{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:48:38Z","timestamp":1778881718192,"version":"3.51.4"},"reference-count":0,"publisher":"California Digital Library (CDL)","issue":"4","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Practice and Cases in Emergency Medicine"],"abstract":"<p>Introduction: One of the less common and more life-threatening etiologies of adrenal insufficiency is immune checkpoint inhibitor (ICI)-induced primary adrenal insufficiency (PAI). Patients typically present with fatigue, malaise, and nausea and are treated empirically with hydrocortisone. Case Report: We present the case of a 59-year-old female who presented with hypotension, which initially was thought to be due to hypovolemia or medication-related, but was ultimately found to have PAI. Conclusion: This case highlights the importance of early detection of ICI-induced primary adrenal insufficiency, given its associated morbidity and mortality and its incidence in patients with a history of immunotherapy.<\/p>","DOI":"10.5811\/cpcem.20448","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T17:43:18Z","timestamp":1724694198000},"source":"Crossref","is-referenced-by-count":1,"title":["Immune Checkpoint Inhibitor-Induced Primary Adrenal Insufficiency: A Case Report"],"prefix":"10.5811","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-812X","authenticated-orcid":false,"given":"Rahul","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cary","family":"Lubkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29705","published-online":{"date-parts":[[2024,8,26]]},"container-title":["Clinical Practice and Cases in Emergency Medicine"],"original-title":[],"link":[{"URL":"https:\/\/escholarship.org\/content\/qt8nx589cr\/qt8nx589cr.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:54:36Z","timestamp":1732841676000},"score":1,"resource":{"primary":{"URL":"https:\/\/escholarship.org\/uc\/item\/8nx589cr"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,26]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,11,27]]}},"URL":"https:\/\/doi.org\/10.5811\/cpcem.20448","relation":{},"ISSN":["2474-252X"],"issn-type":[{"value":"2474-252X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,26]]}}}