{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:38:19Z","timestamp":1791041899608,"version":"4.1.0"},"reference-count":18,"publisher":"Brieflands","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["brieflands.com"],"crossmark-restriction":false},"short-container-title":["Int J Endocrinol Metab"],"abstract":"<jats:p>Background: Noonan syndrome is an autosomal dominant condition with an incidence of 1:1000 to 1:2500. The disorder is associated with distinct dysmorphic features, cardiac anomalies, developmental delay and delayed puberty. Short stature is a recognised feature of Noonan syndrome. Objectives: The aim of this study is to assess the effect of growth hormone treatment in patients with Noonan syndrome. Methods: Retrospective data was collected from patients with Noonan syndrome treated with growth hormone. The results were analysed with variables expressed as mean values and standard deviation scores. Results: Twelve Noonan syndrome patients (M: F = 10:2) treated with growth hormone were identified. The mean age of starting growth hormone was 8 years, with baseline height standard deviation score of -2.96 (range: -1.64 to -5.54). The height standard deviation score significantly improved to -2.50 (P = 0.0035) and then -2.22 (P = 0.0025), following one and two years of treatment, respectively. The average height velocity for the patients prior to starting treatment was 5.16cm\/year (range: 2.4 - 8.2 cm\/year), which significantly improved to 7.76cm\/year (ranging from 4.1 to 12.8 cm\/year) after one year of growth hormone treatment (P = 0.020) and to 6.51cm\/year at the end of two years. Conclusions: Our study has shown that growth hormone treatment significantly improves the height standard deviation score of patients with Noonan syndrome over a two-year course of growth hormone therapy without any side effects. Further research is required to analyse the long-term effect of growth hormone therapy in patients with Noonan syndrome, including the impact on final adult height.<\/jats:p>","DOI":"10.5812\/ijem.107292","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T09:34:30Z","timestamp":1603445670000},"update-policy":"https:\/\/doi.org\/10.5812\/crossmark_update_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Growth Hormone Therapy in Patients with Noonan Syndrome: A Retrospective Study"],"prefix":"10.5812","volume":"18","author":[{"given":"Louise Jayne","family":"Apperley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9864-5303","authenticated-orcid":false,"given":"Renuka","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-1862","authenticated-orcid":false,"given":"Poonam","family":"Dharmaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-8780","authenticated-orcid":false,"given":"Urmi","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-3276","authenticated-orcid":false,"given":"Mohammed","family":"Didi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-5574","authenticated-orcid":false,"given":"Jo","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8001-0342","authenticated-orcid":false,"given":"Senthil","family":"Senniappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3819","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"key-A107292REF1-1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2018.23.4.176"},{"key":"key-A107292REF2-2","doi-asserted-by":"publisher","DOI":"10.1159\/000369012"},{"key":"key-A107292REF3-3","doi-asserted-by":"publisher","DOI":"10.1159\/000371635"},{"key":"key-A107292REF4-4","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.5.7468"},{"key":"key-A107292REF5-5","doi-asserted-by":"publisher","DOI":"10.1159\/000243773"},{"key":"key-A107292REF6-6","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27625"},{"key":"key-A107292REF7-7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01641.x"},{"key":"key-A107292REF8-8","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12568"},{"key":"key-A107292REF9-9","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.37"},{"key":"key-A107292REF10-10","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.5.440"},{"key":"key-A107292REF11-11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.02.043"},{"key":"key-A107292REF12-12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01188.x"},{"key":"key-A107292REF13-13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0983"},{"key":"key-A107292REF14-14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0995"},{"key":"key-A107292REF15-15","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-015-0183-x"},{"key":"key-A107292REF16-16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2094"},{"key":"key-A107292REF17-17","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2019.24.2.92"},{"key":"key-A107292REF18-18","doi-asserted-by":"publisher","DOI":"10.1159\/000479107"}],"container-title":["International Journal of Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/ijem.kowsarpub.com\/cdn\/dl\/7e01befe-22b3-11eb-a344-67962f7b49cd","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sites.kowsarpub.com\/ijem\/articles\/107292.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:21:35Z","timestamp":1762165295000},"score":1,"resource":{"primary":{"URL":"https:\/\/brieflands.com\/journals\/ijem\/articles\/107292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,10,23]]}},"alternative-id":["24a0a7ee8d75663f6426f37dd1ba5e93a9c7ee20"],"URL":"https:\/\/doi.org\/10.5812\/ijem.107292","relation":{},"ISSN":["1726-913X","1726-9148"],"issn-type":[{"value":"1726-913X","type":"print"},{"value":"1726-9148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,23]]}}}