{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:50:57Z","timestamp":1792381857411,"version":"4.4.0"},"reference-count":0,"publisher":"Mattioli1885","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>Background: Acanthosis nigricans (AN) develops sporadically or in association with obesity, insulin-resistance and dark pigmentary phenotype. Unusual clinical presentations of AN may be diagnostically vexing.\r\nObjectives: The aim of the report is to present unusual clinical and dermoscopic pictures of hyperkeratotic, brownish lesions of the nipples resembling acanthosis nigricans.\r\nPatients\/Methods: Data including clinical and dermoscopic features of two patients with the \u201cneglected nipples\u201d: acanthosis nigricans-like (AN-like) hyperpigmented plaques caused by avoidance of nipple cleansing.\r\nResults: Beside the anamnestic clue, presentation of AN-like plaques in the \u201cneglected nipples\u201d is limited to the breasts, in the absence of involvement of other flexural sites classically affected by AN.Dermoscopy aids the exclusion of a tumor, as it reveals exclusively structureless, brown-gray-black hyperkeratosis in the absence of criteria associated with melanocytic or non-melanocytic skin neoplasms of the nipple. The \u201cneglected breasts\u201d are easily treated by keratolytic creams and hygiene.\r\nConclusions: The \u201cneglected nipples\u201d condition, presenting as bilateral AN-like papules and plaques of the nipples, is due to avoidance of cleansing of the nipple area, resulting in accumulation of keratotic cellular debris.<\/jats:p>","DOI":"10.5826\/dpc.0403a17","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T19:51:01Z","timestamp":1409687461000},"page":"81-84","source":"Crossref","is-referenced-by-count":5,"title":["\u201cNeglected nipples\u201d: acanthosis nigricans-like plaques caused by avoidance of nipple cleansing"],"prefix":"10.5826","author":[{"given":"Grazyna","family":"Kaminska-Winciore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Wydmanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Scope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Zalaudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2014,7,31]]},"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp0403a17\/dermatol-pract-concept-articleid-dp0403a17-pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp0403a17\/dermatol-pract-concept-articleid-dp0403a17-pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T13:28:40Z","timestamp":1708435720000},"score":1,"resource":{"primary":{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/view\/dermatol-pract-concept-articleid-dp0403a17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,31]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5826\/dpc.0403a17","relation":{},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,31]]}}}