{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:54:36Z","timestamp":1789584876791,"version":"build-2803163510"},"reference-count":19,"publisher":"Brieflands","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["brieflands.com"],"crossmark-restriction":false},"short-container-title":["Anesth Pain Med"],"abstract":"<jats:p>Background: The Multiwave Locked System (MLS) has been shown to reduce inflammation and enhance biostimulation. Objectives: The aim was to investigate the effect of using MLS laser in reducing pain severity in patients with chronic back pain. Methods: This randomized double-blind study was conducted on 30 patients (15 in each group) with chronic low back pain (LBP) who were referred to Imam Khomeini Hospital and diagnosed by a physical medicine specialist based on diagnostic criteria. The intervention group was treated with MLS multiple wave laser, performed 12 times, with patients receiving laser treatment twice a week. The control group was treated with exercise therapy. Pain intensity was evaluated using the Visual Analog Scale (VAS) before treatment and 6 weeks after treatment. Pain was analyzed before and after the intervention, both within and between groups. Results: Of the 30 evaluated patients, the mean and standard deviation of age (P = 0.392) and gender (P = 0.666) were not statistically significant between the two groups. The VAS value before treatment in the intervention and control groups was 7.66 \u00b1 1.11 and 7.73 \u00b1 1.16, respectively (P = 0.794). After treatment, the VAS values in the MLS and control groups were 5.60 \u00b1 1.35 and 7.73 \u00b1 1.16, respectively. Statistical evaluation showed a statistically significant difference between the two groups (P = 0.001), and the total change in VAS values was significant (P = 0.001). Conclusions: Multiwave Locked System laser can reduce the pain severity of chronic LBP, with the reduction rate in the intervention group being significantly higher than in the exercise group.<\/jats:p>","DOI":"10.5812\/aapm-158778","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T01:03:20Z","timestamp":1740877400000},"update-policy":"https:\/\/doi.org\/10.5812\/crossmark_update_policy","source":"Crossref","is-referenced-by-count":3,"title":["MLS Laser Reduce Pain in Patients with Chronic Low Back Pain"],"prefix":"10.5812","volume":"15","author":[{"given":"Sara","family":"Arefi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Reza","family":"Saidian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamadreza","family":"Mokhtari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryoush","family":"Eliaspour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3819","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"key-A158778REF1-1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-019-0797-6"},{"key":"key-A158778REF2-2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.4292"},{"key":"key-A158778REF3-3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031142"},{"issue":"2-3","key":"key-A158778REF4-4","first-page":"43","volume":"19","author":"Kotova\u00a0OV","year":"2017","journal-title":"Consilium Medicum."},{"key":"key-A158778REF5-5","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1679"},{"key":"key-A158778REF6-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30489-6"},{"key":"key-A158778REF7-7","doi-asserted-by":"publisher","DOI":"10.5272\/jimab.2023293.5079"},{"key":"key-A158778REF8-8","doi-asserted-by":"publisher","DOI":"10.15406\/mojor.2015.02.00068"},{"issue":"80","key":"key-A158778REF9-9","volume":"24","author":"Morshidi\u00a0H","year":"2015","journal-title":"J Isfahan Med School."},{"issue":"79","key":"key-A158778REF10-10","first-page":"69","volume":"20","author":"Akbari\u00a0A","year":"2012","journal-title":"J Adv Med Biomed Res."},{"key":"key-A158778REF11-11","first-page":"15","author":"Olmos\u00a0SR","year":"2016","journal-title":"EnergyHealth."},{"key":"key-A158778REF12-12","doi-asserted-by":"publisher","DOI":"10.23736\/S1973-9087.18.05005-0"},{"issue":"4","key":"key-A158778REF13-13","first-page":"322","volume":"63","author":"Mehrdad R\u00a0","year":"2005","journal-title":"J Faculty Med Tehran Uni Med Sci."},{"key":"key-A158778REF14-14","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-013-1472-5"},{"issue":"4","key":"key-A158778REF15-15","volume":"12","author":"Hadizadeh\u00a0M","year":"2014","journal-title":"Laser in medicine."},{"key":"key-A158778REF16-16","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080139"},{"key":"key-A158778REF17-17","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2014.3715"},{"key":"key-A158778REF18-18","doi-asserted-by":"publisher","DOI":"10.3233\/BMR-170793"},{"key":"key-A158778REF19-19","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/304328"}],"container-title":["Anesthesiology and Pain Medicine"],"original-title":[],"link":[{"URL":"https:\/\/brieflands.com\/articles\/aapm-158778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brieflands.com\/articles\/aapm-158778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:43:29Z","timestamp":1762159409000},"score":1,"resource":{"primary":{"URL":"https:\/\/brieflands.com\/journals\/aapm\/articles\/158778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2,25]]}},"alternative-id":["7b12a52e506148f26f53ff40c2078a45eea13809"],"URL":"https:\/\/doi.org\/10.5812\/aapm-158778","relation":{},"ISSN":["2228-7531"],"issn-type":[{"value":"2228-7531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]}}}