{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:14:05Z","timestamp":1783080845149,"version":"3.54.6"},"reference-count":41,"publisher":"Brieflands","issue":"1","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["brieflands.com"],"crossmark-restriction":false},"short-container-title":["Iran J Pharm Res"],"abstract":"<jats:p>Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a potential complication that can develop following cancer chemotherapy. Objectives: Due to limited medical interventions for the prevention and management of CIPN caused by vincristine, a painful and common complication, further research to find the mechanisms of CIPN and the development of effective preventive and therapeutic strategies is needed. Methods: We induced CIPN in male Wistar rats by administering intraperitoneal vincristine (VCR) at a dose of 0.1 mg\/kg for 10 days. Treatment involved micronized purified flavonoid fraction (MPFF) containing hesperidin and diosmin (MPFF; Daflon\u00ae) at doses of 50, 100, and 200 mg\/kg. Our investigation focused on levels of inflammatory factors (TNF-\u03b1, IL-6) in the dorsal root ganglion (DRG) tissue and included a series of behavioral tests: Von Frey, grip strength, rotarod, open field, and hot plate tests. To examine the role of the nitric oxide (NO) pathway in the effects of MPFF on VCR-induced peripheral neuropathy (VIPN), we also tested the effect of L-arginine (100 mg\/kg i.p.) as a NO precursor and L-NAME (20 mg\/kg i.p.) as a nitric oxide synthase (NOS) inhibitor. Results: Based on our behavioral tests, MPFF (50, 100, 200 mg\/kg) effectively reduced some symptoms of VIPN, including mechanical allodynia and hyperalgesia. Notably, TNF-\u03b1 and IL-6 levels in the DRG tissue of the groups treated with 100 and 200 mg\/kg of MPFF showed a significant reduction in inflammatory factors. These results underscore the potential of MPFF and the role of the NO signaling pathway in alleviating neuropathic pain caused by VCR. Conclusions: Micronized purified flavonoid fraction may be an effective treatment for VIPN by reducing mechanical allodynia, thermal hyperalgesia, and TNF-\u03b1 and IL-6 levels in DRG tissue. The NO pathway may play a role in the effectiveness of MPFF in treating VIPN.<\/jats:p>","DOI":"10.5812\/ijpr-154455","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T05:21:01Z","timestamp":1730524861000},"update-policy":"https:\/\/doi.org\/10.5812\/crossmark_update_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Micronized Purified Flavonoid Fraction Containing Hesperidin and Diosmin on Vincristine-Induced Neuropathy in Rats; the Role of Nitric Oxide Pathway"],"prefix":"10.5812","volume":"24","author":[{"given":"Nikoo","family":"Abharian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Naderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noushin","family":"Nikray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Khoramjouy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shokoofe","family":"Noori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Shafaroodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Faizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3819","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"key-A154455REF1-1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.693133"},{"key":"key-A154455REF2-2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11070940"},{"key":"key-A154455REF3-3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00156"},{"key":"key-A154455REF4-4","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.102831"},{"key":"key-A154455REF5-5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2020.10.004"},{"key":"key-A154455REF6-6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2023.08.002"},{"key":"key-A154455REF7-7","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-022-02254-y"},{"key":"key-A154455REF8-8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.04.075"},{"key":"key-A154455REF9-9","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02218-x"},{"key":"key-A154455REF10-10","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpta.2023.100419"},{"key":"key-A154455REF11-11","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10051076"},{"key":"key-A154455REF12-12","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphar.2022.100122"},{"key":"key-A154455REF13-13","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023666230320144722"},{"key":"key-A154455REF14-14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114222"},{"key":"key-A154455REF15-15","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-021-00959-y"},{"key":"key-A154455REF16-16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00887"},{"key":"key-A154455REF17-17","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13399"},{"key":"key-A154455REF18-18","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2020.1101230"},{"key":"key-A154455REF19-19","doi-asserted-by":"publisher","DOI":"10.1186\/s41110-019-0098-1"},{"key":"key-A154455REF20-20","doi-asserted-by":"publisher","DOI":"10.3390\/ph14010030"},{"key":"key-A154455REF21-21","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001601"},{"key":"key-A154455REF22-22","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.343080"},{"key":"key-A154455REF23-23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53263-6"},{"key":"key-A154455REF24-24","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2020.113738.14458"},{"key":"key-A154455REF25-25","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-015-0958-9"},{"key":"key-A154455REF26-26","doi-asserted-by":"publisher","DOI":"10.1038\/srep21582"},{"key":"key-A154455REF27-27","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12120775"},{"key":"key-A154455REF28-28","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040803"},{"key":"key-A154455REF29-29","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107060"},{"key":"key-A154455REF30-30","doi-asserted-by":"publisher","DOI":"10.47750\/pnr.2022.13.S08.435"},{"key":"key-A154455REF31-31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010255"},{"key":"key-A154455REF32-32","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713483192"},{"key":"key-A154455REF33-33","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120104"},{"key":"key-A154455REF34-34","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091721"},{"key":"key-A154455REF35-35","doi-asserted-by":"publisher","DOI":"10.1016\/S2095-4964(14)60001-7"},{"key":"key-A154455REF36-36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.06.014"},{"key":"key-A154455REF37-37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.077"},{"key":"key-A154455REF38-38","doi-asserted-by":"publisher","DOI":"10.1039\/c4fo00144c"},{"key":"key-A154455REF39-39","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2013.06.007"},{"key":"key-A154455REF40-40","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6425"},{"issue":"6","key":"key-A154455REF41-41","first-page":"306","volume":"6","author":"Abdel-Salam\u00a0OM","year":"2012","journal-title":"Drug Discov Ther."}],"container-title":["Iranian Journal of Pharmaceutical Research"],"original-title":[],"link":[{"URL":"https:\/\/brieflands.com\/articles\/ijpr-154455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brieflands.com\/articles\/ijpr-154455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:05:14Z","timestamp":1762167914000},"score":1,"resource":{"primary":{"URL":"https:\/\/brieflands.com\/journals\/ijpr\/articles\/154455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,2]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,11,2]]}},"alternative-id":["7739d4aae27a232cdcefe8459360a567f777fbaa"],"URL":"https:\/\/doi.org\/10.5812\/ijpr-154455","relation":{},"ISSN":["1726-6890"],"issn-type":[{"value":"1726-6890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,2]]},"assertion":[{"value":"2024-9-8","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-9-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-9-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"Article is imported on 2024-11-02 09:20:47 by user ID: 241665.","name":"import","label":"Import","group":{"name":"import_history","label":"Import History"}}]}}