{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:02:35Z","timestamp":1777514555980,"version":"3.51.4"},"reference-count":55,"publisher":"Brieflands","issue":"5","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["brieflands.com"],"crossmark-restriction":false},"short-container-title":["Int J Cancer Manag"],"abstract":"<jats:p>Background: Adherence to the treatment regimen is among the behaviors, which predict the successful control of the disease and decrease its intensity and negative consequences, which is influenced by several factors. The patient's beliefs and attitudes toward the disease are effective factors in disease management and adherence to treatment, and spiritual health is one of these influential variables. Objectives: The aim of this study was to determine the mediating role of spiritual health in adherence to treatment in patients with cancer. Methods: In this descriptive correlational study, the participants were 234 Iranian patients with cancer, who were selected through convenience sampling, admitted to the oncology wards of 9 selected teaching hospitals in the northern, southern, eastern, and western provinces of the country, as well as the capital in 2021. The research instruments included the Demographic and Clinical Information Questionnaire, Spiritual Well-Being Scale, and Morisky Medication Adherence Scale-8. The path analysis was done to determine the factors related to the degree of adherence to treatment, taking into account the mediating role of spiritual health. Results: The mean age of the participants in the study was 47.27 \u00b1 15.36. The mean scores for spiritual health and adherence to treatment were 76.70 \u00b1 13.75 and 6.47 \u00b1 2.1, respectively. A positive and significant relationship was found between spiritual health and adherence to treatment (P-value &lt; 0.05). The variables of marital status, the time of diagnosis, and being a religious person had a direct effect on spiritual health, and the time of diagnosis indirectly affected treatment adherence. Conclusions: According to the results, the level of spiritual health and adherence to the treatment in patients with cancer was moderate. In addition, the variable of diagnostic time affected adherence to treatment indirectly. Besides, in examining the factors affecting spiritual health, the findings indicated the effect of the variables \u201cbeing religious\u201d, \u201cmarital status\u201d, and \u201cthe time of diagnosis\u201d. In addition to strengthening spiritual health, it is necessary to highlight the need to follow therapeutic diets in these patients. Therefore, it is suggested to consider a program to meet the patients with cancer spiritual needs along with the physical care program.<\/jats:p>","DOI":"10.5812\/ijcm-127820","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T05:36:07Z","timestamp":1658036167000},"update-policy":"https:\/\/doi.org\/10.5812\/crossmark_update_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Mediating Role of Spiritual Health in Adherence to Treatment in Patients with Cancer"],"prefix":"10.5812","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-7642","authenticated-orcid":false,"given":"Azam","family":"Shirinabadi Farahani","sequence":"first","affiliation":[]},{"given":"Hadis","family":"Ashrafizadeh","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9938-3587","authenticated-orcid":false,"given":"Mohammad Esmaeil","family":"Akbari","sequence":"additional","affiliation":[]},{"given":"Sanaz","family":"Motefakker","sequence":"additional","affiliation":[]},{"given":"Fatemeh","family":"Khademi","sequence":"additional","affiliation":[]},{"given":"Saba","family":"Ebrahimloee","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8824-2543","authenticated-orcid":false,"given":"Maryam","family":"Karami","sequence":"additional","affiliation":[]},{"given":"Reihane","family":"Moghimian","sequence":"additional","affiliation":[]},{"given":"Raheleh","family":"Razmara","sequence":"additional","affiliation":[]},{"given":"Wilson","family":"Abreu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-8064","authenticated-orcid":false,"given":"Maryam","family":"Rassouli","sequence":"additional","affiliation":[]}],"member":"3819","published-online":{"date-parts":[[2022,7,17]]},"reference":[{"key":"key-A127820REF1-1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33574"},{"key":"key-A127820REF2-2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"key-A127820REF3-3","doi-asserted-by":"publisher","DOI":"10.14338\/ijpt-15-00013"},{"issue":"6","key":"key-A127820REF4-4","first-page":"491","volume":"12","author":"Ebrahimi\u00a0H","year":"2014","journal-title":"Nurs Midwifery J."},{"issue":"85","key":"key-A127820REF5-5","first-page":"44","volume":"26","author":"Masror Roudsari\u00a0DD","year":"2013","journal-title":"Iran J Nurs."},{"key":"key-A127820REF6-6","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2015.05.009"},{"key":"key-A127820REF7-7","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4362"},{"key":"key-A127820REF8-8","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12601"},{"key":"key-A127820REF9-9","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002606"},{"key":"key-A127820REF10-10","doi-asserted-by":"publisher","DOI":"10.1097\/01.HNP.0000334919.39057.14"},{"key":"key-A127820REF11-11","doi-asserted-by":"publisher","DOI":"10.52547\/rbs.16.4.466"},{"issue":"3 #d0011","key":"key-A127820REF12-12","volume":"20","author":"Fallahi\u00a0S","year":"2018","journal-title":"Iran J Endocrinol Metab."