{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:30:14Z","timestamp":1762165814802,"version":"build-2065373602"},"reference-count":24,"publisher":"Brieflands","issue":"2","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["brieflands.com"],"crossmark-restriction":false},"short-container-title":["Int J Endocrinol Metab"],"abstract":"<jats:p>Background: Primary hyperaldosteronism (PHA) is a common cause of secondary arterial hypertension (AH), characterized by autonomous aldosterone secretion. It is frequently underdiagnosed and may persist even after surgical intervention. Objectives: The present study aimed to identify preoperative factors that could predict whether hypertension would persist or normalize following surgery and to outline relevant diagnostic characteristics. Methods: We conducted a descriptive, analytic, retrospective cohort study at a single center. The study included patients with PHA who were followed up at the Department of Endocrinology, Diabetology, and Nutrition in a hospital affiliated with Mohamed the First University of Oujda (CERBO), admitted between December 2014 and August 2023. Data were retrospectively collected from patient records over a 9-year period, involving 27 patients with PHA confirmed by an elevated aldosterone-to-renin ratio (ARR). Persistent disease was defined by persistent hypokalemia and hypertension (blood pressure &gt; 140\/90 mm Hg) after six months. Patients were divided into two groups: Those with complete resolution of hypertension (group A) and those with persistent hypertension (group B). Data were analyzed using SPSS version 21. Results: The mean age of patients was 48.47 \u00b1 10.87 years, with a female predominance (66.7%). The etiological assessment identified Conn\u2019s adenoma in 70.4% (n = 19) of cases and bilateral adrenal hyperplasia in 29.6% (n = 8). Surgery was performed in 51.9% (n = 14) of cases, with 50% (n = 7) maintaining persistent hypertension post-surgery, while 28.6% (n = 4) showed a reduction in antihypertensive medications. Two predictive factors for persistent hypertension were identified: Age &gt; 50 years and hypertension duration &gt; 5 years. Predictive factors for normalization of hypertension post-surgery included systolic blood pressure (SBP) &lt; 140 mm Hg, diastolic blood pressure (DBP) &lt; 90 mm Hg, glomerular filtration rate (GFR) &gt; 90 mL\/min\/1.75 m2, and a low incidence of diabetes and dyslipidemia. Conclusions: This study demonstrates that PHA can lead to resistant hypertension, highlighting the necessity for further research in this area.<\/jats:p>","DOI":"10.5812\/ijem-156728","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T02:56:43Z","timestamp":1748746603000},"update-policy":"https:\/\/doi.org\/10.5812\/crossmark_update_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Predictive Risk Factors of Persistent Hypertension in Hyperaldosteronism After Surgery"],"prefix":"10.5812","volume":"23","author":[{"given":"Amal","family":"Ourdi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssra","family":"Laalaoua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imane","family":"Assarrar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bouichrat","family":"Nisrine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siham","family":"Rouf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanane","family":"Latrech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3819","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"issue":"1","key":"key-A156728REF1-1","first-page":"3","volume":"45","author":"Conn\u00a0JW","year":"1955","journal-title":"J Lab Clin Med."},{"key":"key-A156728REF2-2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.161486"},{"key":"key-A156728REF3-3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031337"},{"key":"key-A156728REF4-4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1994.tb02519.x"},{"key":"key-A156728REF5-5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059"},{"key":"key-A156728REF6-6","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1100356"},{"key":"key-A156728REF7-7","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.033990"},{"key":"key-A156728REF8-8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2016.02.003"},{"key":"key-A156728REF9-9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2014.07.678"},{"key":"key-A156728REF10-10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2013.07.272"},{"key":"key-A156728REF11-11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2017.07.160"},{"key":"key-A156728REF12-12","doi-asserted-by":"publisher","DOI":"10.1055\/a-0654-5251"},{"key":"key-A156728REF13-13","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.7.1041"},{"key":"key-A156728REF14-14","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.12.042"},{"key":"key-A156728REF15-15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2013.07.339"},{"key":"key-A156728REF16-16","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2020.901"},{"key":"key-A156728REF17-17","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-5-200909010-00007"},{"key":"key-A156728REF18-18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3789"},{"key":"key-A156728REF19-19","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.20.85"},{"key":"key-A156728REF20-20","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-013-1007-x"},{"journal-title":"Place du catheterisme veineux surr\u00e9nalien: evaluation des pratiques au CHU de Grenoble.","year":"2011","author":"Naem\u00a0N","key":"key-A156728REF21-21"},{"key":"key-A156728REF22-22","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283060f0c"},{"key":"key-A156728REF23-23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-39028-2"},{"key":"key-A156728REF24-24","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318165c075"}],"container-title":["International Journal of Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/brieflands.com\/articles\/ijem-156728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brieflands.com\/articles\/ijem-156728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:21:55Z","timestamp":1762165315000},"score":1,"resource":{"primary":{"URL":"https:\/\/brieflands.com\/journals\/ijem\/articles\/156728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4,30]]}},"alternative-id":["1deaa2c0726a45d75de5c4eb1b1d00e008393963"],"URL":"https:\/\/doi.org\/10.5812\/ijem-156728","relation":{},"ISSN":["1726-9148"],"issn-type":[{"type":"electronic","value":"1726-9148"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}