{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:42:23Z","timestamp":1790876543556,"version":"4.1.0"},"reference-count":24,"publisher":"Brieflands","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["brieflands.com"],"crossmark-restriction":false},"short-container-title":["Anesth Pain Med"],"abstract":"<jats:p>Background: Phenylephrine is used to prevent and treat hypotension during spinal anesthesia for cesarean delivery. Objectives: The present study aims to investigate the effects of different regimens of phenylephrine on blood pressure of candidates for the cesarean section. Methods: In this double-blind, randomized clinical trial, a total of 120 candidates of elective cesarean delivery under spinal anesthesia was randomly categorized into three groups. Groups 1, 2, and 3 received bolus and prophylactic saline (control group), prophylactic bolus phenylephrine (100 \u00b5g), and prophylactic phenylephrine infusion (50 \u00b5g\/min), respectively. The incidence of hypotension, maternal hemodynamics, hypertension, rescue phenylephrine dose, nausea, and vomit were compared between the groups. Results: In all the three groups, the incidence of nausea and vomit, bradycardia, hypertension, and neonatal Apgar score were not statistically different (P &gt; 0.05). However, the adjuvant phenylephrine dose requirement was remarkably different. Moreover, the mean systolic blood pressure differed significantly in the second and 7th minutes after the spinal block (P &lt; 0.05). 35% in the first group, 15% in the second group, and 2.5% in the third group had hypotension (P = 0.001). Apart from the first measurement after spinal anesthesia, the mean heart rate showed no significant difference between the groups. Conclusions: The use of prophylactic phenylephrine infusion is recommended to control the optimal blood pressure in parturients undergoing cesarean section after spinal anesthesia.<\/jats:p>","DOI":"10.5812\/aapm.58048","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T01:54:03Z","timestamp":1595123643000},"update-policy":"https:\/\/doi.org\/10.5812\/crossmark_update_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Clinical Trial on the Effects of Different Regimens of Phenylephrine on Maternal Hemodynamic After Spinal Anesthesia for Cesarean Section"],"prefix":"10.5812","volume":"10","author":[{"given":"Mahshid","family":"Nikooseresht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ali","family":"Seifrabiei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouran","family":"Hajian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadab","family":"Khamooshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3819","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"key-A58048REF1-1","doi-asserted-by":"publisher","DOI":"10.5812\/kowsar.22287523.1271"},{"key":"key-A58048REF2-2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004350.pub3"},{"key":"key-A58048REF3-3","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.71037"},{"issue":"1","key":"key-A58048REF4-4","first-page":"9","volume":"79","author":"Di Cianni\u00a0S","year":"2008","journal-title":"Acta Biomed."},{"key":"key-A58048REF5-5","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.11519"},{"key":"key-A58048REF6-6","doi-asserted-by":"publisher","DOI":"10.1007\/s40140-013-0036-3"},{"key":"key-A58048REF7-7","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.128923"},{"key":"key-A58048REF8-8","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.43462"},{"key":"key-A58048REF9-9","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3462529"},{"key":"key-A58048REF10-10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013947"},{"key":"key-A58048REF11-11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2012.00345.x"},{"key":"key-A58048REF12-12","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181b160a3"},{"key":"key-A58048REF13-13","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_204_17"},{"key":"key-A58048REF14-14","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00002"},{"key":"key-A58048REF15-15","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000001174"},{"key":"key-A58048REF16-16","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12445"},{"key":"key-A58048REF17-17","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000437731.60260.ce"},{"key":"key-A58048REF18-18","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181e1db21"},{"key":"key-A58048REF19-19","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.7850"},{"key":"key-A58048REF20-20","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31826ac3db"},{"key":"key-A58048REF21-21","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.65.4.293"},{"issue":"10","key":"key-A58048REF22-22","first-page":"918","volume":"17","author":"Faiz\u00a0SH","year":"2012","journal-title":"J Res Med Sci."},{"key":"key-A58048REF23-23","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-017-1034-6"},{"key":"key-A58048REF24-24","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh088"}],"container-title":["Anesthesiology and Pain Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aapm.kowsarpub.com\/cdn\/dl\/fcca6300-e95e-11ea-a049-93a29a0ba3fa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sites.kowsarpub.com\/aapm\/articles\/58048.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:27:17Z","timestamp":1762158437000},"score":1,"resource":{"primary":{"URL":"https:\/\/brieflands.com\/journals\/aapm\/articles\/58048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,19]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,7,19]]}},"alternative-id":["3969c7221c55a9d05cb2013847bb54ce270eae3c"],"URL":"https:\/\/doi.org\/10.5812\/aapm.58048","relation":{},"ISSN":["2228-7523","2228-7531"],"issn-type":[{"value":"2228-7523","type":"print"},{"value":"2228-7531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,19]]}}}