{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:44:55Z","timestamp":1726505095069},"reference-count":8,"publisher":"California Digital Library (CDL)","issue":"3","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background: Nicotiana glauca is a plant known to cause acute toxicity upon ingestion or dermal exposure due to the nicotinic alkaloid, anabasine. Nicotinic alkaloids cause toxicity by acting as agonists on nicotinic-type acetylcholine receptors (nAChRs). Initial stimulation of these receptors leads to symptoms such as tachycardia, miosis, and tremors. The effects of high doses of nicotinic alkaloids are biphasic, and eventual persistent depolarization of nAChRs at the neuromuscular junction occurs. This causes apnea, paralysis, and cardiovascular collapse. \n\nCase Report: In this report, we present a case of respiratory arrest due to nicotinic alkaloid poisoning from the ingestion of Nicotiana glauca. The diagnosis was suspected after the patient\u2019s family gave a history of the patient ingesting a plant prior to arrival. They were able to also provide a physical sample of the plant. \n\nConclusion: The phone application, \u201cPlant Snap\u201d, determined the plant species and helped confirm the diagnosis. This case describes how modern technology and thorough history taking can combine to provide the best possible patient care.<\/jats:p>","DOI":"10.5811\/cpcem.2020.5.46703","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T19:31:14Z","timestamp":1597260674000},"page":"371-374","source":"Crossref","is-referenced-by-count":1,"title":["Ingestion of A Common Plant\u2019s Leaves Leads to Acute Respiratory Arrest and Paralysis: A Case Report"],"prefix":"10.5811","volume":"4","author":[{"given":"Breelan","family":"Kear","sequence":"first","affiliation":[{"name":"University of California, Irvine Medical Center, Department of Emergency Medicine, Orange, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Lee","sequence":"additional","affiliation":[{"name":"University of California, Irvine Medical Center, Department of Internal Medicine, Orange, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanford","family":"Church","sequence":"additional","affiliation":[{"name":"University of California, Irvine Medical Center, Department of Internal Medicine, Orange, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fady","family":"Youssef","sequence":"additional","affiliation":[{"name":"Memorial Care, Long Beach Medical Center, Department of Pulmonary and Critical Care Medicine, Long Beach, California; University of California, Irvine Medical Center, Department of Pulmonary and Critical Care Medicine, Orange, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Arguija","sequence":"additional","affiliation":[{"name":"Memorial Care, Long Beach Medical Center, Department of Emergency Medicine, Long Beach, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Schep L, Slaughter R, Beasley D. Nicotinic plant poisoning.\u00a0Clin Toxicol. 2009;47(8):771-81.","DOI":"10.1080\/15563650903252186"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Furer V, Hersch M, Silvetzki N, et al. Nicotiana glauca (tree tobacco) intoxication-two cases in one family.\u00a0J Med Toxicol.  2010;7(1):47-51.","DOI":"10.1007\/s13181-010-0102-x"},{"key":"ref2","unstructured":"Invasive Plant Atlas of the United States. Tree tobacco: Nicotiana glauca Graham. 2018. Available at https:\/\/www.invasiveplantatlas.org\/subject.html?sub=6083. Accessed August 7, 2019."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Manoguerra A and Freeman D. Acute poisoning from the ingestion of Nicotiana glauca.\u00a0J Toxicol Clin Toxicol. 1982;19(8):861-4.","DOI":"10.3109\/15563658208992520"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Murphy N, Albin C, Tai W, et al. Anabasine toxicity from a topical folk remedy.\u00a0Clin Pediatr. 2006;45(7):669-71.","DOI":"10.1177\/0009922806291022"},{"key":"ref5","unstructured":"PlantSnap. Who We Are. 2019. Available at: http:\/\/www.plantsnap.com\/who-we-are. Accessed January 24, 2020."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Sercan Y and Selahattin K. Respiratory failure due to plant poisoning: Nicotiana glauca Graham.\u00a0J Emerg Med. 2018;55(3):e61-3.","DOI":"10.1016\/j.jemermed.2018.06.039"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Steenkamp PA, Van heerden FR, Van wyk BE. Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography\/photodiode array\/mass spectrometry. Forensic Sci Int. 2002;127(3):208-17.","DOI":"10.1016\/s0379-0738(02)00123-8"}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:10:13Z","timestamp":1600283413000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/1vm1t2vv"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,9]]},"references-count":8,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,8,6]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2020.5.46703","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"type":"electronic","value":"2474-252X"},{"type":"print","value":"2474-252X"}],"subject":[],"published":{"date-parts":[[2020,7,9]]}}}