},{"key":"key-A127820REF13-13","doi-asserted-by":"publisher","DOI":"10.1097\/HNP.0000000000000263"},{"key":"key-A127820REF14-14","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20160076"},{"key":"key-A127820REF15-15","doi-asserted-by":"publisher","DOI":"10.1037\/ort0000255"},{"key":"key-A127820REF16-16","doi-asserted-by":"publisher","DOI":"10.4103\/apjon.apjon_69_18"},{"key":"key-A127820REF17-17","doi-asserted-by":"publisher","DOI":"10.22038\/mjms.2019.13994"},{"issue":"2 #S00184","key":"key-A127820REF18-18","first-page":"20","volume":"4","author":"Mohammadizadeh\u00a0A","year":"2017","journal-title":"J Relig Health."},{"key":"key-A127820REF19-19","doi-asserted-by":"publisher","DOI":"10.21859\/jech-02042"},{"key":"key-A127820REF20-20","doi-asserted-by":"publisher","DOI":"10.1080\/13674676.2019.1674796"},{"key":"key-A127820REF21-21","doi-asserted-by":"publisher","DOI":"10.21859\/ijpn-07067"},{"key":"key-A127820REF22-22","doi-asserted-by":"publisher","DOI":"10.1177\/009164718301100406"},{"key":"key-A127820REF23-23","doi-asserted-by":"publisher","DOI":"10.1017\/S147895151600081X"},{"issue":"3","key":"key-A127820REF24-24","first-page":"276","volume":"43","author":"Biglari Abhari\u00a0M","year":"2018","journal-title":"Iran J Med Sci."},{"key":"key-A127820REF25-25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2008.07572.x"},{"key":"key-A127820REF26-26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2012.00634.x"},{"issue":"4 #F00277","key":"key-A127820REF27-27","first-page":"47","volume":"6","author":"Kazemi Majd\u00a0R","year":"2017","journal-title":"J Nurs Educ."},{"key":"key-A127820REF28-28","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)13310-7"},{"key":"key-A127820REF29-29","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.116"},{"issue":"3","key":"key-A127820REF30-30","first-page":"205","volume":"24","author":"Sajjadi\u00a0M","year":"2017","journal-title":"J Sabzevar Univ Med Sci."},{"key":"key-A127820REF31-31","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000282"},{"key":"key-A127820REF32-32","author":"Lombardi\u00a0C","year":"2014","journal-title":"Patient adherence to oral cancer therapies: a nursing resource guide."},{"key":"key-A127820REF33-33","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt433"},{"key":"key-A127820REF34-34","doi-asserted-by":"publisher","DOI":"10.21859\/ijpn-060610"},{"key":"key-A127820REF35-35","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0b013e318244afe0"},{"key":"key-A127820REF36-36","doi-asserted-by":"publisher","DOI":"10.1177\/0898010119858269"},{"issue":"1","key":"key-A127820REF37-37","first-page":"104","volume":"8","author":"Rezaie\u00a0AM","year":"2012","journal-title":"Health Sys Res."},{"key":"key-A127820REF38-38","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2014.15.9.3933"},{"key":"key-A127820REF39-39","doi-asserted-by":"publisher","DOI":"10.1007\/s10926-015-9622-1"},{"issue":"3","key":"key-A127820REF40-40","volume":"12","author":"Allahbakhshian\u00a0M","year":"2010","journal-title":"Zahedan J Res Med Sci."},{"issue":"3","key":"key-A127820REF41-41","first-page":"7","volume":"5","author":"Agha Hosseini\u00a0S","year":"2011","journal-title":"Qom Univ Med Sci J."},{"issue":"2","key":"key-A127820REF42-42","first-page":"43","volume":"3","author":"Shahdadi\u00a0H","year":"2015","journal-title":"J Diabetes Nurs."},{"key":"key-A127820REF43-43","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-020-00586-1"},{"key":"key-A127820REF44-44","doi-asserted-by":"publisher","DOI":"10.4102\/phcfm.v9i1.1411"},{"key":"key-A127820REF45-45","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1775"},{"key":"key-A127820REF46-46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.06.321"},{"key":"key-A127820REF47-47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.12.014"},{"key":"key-A127820REF48-48","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12441"},{"key":"key-A127820REF49-49","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(94)00021-f"},{"key":"key-A127820REF50-50","doi-asserted-by":"publisher","DOI":"10.21859\/psj.17.1.37"},{"issue":"2","key":"key-A127820REF51-51","first-page":"3","volume":"1","author":"Ebrahimipour\u00a0H","year":"2015","journal-title":"J Reas Relig Health."},{"key":"key-A127820REF52-52","doi-asserted-by":"publisher","DOI":"10.4172\/2165-7386.1000249"},{"key":"key-A127820REF53-53","doi-asserted-by":"publisher","DOI":"10.3402\/ejpt.v5.23970"},{"key":"key-A127820REF54-54","author":"Young\u00a0C","year":"2010","journal-title":"Spirituality, health, and healing: An integrative approach."},{"issue":"1","key":"key-A127820REF55-55","first-page":"9","volume":"2","author":"Janbabaei\u00a0G","year":"2014","journal-title":"J Relig Health."}],"container-title":["International Journal of Cancer Management"],"original-title":[],"link":[{"URL":"https:\/\/brieflands.com\/articles\/ijcm-127820.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brieflands.com\/articles\/ijcm-127820.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:00:48Z","timestamp":1762164048000},"score":1,"resource":{"primary":{"URL":"https:\/\/brieflands.com\/journals\/ijcm\/articles\/127820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,17]]},"references-count":55,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,7,17]]}},"alternative-id":["4583c1fcc292966098aaceafb1a6dec4d6d967da"],"URL":"https:\/\/doi.org\/10.5812\/ijcm-127820","relation":{},"ISSN":["2538-4422","2538-497X"],"issn-type":[{"value":"2538-4422","type":"print"},{"value":"2538-497X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,17]]},"assertion":[{"value":"Article is imported on 2022-07-17 09:35:59 by user ID: 142217.","name":"import","label":"Import","group":{"name":"import_history","label":"Import History"}},{"value":"2022-5-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-6-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-6-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"Article is imported on 2022-09-06 07:01:55 by user ID: 126266.","name":"import","label":"Import","group":{"name":"import_history","label":"Import History"}}]}}