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J Am Coll Cardiol. 2006;47(1):91-7.","DOI":"10.1016\/j.jacc.2005.08.051"},{"key":"ref81","doi-asserted-by":"publisher","unstructured":"Levitt JE, Vinayak AG, Gehlbach BK, et al. Diagnostic utility of B-type natriuretic peptide in critically ill patients with pulmonary edema: a prospective cohort study. Crit Care. 2008;12(1):R3.","DOI":"10.1186\/cc6764"},{"key":"ref82","doi-asserted-by":"publisher","unstructured":"Bajaj A, Rathor P, Sehgal V, et al. Prognostic value of biomarkers in acute non-massive pulmonary embolism: a systematic review and meta-analysis. Lung. 2015;193(5):639-51.","DOI":"10.1007\/s00408-015-9752-4"},{"key":"ref83","doi-asserted-by":"publisher","unstructured":"Coutance G, Cauderlier E, Ehtisham J, et al. The prognostic value of markers of right ventricular dysfunction in pulmonary embolism: a meta-analysis. Crit Care. 2011;15(2):R103.","DOI":"10.1186\/cc10119"},{"key":"ref84","doi-asserted-by":"publisher","unstructured":"Ruocco G, Cekorja B, Rottoli P, et al. Role of BNP and echo measurement for pulmonary hypertension recognition in patients with interstitial lung disease: an algorithm application model. Respir Med. 2015;109(3):406-15.","DOI":"10.1016\/j.rmed.2014.12.011"},{"key":"ref85","doi-asserted-by":"publisher","unstructured":"Bergler-Klein J, Gyongyosi M, Maurer G. The role of biomarkers in valvular heart disease: focus on natriuretic peptides. Can J Cardiol. 2014;30(9):1027-34.","DOI":"10.1016\/j.cjca.2014.07.014"},{"key":"ref86","doi-asserted-by":"publisher","unstructured":"Lam LL, Cameron PA, Schneider HG, et al. Meta-analysis: effect of B-type natriuretic peptide testing on clinical outcomes in patients with acute dyspnea in the emergency setting. Ann Intern Med. 2010;153(11):728-35.","DOI":"10.7326\/0003-4819-153-11-201012070-00006"},{"key":"ref87","doi-asserted-by":"publisher","unstructured":"Trinquart L, Ray P, Riou B, Teixeira A. Natriuretic peptide testing in EDs for managing acute dyspnea: a meta-analysis. 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J Am Coll Cardiol. 2004;44(6):1328\u201333.","DOI":"10.1016\/s0735-1097(04)90024-1"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Maisel AS, Krishnaswamy P, Nowak RM, et al.\u00a0Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.\u00a0N Engl J Med. 2002;347(3):161-7.\u00a0","DOI":"10.1056\/NEJMoa020233"},{"key":"ref90","doi-asserted-by":"publisher","unstructured":"McCullough PA, Nowak RM, McCord J.\u00a0B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study. 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Prognostic significance of ECG abnormalities for mortality risk in acute heart failure: insight from the Sub-Saharan Africa Survey of Heart Failure (THESUS-HF). J Card Fail. 2014;20(1):45-52.","DOI":"10.1016\/j.cardfail.2013.11.005"},{"key":"ref100","doi-asserted-by":"publisher","unstructured":"Knudsen CW, Omland T, Clopton P, et al. Diagnostic value of B-type natriuretic peptide and chest radiographic findings in patients with acute dyspnea. Am J Med. 2004;116(6):363-8.","DOI":"10.1016\/j.accreview.2004.04.025"},{"key":"ref101","doi-asserted-by":"publisher","unstructured":"V\u00e1clav\u00edk J, \u0160pinar J, Vindi\u0161 D, et al. ECG in patients with acute heart failure can predict in-hospital and long-term mortality. Intern Emerg Med. 2014;9(3):283-91.","DOI":"10.1007\/s11739-012-0862-1"},{"key":"ref102","doi-asserted-by":"publisher","unstructured":"Sartini S, Frizzi J, Borselli M, et al. Which method is best for an early accurate diagnosis of acute heart failure? Comparison between lung ultrasound, chest X-ray and NT pro-BNP performance: a prospective study. Intern Emerg Med. 2017;12(6):861\u20139.","DOI":"10.1007\/s11739-016-1498-3"},{"key":"ref103","doi-asserted-by":"crossref","unstructured":"Kennedy S, Simon B, Alter JH. Ability of physicians to diagnose congestive heart failure based on chest x-ray. J Emerg Med. 2011;40(1):47-52.","DOI":"10.1016\/j.jemermed.2009.10.018"},{"key":"ref104","doi-asserted-by":"publisher","unstructured":"Collins SP, Lindsell CJ, Storrow AB, Abraham WT; ADHERE Scientific Advisory Committee, Investigators and Study Group. Prevalence of negative chest radiography results in the emergency department patient with decompensated heart failure. Ann Emerg Med. 2006;47(1):13-8.","DOI":"10.1016\/j.annemergmed.2005.04.003"},{"key":"ref105","doi-asserted-by":"publisher","unstructured":"Volpicelli G, Melniker LA, Cardinale