{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:58:54Z","timestamp":1762001934769},"reference-count":17,"publisher":"California Digital Library (CDL)","issue":"3","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background: Acute cholecystitis is the acute inflammation of the gallbladder. In adults it is most frequently caused by a gallstone(s) obstructing outflow from the cystic duct, leading to gallbladder distention and edema with eventual development of biliary stasis and bacterial overgrowth, often requiring operative management. However, in children acalculous cholecystitis is more common and is often the result of an infectious process. \n\nCase Report: Here we present a case of acute acalculous cholecystitis caused by infection with Epstein-Barr virus in an otherwise healthy three-year-old male.\n\nConclusion: Acalculous cholecystitis is an uncommon but potentially significant complication of Epstein-Barr virus infection in the pediatric population. Emergency providers should consider this diagnosis in any child being evaluated for EBV with the complaint of abdominal pain.<\/jats:p>","DOI":"10.5811\/cpcem.2020.4.46301","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T19:31:34Z","timestamp":1597260694000},"page":"393-396","source":"Crossref","is-referenced-by-count":6,"title":["Acute Acalculous Cholecystitis from Infection with Epstein\u2013Barr Virus in a Previously Healthy Child: A Case Report"],"prefix":"10.5811","volume":"4","author":[{"given":"Robert","family":"Langenohl","sequence":"first","affiliation":[{"name":"Madigan Army Medical Center, Department of Emergency Medicine, Tacoma, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Young","sequence":"additional","affiliation":[{"name":"Madigan Army Medical Center, Department of Emergency Medicine, Tacoma, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Couperus","sequence":"additional","affiliation":[{"name":"Madigan Army Medical Center, Department of Emergency Medicine, Tacoma, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"ref0","unstructured":"Neville HL. 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Pediatr Neonatol. 2017;58(6):497-503.","DOI":"10.1016\/j.pedneo.2016.12.005"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Huffman JL and Schenker S. Acute acalculous cholecystitis: a review. Clin Gastroenterol Hepatol. 2010;8(1):15-22.","DOI":"10.1016\/j.cgh.2009.08.034"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Yi DY, Kim JY, Yang HR. Ultrasonographic gallbladder abnormality of primary Epstein\u2013Barr virus infection in children and its influence on clinical outcome. Medicine. 2015;94(27).","DOI":"10.1097\/md.0000000000001120"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Owen C and Jain R. Acute acalculous cholecystitis. Curr Treat Options Gastroenterol. 2005;8(2):99-104.","DOI":"10.1007\/s11938-005-0001-4"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Yasuda H, Takada T, Kawarada Y, et al. Unusual cases of acute cholecystitis and cholangitis: Tokyo Guidelines. Ann Hepatobilliary Pancreat Surg. 2007;14(1):98-113.","DOI":"10.1007\/s00534-006-1162-9"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Kottanattu L, Lava SA, Helbling R, et al. Pancreatitis and cholecystitis in primary acute symptomatic Epstein-Barr virus infection: systematic review of the literature. J Clin Virol. 2016;82:51-5.","DOI":"10.1016\/j.jcv.2016.06.017"}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:12:01Z","timestamp":1600283521000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/3qj0687m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":17,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,8,6]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2020.4.46301","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"type":"electronic","value":"2474-252X"},{"type":"print","value":"2474-252X"}],"subject":[],"published":{"date-parts":[[2020,6,15]]}}}