{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:23:49Z","timestamp":1788319429143,"version":"build-2803163510"},"reference-count":26,"publisher":"Mattioli1885","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process.\r\nAim: Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunohistochemistry has highlighted true vascular neoplasms, such as microvenular hemangioma, tufted angioma, and spindle cell hemangioma, which has made it helpful to distinguish ALHE from vascular malformations, as there is a negative staining pattern in the other entities. We aimed to investigate the immunoreactivity of ALHE specimens for WT1 as well as glucose transporter protein 1 (GLUT1) immunohistochemistry, an important and sensitive marker for the diagnosis of infantile hemangioma, which recently has been described to label other hemangiomas, such as verrucous hemangioma.\r\nMaterial and methods: Clinical data and histopathological specimens from patients diagnosed with ALHE were reviewed, and immunohistochemical staining and microscopic analysis for WT-1 and GLUT1 were performed.\r\nResults: Intracytoplasmic endothelial staining of WT1 was detected in 19 of 20 ALHE specimens. GLUT1 was not detected in any ALHE specimen.\r\nConclusions: We conclude that ALHE may represent a true hemangioma (i.e., benign vascular neoplasia) characterized by an eosinophil- and lymphocyte-rich inflammatory component as opposed to the reactive inflammatory dermatosis with a positive intracytoplasmic staining pattern for WT1. As far as we are aware, WT1 staining for ALHE has not been described to date.<\/jats:p>","DOI":"10.5826\/dpc.0801a06","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T22:28:36Z","timestamp":1520461716000},"source":"Crossref","is-referenced-by-count":7,"title":["Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia"],"prefix":"10.5826","author":[{"given":"Fatma","family":"Tokat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia S.","family":"Lehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Dikicioglu Cetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"Sezer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umit","family":"Ince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Ozturk Durmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182092527"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31824d2c27"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12123"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02359.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02663.x"},{"key":"ref6","first-page":"1720","article-title":"Tumors of vascular origin.","volume-title":"McKee s Pathology of the Skin","author":"Calonje","year":"2010","unstructured":"6. 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