{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:48:48Z","timestamp":1788972528903,"version":"build-2803163510"},"reference-count":0,"publisher":"Mattioli1885","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>Background:\u00a0Differentiation of psoriasis from non-psoriasis psoriasiform dermatitis (NPPD) may be difficult for dermatopathologists, as lack of distinctive histopathological features in a subset of cases may cause confusion in diagnosis.\r\nObjective:\u00a0As the prototype of psoriasiform dermatitis, psoriasis is a hyperproliferative skin disorder with increased epidermal turnover compared with NPPD, we investigated the role of proliferation markers, Ki-67 and Cyclin D1 as diagnostic tools to differentiate psoriasis from other psoriasiform dermatitis.\r\nMethods:\u00a0Histopathological specimens of psoriasis (n = 35) and NPPD (n = 36, 14 pityriasis rubra pilaris, 12 pityriasis rosea and 10 lichen simplex) cases were reviewed and immunohistochemically stained for Ki-67 and Cyclin D1. Ki-67 and Cyclin D1 positive cells were counted for suprabasal, and total epidermal immunostaining per mm2.\r\nResults:\u00a0Suprabasal and total epidermal cell counts for Ki-67 were found to be significantly higher in the psoriasis group compared with the NPPD group (p\u00a0&lt; 0.05). An important and interesting feature was the presence of a cut-off value for the suprabasal\/total epidermal cell count ratio of 75% for Ki-67 immunostaining, which was higher in all patients having psoriasis (range, 77.1% \u2013 92.4%) and lower in all NPPD cases (range, 21.0% \u2013 73.3%). However, suprabasal Cyclin D1 cell counts were higher in the psoriasis group compared with the NPPD group (p\u00a0&lt; 0.05), total epidermal Cyclin D1 cell counts were not statistically significant in either group (p\u00a0= 0.167), and a cut-off value for suprabasal\/total epidermal cell count ratio to distinguish these two entities was not detected using this immunostain.\r\nConclusions:\u00a0We suggest that Ki-67 is a more sensitive marker than Cyclin D1 in terms of having a cut-off value of 75% for the suprabasal\/total epidermal immunoreactive cell count ratio, which we believe could be useful for dermatopathologists in differentiating psoriasis from other psoriasiform dermatitis.\u00a0<\/jats:p>","DOI":"10.5826\/dpc.0503a02","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T15:20:17Z","timestamp":1442244017000},"page":"7-13","source":"Crossref","is-referenced-by-count":26,"title":["Diagnostic utility of Ki-67 and Cyclin D1 immunostaining in differentiation of psoriasis vs. other psoriasiform dermatitis"],"prefix":"10.5826","author":[{"given":"Engin","family":"Sezer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"B\u00f6er-Auer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Tokat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Durmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedef","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umit","family":"Ince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2015,7,31]]},"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp0503a02\/dermatol-pract-concept-articleid-dp0503a02-pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp0503a02\/546","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp0503a02\/dermatol-pract-concept-articleid-dp0503a02-pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T13:24:34Z","timestamp":1708435474000},"score":1,"resource":{"primary":{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/view\/dermatol-pract-concept-articleid-dp0503a02"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5826\/dpc.0503a02","relation":{},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]}}}