L, et al. Lung ultrasound in diagnosing and monitoring pulmonary interstitial fluid. Radiol Med. 2013;118(2):196-205.","DOI":"10.1007\/s11547-012-0852-4"},{"key":"ref106","doi-asserted-by":"publisher","unstructured":"Deeb MA, Barbic S, Featherstone R, et al. Point-of-care ultrasonography for the diagnosis of acute cardiogenic pulmonary edema in patients presenting with acute dyspnea: a systematic review and meta-analysis. Acad Emerg Med. 2014;21(8):844-52.","DOI":"10.1111\/acem.12435"},{"key":"ref107","doi-asserted-by":"crossref","unstructured":"Price S, Platz E, Cullen L, et al. Echocardiography and lung ultrasonography for the assessment and management of acute heart failure. Nature Reviews Cardiology. 2018;14(7):427-440.","DOI":"10.1038\/nrcardio.2017.56"},{"key":"ref108","doi-asserted-by":"publisher","unstructured":"Gargani L, Pang PS, Frassi F, et al. Persistent pulmonary congestion before discharge predicts rehospitalization in heart failure: a lung ultrasound study. Cardiovasc Ultrasound. 2015;13:40.","DOI":"10.1186\/s12947-015-0033-4"},{"key":"ref109","doi-asserted-by":"publisher","unstructured":"Jambrik Z, Monti S, Coppola V, et al. Usefulness of ultrasound lung comets as a nonradiologic sign of extravascular lung water. Am J Cardiol. 2004;93(10):1265-70","DOI":"10.1016\/j.amjcard.2004.02.012"},{"key":"ref110","doi-asserted-by":"publisher","unstructured":"Ahmadpour H, Shah AA, Allen JW, Edmiston WA, Kim SJ, Haywood LJ. Mitral E point septal separation: a reliable index of left ventricular performance in coronary artery disease. Am Heart J. 1983;106(1 Pt 1):21-8.","DOI":"10.1016\/0002-8703(83)90433-7"},{"key":"ref111","doi-asserted-by":"publisher","unstructured":"Secko MA, Lazar JM, Salciccioli LA, Stone MB. Can junior emergency physicians use E-point septal separation to accurately estimate left ventricular function in acutely dyspneic patients? Acad Emerg Med. 2011;18(11):1223-6.","DOI":"10.1111\/j.1553-2712.2011.01196.x"},{"key":"ref112","doi-asserted-by":"publisher","unstructured":"Silverstein JR, Laffely NH, Rifkin RD. Quantitative estimation of left ventricular ejection fraction from mitral valve E-point to septal separation and comparison to magnetic resonance imaging. Am J Cardiol. 2006;97(1):137-40.","DOI":"10.1016\/j.amjcard.2005.07.118"},{"key":"ref113","doi-asserted-by":"publisher","unstructured":"Anderson KL, Jenq KY, Fields JM, Panebianco NL, Dean AJ. Diagnosing heart failure among acutely dyspneic patients with cardiac, inferior vena cava, and lung ultrasonography. Am J Emerg Med. 2013;31(8):1208-14.","DOI":"10.1016\/j.ajem.2013.05.007"},{"key":"ref114","doi-asserted-by":"publisher","unstructured":"Gil Martinez P, Mesado Martinez D, Curbelo Garcia J, Cadinanos Loidi J. Amino-terminal pro-B-type natriuretic peptide, inferior vena cava ultrasound, and bioelectrical impedance analysis for the diagnosis of acute decompensated CHF. Am J Emerg Med. 2016;34(9):1817-22.","DOI":"10.1016\/j.ajem.2016.06.043"},{"key":"ref115","doi-asserted-by":"publisher","unstructured":"Kajimoto K, Madeen K, Nakayama T, Tsudo H, Kuroda T, Abe T. Rapid evaluation by lung-cardiac-inferior vena cava (LCI) integrated ultrasound for differentiating heart failure from pulmonary disease as the cause of acute dyspnea in the emergency setting. Cardiovasc Ultrasound. 2012;10(1):49.","DOI":"10.1186\/1476-7120-10-49"},{"key":"ref116","doi-asserted-by":"publisher","unstructured":"Miller JB, Sen A, Strote SR, et al. Inferior vena cava assessment in the bedside diagnosis of acute heart failure. Am J Emerg Med. 2012;30(5):778-83.","DOI":"10.1016\/j.ajem.2011.04.008"},{"key":"ref117","doi-asserted-by":"publisher","unstructured":"Russell FM, Ehrman RR, Cosby K, Ansari A, Tseeng S, Christian E, Bailitz J. Diagnosing acute heart failure in patients with undifferentiated dyspnea: a lung and cardiac ultrasound (LuCUS) protocol. Acad Emerg Med. 2015;22(2):182-91.","DOI":"10.1111\/acem.12570"},{"key":"ref118","doi-asserted-by":"publisher","unstructured":"Spinar J, Parenica J, Vitovec J, et al. Baseline characteristics and hospital mortality in the Acute Heart Failure Database (AHEAD) main registry. Crit Care. 2011;15(6):R291.","DOI":"10.1186\/cc10584"},{"key":"ref119","doi-asserted-by":"crossref","unstructured":"Long B,\u00a0Koyfman A,\u00a0Gottlieb M. Management of\u00a0heart failure\u00a0in the emergency department setting: an evidence-based review of the literature. 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