{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:45:30Z","timestamp":1726505130941},"reference-count":10,"publisher":"California Digital Library (CDL)","issue":"5","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Local outbreaks of measles infection are primarily mediated by international travel of persons from endemic areas, with subsequent spread of the virus via undervaccinated populations. Recent resurgences of measles in communities where vaccination rates are non-ideal secondary to philosophical objections require the emergency physician to more routinely consider the diagnosis. In cases of measles complicated by acute encephalitis or encephalopathy, the diagnosis can be especially difficult to make due to lack of a reliable primary historian.  \n\nCase report: Here we present a case of altered mental status and new-onset bilateral lower extremity weakness in a fully vaccinated young woman diagnosed with measles infection caused by acute disseminated encephalomyelitis in the setting of vaccine failure. \n\nConclusion: Despite a documented history of immunization, acute measles infection and its uncommon sequelae are possible. Recognizing vaccine failure and appropriately isolating patients are of paramount importance.<\/jats:p>","DOI":"10.5811\/cpcem.2021.2.49481","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T01:14:22Z","timestamp":1621559662000},"page":"171-173","source":"Crossref","is-referenced-by-count":2,"title":["Acute Demyelinating Encephalomyelitis Following Measles Infection Due to Vaccine Failure: A Case Report"],"prefix":"10.5811","volume":"2","author":[{"given":"Robert","family":"McMickle","sequence":"first","affiliation":[{"name":"Harbor-UCLA Medical Center, Department of Emergency Medicine, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Fryling","sequence":"additional","affiliation":[{"name":"Harbor-UCLA Medical Center, Department of Emergency Medicine, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Fleischman","sequence":"additional","affiliation":[{"name":"Harbor-UCLA Medical Center, Department of Emergency Medicine, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"McLean HQ, Fiebelkorn AP, Temte JL, et al. Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013: summary recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2013;62(RR-04):1-34. Erratum in: MMWR Recomm Rep. 2015;64(9):259.","DOI":"10.1037\/e547712006-001"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"O\u2019donnell S, Davies F, Vardhan M, et al. Could this be measles? Emerg Med J. 2019;36(5):310-4.","DOI":"10.1136\/emermed-2019-208490"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"lves graber EM, Andrade FJ, Bost W, et al. An Update and review of measles for emergency physicians. J Emerg Med. 2020;58(4):610-5.","DOI":"10.1016\/j.jemermed.2020.02.007"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Moss WJ and Pollack FP. Immune responses to measles and measles vaccine: challenges for measles control.\u00a0Viral Immunol. 2001;14:297-309.","DOI":"10.1089\/08828240152716556"},{"key":"ref4","unstructured":"Weida JA. (2019). Measles (rubeola). In: Kellerman RD, and Rakel D (Eds.), Conn\u2019s Current Therapy (p. 580-582). Philadelphia, PA: Elsevier."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Pohl D, Alper G, Van Haren K, et al. Acute disseminated encephalomyelitis: updates on an inflammatory CNS syndrome. Neurology. 2016;87(9 Suppl 2):S38-45.","DOI":"10.1212\/wnl.0000000000002825"},{"key":"ref6","unstructured":"Centers for Disease Control and Prevention.\u00a0Healthcare Professionals: Clinical Resources. 2020. Available at: https:\/\/www.cdc.gov\/measles\/hcp\/index.html. Accessed November 24, 2020."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Paules CI, Marston HD, Fauci AS. Measles in 2019 - going backward. N Engl J Med. 2019;380(23):2185-7.","DOI":"10.1056\/nejmp1905099"},{"key":"ref8","unstructured":"Centers for Disease Control and Prevention. Healthcare Professionals: Clinical Resources. 2020. Available at: https:\/\/www.cdc.gov\/measles\/hcp\/index.html. Accessed November 24, 2020."},{"key":"ref9","unstructured":"Rumore MM. Vitamin A as an immunomodulating agent. Clin Pharm. 1993;12(7):506-14."}],"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"deposited":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T01:14:31Z","timestamp":1621559671000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/4nj8j8mk"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":10,"issue-title":["Clinical Practice and Cases in Emergency Medicine"],"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,18]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.2021.2.49481","relation":{},"ISSN":["2474-252X","2474-252X"],"issn-type":[{"type":"electronic","value":"2474-252X"},{"type":"print","value":"2474-252X"}],"subject":[],"published":{"date-parts":[[2021,3,24]]}}}