{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:44:45Z","timestamp":1726505085212},"reference-count":10,"publisher":"California Digital Library (CDL)","issue":"4","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: The literature on the clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) suggests patients continue shedding viral particles typically for an average of 20 days until the body builds immunity against the infection. However, a few cases have shown prolonged duration in viral shedding and highlight the significant increased mortality in these patients. It has also been suggested that multiple strains of SARS-COV-2 exist, keying the possibility to reinfection. \n\nCase Report: We present a case of a 57-year-old male who presented twice over 37 days with symptoms related to SARS-COV-2, and only on his second visit was found to be in hypoxemic respiratory failure and cardiogenic shock. He also reportedly had a period of convalescence in between presentations. \n\nDiscussion: This case highlights the still unclear disease course of SARS-COV-2 and the need for diligence in providing strong follow-up instructions and evaluation for sequelae of the infection.<\/jats:p>","DOI":"10.5811\/cpcem.2020.7.49005","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T18:28:57Z","timestamp":1605637737000},"page":"509-512","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged Duration of Viral Shedding of SARS-CoV-2: A Case Report"],"prefix":"10.5811","volume":"4","author":[{"given":"Brandon","family":"Fong","sequence":"first","affiliation":[{"name":"Thomas Jefferson University Hospital, Department of Emergency Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kory","family":"London","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University Hospital, Department of Emergency Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Li X and Ma X. Acute respiratory failure in COVID-19: is it \u201ctypical\u201d ARDS? Crit Care. 2020;24(1):198.","DOI":"10.1186\/s13054-020-02911-9"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Zhou B, She J, Wang Y, et al. The duration of viral shedding of discharged patients with severe COVID-19. Clin Infect Dis. 2020. In press.","DOI":"10.1093\/cid\/ciaa451"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Lazaridis C, Vlachogiannis NI, Bakogiannis C, et al. Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery. Hellenic J Cardiol. 2020. In press.","DOI":"10.1016\/j.hjc.2020.05.004"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Barnes GD, Burnett A, Allen A, et al. Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum. Journal Thromb Thrombolys. 2020;50:72-81.","DOI":"10.1007\/s11239-020-02138-z"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Li XJ, Zhang ZW, Zong ZY. A case of a readmitted patient who recovered from COVID-19 in Chengdu, China. Critic Care. 2020;24(1):152.","DOI":"10.1186\/s13054-020-02877-8"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Liu Y, Chen X, Zou X, et al. A severe-type COVID-19 case with prolonged virus shedding. J Formos Med Assoc. 2020. In press.","DOI":"10.1016\/j.jfma.2020.05.004"},{"key":"ref6","unstructured":"Robbiani DF, Gaebler C, Muecksch F, et al. Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature. 2020. In press."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Pachetti M, Marini B, Benedetti F, et al. Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. J Transl Med. 2020;18(1):179.","DOI":"10.1186\/s12967-020-02344-6"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Xu K, Chen Y, Yuan J, et al. Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clin Infect Dis. 2020;71(15):799-806.","DOI":"10.1093\/cid\/ciaa351"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Bonow RO, Fonarow GC, O\u2019Gara PT, et al. Association of coronavirus disease 2019 (COVID-19) with myocardial injury and mortality. JAMA Cardiol. 2020. In press.","DOI":"10.1001\/jamacardio.2020.1105"}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T21:00:46Z","timestamp":1605819646000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/2wx2r63w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,8]]},"references-count":10,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,11,10]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2020.7.49005","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"type":"electronic","value":"2474-252X"},{"type":"print","value":"2474-252X"}],"subject":[],"published":{"date-parts":[[2020,8,8]]}}}