{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:47:37Z","timestamp":1772822857605,"version":"3.50.1"},"reference-count":26,"publisher":"Brieflands","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["brieflands.com"],"crossmark-restriction":false},"short-container-title":["Anesth Pain Med"],"abstract":"<jats:p>Background: A variety of spinal surgery procedures are performed on patients with different cardiac, vascular, and respiratory comorbidities. Postoperative pain management is a major determinant of hemodynamic and respiratory status in these patients and promotes clinical results, prevents complications, saves health services, and improves the quality of life of patients. Objectives: We compared the effects of dexmedetomidine and remifentanil on pain control after spinal surgery. Methods: Sixty patients aged 18 - 65 years undergoing spinal surgery were randomized into the two groups of dexmedetomidine and remifentanil. The dexmedetomidine group (group D, n = 30) received dexmedetomidine infusion (0.6 mcg\/kg\/h), and the remifentanil group (group R, n = 30) received remifentanil infusion (0.1 mcg\/kg\/min) from induction of anesthesia until extubation. Propofol (1.5 mg\/kg) and fentanyl (2mcg\/kg) were used to initiate anesthesia, and propofol (100 - 150 mcg\/kg\/min) was infused to maintain anesthesia. Postoperative pain, hemodynamic parameters, and recovery characteristics were evaluated after surgery. Results: The mean pain intensity in the dexmedetomidine group was significantly lower than in the remifentanil group (2.98 \u00b1 1.29 vs. 3.80 \u00b1 1.1; P &lt; 0.001). Hemodynamic changes in the dexmedetomidine group (MAP: 92.60 \u00b1 5.56, HR: 73.07 \u00b1 7) were less, and their condition was significantly more stable than in the remifentanil group (MAP: 93.85 \u00b1 4.78, HR: 79.15 \u00b1 7.03; P &lt; 0.05). The mean arterial oxygen saturation (O2 sat) in the dexmedetomidine group was significantly higher and more stable than in the remifentanil group (98.87 \u00b1 0.51 vs. 97.92 \u00b1 0.46; P &lt; 0.05). The incidence of nausea and vomiting was significantly lower in the dexmedetomidine group compared to the remifentanil group (P &lt; 0.05). The administration of analgesics in the post-anesthetic care unit (PACU) was significantly higher in the remifentanil group than the dexmedetomidine group (P = 0.016). Conclusions: Anesthetic maintenance with either dexmedetomidine or remifentanil infusion until extubation provided more smooth and hemodynamically stable conditions, without complications. However, dexmedetomidine provides better analgesia, causes a more stable hemodynamic state, and reduces postoperative nausea-vomiting, shivering, and the need for analgesics.<\/jats:p>","DOI":"10.5812\/aapm.111533","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T02:18:16Z","timestamp":1620440296000},"update-policy":"https:\/\/doi.org\/10.5812\/crossmark_update_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of the Effect of Dexmedetomidine and Remifentanil on Pain Control After Spinal Surgery: A Double-Blind, Randomized Clinical 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