with the use of an etonogestrel-containing vaginal ring. Obstet Gynecol. 2013;122(4):800-8.","DOI":"10.1097\/aog.0b013e3182a5ec6b"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Eilbert W, Hecht B, Zuiderveld L. Acute mesenteric venous thrombosis with a vaginal contraceptive ring. West J Emerg Med. 2014;15(4):395-7.","DOI":"10.5811\/westjem.2014.4.21364"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Voora D and Vijayan A. Mesenteric vein thrombosis associated with intravaginal contraceptives: a case report and review of the literature. J Thromb Thrombolysis. 2003;15(2):105-8.","DOI":"10.1023\/b:thro.0000003323.80742.4d"}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T20:41:19Z","timestamp":1595277679000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/3qk5d0hp"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":15,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2020.1.44654","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"type":"electronic","value":"2474-252X"},{"type":"print","value":"2474-252X"}],"subject":[],"published":{"date-parts":[[2020,4,14]]}}}