{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:38:21Z","timestamp":1787859501757,"version":"build-2784847793"},"reference-count":23,"publisher":"Brieflands","issue":"4","license":[{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["brieflands.com"],"crossmark-restriction":false},"short-container-title":["Int J Endocrinol Metab"],"abstract":"<jats:p>Introduction: Sertoli cell tumors are rare sex cord-stromal tumors, accounting for less than 1% of primary testicular tumors. They typically arise in the testes and ovaries, with other localizations being uncommon. We present the case of a Sertoli cell tumor in the adrenal gland, which, to our knowledge, is the first reported in the literature. Case Presentation: A 44-year-old male patient was admitted to the clinic for endocrine surgery for laparoscopic surgery of a right adrenal gland incidentaloma measuring 57 \u00d7 47 \u00d7 59 mm, discovered during a routine abdominal ultrasonography. The patient had a history of hypertension but no other comorbidities. Biochemical and physical examinations revealed no signs of hypercortisolism. Urinary metanephrine and normetanephrine levels were within normal limits. A right laparoscopic adrenalectomy was performed, and a 5 cm tumor was identified without evidence of locoregional invasion. Pathological examination confirmed a Sertoli cell tumor of the adrenal gland. Immunohistochemical analysis revealed positive staining for vimentin, steroidogenic factor 1 (SF1), and beta-catenin, while chromogranin A, hCG, PSA, and TTF1 were negative. The Ki-67 index was 3%. The patient was subsequently referred to a urologist, where testicular ultrasonography showed no abnormalities. There were no signs of recurrence during a 15-month follow-up period. Additionally, the patient\u2019s biannual antihypertensive treatment was discontinued by a cardiologist 1.5 months post-surgery. Conclusions: Sertoli cell tumors are an exceptionally rare entity. To our knowledge, this is the first reported case of a primary Sertoli cell tumor originating in the adrenal gland. Given their potential for malignancy, regular follow-up and additional diagnostic evaluations may be necessary. Laparoscopic adrenalectomy appears to be a suitable definitive treatment for this condition.<\/jats:p>","DOI":"10.5812\/ijem-156823","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:13:18Z","timestamp":1737331998000},"update-policy":"https:\/\/doi.org\/10.5812\/crossmark_update_policy","source":"Crossref","is-referenced-by-count":1,"title":["The First Sertoli Cell Tumor of the Adrenal Gland is Potentially Associated with Arterial Hypertension"],"prefix":"10.5812","volume":"22","author":[{"given":"Sara","family":"Ivanis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Marinkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Jovanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matija","family":"Buzejic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Milinkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlatibor","family":"Loncar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladan","family":"Zivaljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branislav","family":"Rovcanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3819","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"key-A156823REF1-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100152"},{"key":"key-A156823REF2-2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/22075.8842"},{"key":"key-A156823REF3-3","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2014.48.1.50"},{"key":"key-A156823REF4-4","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2023.102628"},{"key":"key-A156823REF5-5","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2011.11.007"},{"key":"key-A156823REF6-6","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2016.1215869"},{"key":"key-A156823REF7-7","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58111638"},{"key":"key-A156823REF8-8","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-023-01351-7"},{"key":"key-A156823REF9-9","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5892"},{"key":"key-A156823REF10-10","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/439239"},{"key":"key-A156823REF11-11","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.04.021"},{"key":"key-A156823REF12-12","doi-asserted-by":"publisher","DOI":"10.23937\/2469-5807\/1510080"},{"key":"key-A156823REF13-13","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2019.30.e19"},{"key":"key-A156823REF14-14","doi-asserted-by":"publisher","DOI":"10.1159\/000068770"},{"key":"key-A156823REF15-15","doi-asserted-by":"publisher","DOI":"10.1111\/his.13115"},{"key":"key-A156823REF16-16","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31817c1b0a"},{"key":"key-A156823REF17-17","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0692"},{"issue":"4","key":"key-A156823REF18-18","first-page":"281","volume":"7","author":"Golombos\u00a0D","year":"2010","journal-title":"Urol J."},{"key":"key-A156823REF19-19","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-008-9396-x"},{"key":"key-A156823REF20-20","doi-asserted-by":"publisher","DOI":"10.1016\/s0242-6498(04)93896-5"},{"key":"key-A156823REF21-21","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2015.12.003"},{"key":"key-A156823REF22-22","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/85.2.242"},{"key":"key-A156823REF23-23","doi-asserted-by":"publisher","DOI":"10.4158\/ep15800.Cr"}],"container-title":["International Journal of Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/brieflands.com\/articles\/ijem-156823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brieflands.com\/articles\/ijem-156823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:21:56Z","timestamp":1762165316000},"score":1,"resource":{"primary":{"URL":"https:\/\/brieflands.com\/journals\/ijem\/articles\/156823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,10,30]]}},"alternative-id":["d062b5d8a033da7d03913a2bf99d5ed0880fbf78"],"URL":"https:\/\/doi.org\/10.5812\/ijem-156823","relation":{},"ISSN":["1726-9148"],"issn-type":[{"value":"1726-9148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]}}}