{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:39:40Z","timestamp":1761061180984},"reference-count":7,"publisher":"California Digital Library (CDL)","issue":"4","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Coronavirus disease 2019 (COVID-19) has spread around the world and caused hundreds of thousands of fatalities across a wide spectrum of patients with varying severity and presenting complaints. The discussion of the ability of this disease to cause significant illness in patients with various risk factors such as myasthenia gravis is important to help guide physicians on recognition and treatment options as the pandemic matures. \n\nCase Report: Here we discuss a single case of isolated COVID-19 infection that precipitated a myasthenic crisis with no other clinical sequelae in a patient who presented to the emergency department (ED). This report highlights some of the initial difficulties and delay in diagnosis encountered earlier in the pandemic with limited testing supplies and processing labs; however, prompt ED recognition and treatment still led to a favorable outcome. \n\nConclusion: The patient recovered during this initial presentation and was successfully treated with plasma exchange and steroids only. It is important to recognize that myasthenia gravis patients may represent a uniquely vulnerable population that requires enhanced surveillance and screening to prevent significant morbidity and mortality. This case describes how even a mild infection with no significant clinical sequelae or significant signs on imaging studied can precipitate a crisis event.<\/jats:p>","DOI":"10.5811\/cpcem.2020.9.49049","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T13:29:39Z","timestamp":1605619779000},"page":"524-526","source":"Crossref","is-referenced-by-count":9,"title":["Isolated COVID-19 Infection Precipitates Myasthenia Gravis Crisis: A Case Report"],"prefix":"10.5811","volume":"4","author":[{"given":"Phillip","family":"Moschella","sequence":"first","affiliation":[{"name":"University of South Carolina School of Medicine Greenville, Prisma Health: Upstate Affiliate, Department of Emergency Medicine, Greenville, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prerana","family":"Roth","sequence":"additional","affiliation":[{"name":"University of South Carolina School of Medicine Greenville, Prisma Health: Upstate Affiliate, Department of Infectious Disease, Greenville, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Banerjee A, Kulcsar K, Misra V, et al. Bats and coronaviruses. Viruses. 2019;11(1):41.","DOI":"10.3390\/v11010041"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Zhang L and Liu Y. Potential interventions for novel coronavirus in China: a systematic review. J Med Virol. 2020;92(5):479-90.","DOI":"10.1002\/jmv.25707"},{"key":"ref2","unstructured":"COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). Available at: https:\/\/coronavirus.jhu.edu\/map.html. Accessed on July 6, 2020."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Singh S and Govindarajan R. Covid-19 and generalized myasthenia gravis exacerbation: a case report. Clin Neurol Neurosurg. 2020;196:106045.","DOI":"10.1016\/j.clineuro.2020.106045"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Anand P, Slama MC, Kaku M, et al. COVID-19 in patients with myasthenia gravis. Muscle Nerve. 2020;62(2):254-8.","DOI":"10.1002\/mus.26918"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Cozzi D, Albanesi M, Cavigli E, et al. Chest X-ray in new coronavirus disease 2019 (COVID-19) infection: findings and correlation with clinical outcome. Radiol Med. 2020;125(8):730-7.","DOI":"10.1007\/s11547-020-01232-9"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Sanders D, Wolfe G, Benatar M, et al. International consensus guidance for management of myasthenia gravis: Executive summary. Neurology. 2016;87(4):419-25.","DOI":"10.1212\/wnl.0000000000002790"}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T16:02:38Z","timestamp":1605801758000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/2xd2t0xs"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,9]]},"references-count":7,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,11,10]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2020.9.49049","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"type":"electronic","value":"2474-252X"},{"type":"print","value":"2474-252X"}],"subject":[],"published":{"date-parts":[[2020,10,9]]}}}