{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:10:52Z","timestamp":1770487852288,"version":"3.49.0"},"reference-count":12,"publisher":"California Digital Library (CDL)","issue":"3","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Respiratory viral illnesses are associated with diverse neurological complications, including acute transverse myelitis (ATM). Among the respiratory viral pathogens, the Coronaviridae family and its genera coronaviruses have been implicated as having neurotropic and neuroinvasive capabilities in human hosts.1 Despite previous strains of coronaviruses exhibiting neurotropic and neuroinvasive capabilities, little is known about the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its involvement with the central nervous system (CNS). The current pandemic has highlighted the diverse clinical presentation of SARS-CoV-2 including a possible link to CNS manifestation with disease processes such as Guillain-Barr\u00e9 syndrome and cerebrovascular disease. It is critical to shed light on the varied neurological manifestation of SARS-CoV-2 to ensure clinicians do not overlook at-risk patient populations and are able to provide targeted therapies appropriately. \n\nCase Report: While there are currently no published reports on post-infectious ATM secondary to SARS-CoV-2, there is one report of parainfectious ATM attributed to SARS-CoV-2 in pre-print. Here, we present a case of infectious ATM attributed to SARS-CoV-2 in a 24-year-old male who presented with bilateral lower-extremity weakness and overflow urinary incontinence after confirmed SARS-CoV-2 infection. Magnetic resonance imaging revealed non-enhancing T2-weighted hyperintense signal abnormalities spanning from the seventh through the twelfth thoracic level consistent with acute myelitis. \n\nConclusion: The patient underwent further workup and treatment with intravenous corticosteroids with improvement of symptoms and a discharge diagnosis of ATM secondary to SARS-CoV-2.<\/jats:p>","DOI":"10.5811\/cpcem.2020.6.48462","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T04:15:28Z","timestamp":1597205728000},"page":"344-348","source":"Crossref","is-referenced-by-count":21,"title":["Acute Transverse Myelitis Secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Case Report"],"prefix":"10.5811","volume":"4","author":[{"given":"Muhammad","family":"Durrani","sequence":"first","affiliation":[{"name":"Inspira Medical Center, Department of Emergency Medicine, Vineland, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Kucharski","sequence":"additional","affiliation":[{"name":"Inspira Medical Center, Department of Emergency Medicine, Vineland, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Smith","sequence":"additional","affiliation":[{"name":"Inspira Medical Center, Department of Emergency Medicine, Vineland, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Fien","sequence":"additional","affiliation":[{"name":"Inspira Medical Center, Department of Emergency Medicine, Vineland, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Bohmwald K, G\u00e1lvez NMS, R\u00edos M, et al. Neurologic alterations due to respiratory virus infections. Front Cell Neurosci. 2018;12:386.","DOI":"10.3389\/fncel.2018.00386"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Altrocchi PH. Acute transverse myelopathy. Trans Am Neurol Assoc. 1963;88:186-8.","DOI":"10.1001\/archneur.1963.00460080021002"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Misra UK, Kalita J, Kumar S. A Clinical, MRI and neurophysiological study of acute transverse myelitis. J Neurol Sci. 1996;138(1-2):150-6.","DOI":"10.1016\/0022-510x(95)00353-4"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Klein N, Ray P, Carpenter D, et al. Rates of autoimmune diseases in Kaiser Permanente for use in vaccine adverse event safety studies. Vaccine. 2010;28(4):1062-8.","DOI":"10.1016\/j.vaccine.2009.10.115"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Borchers AT and Gershwin ME. Transverse myelitis. Autoimmun Rev. 2012;11(3):231-48.","DOI":"10.1016\/j.autrev.2011.05.018"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Transverse Myelitis Consortium Working Group. Proposed diagnostic criteria and nosology of acute transverse myelitis. Neurology. 2002;59(4):499-505.","DOI":"10.1212\/wnl.59.4.499"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Turgay C, Emine T, Ozlem K, et al. A rare cause of acute flaccid paralysis: human coronaviruses. J Pediatr Neurosci. 2015;10(3):280-1.","DOI":"10.4103\/1817-1745.165716"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"St-Jean JR, Jacomy H, Desforges M, et al. Human respiratory coronavirus OC43: genetic stability and neuroinvasion. J Virol. 2004;78(16):8824-34.","DOI":"10.1128\/jvi.78.16.8824-8834.2004"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Paniz-Mondolfi A, Bryce C, Grimes Z, et al. Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). J Med Virol. 2020;92(7):699-702.","DOI":"10.1002\/jmv.25915"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Desforges M, Le Coupanec A, Dubeau P, et al. Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses. 2019;12(1):14.","DOI":"10.3390\/v12010014"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Herman C, Mayer K, Sarwal A. [Ahead of Print]. Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19. Neurology. April 28, 2020.","DOI":"10.1212\/wnl.0000000000009673"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Zhao K, Huang J, Dai D, et al. Acute myelitis after SARS-CoV-2 infection: a case report. medRxiv. 2020. Available at: https:\/\/www.medrxiv.org\/content\/10.1101\/2020.03.16.20035105v1.full.pdf. Accessed May 15, 2020.","DOI":"10.1101\/2020.03.16.20035105"}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:05:09Z","timestamp":1600283109000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/2fs6w4c3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":12,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,8,6]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2020.6.48462","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"value":"2474-252X","type":"electronic"},{"value":"2474-252X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,22]]}}}