{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:20:22Z","timestamp":1772626822461,"version":"3.50.1"},"reference-count":0,"publisher":"Mattioli1885","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>Background: Little is known about the dermoscopic evaluation of cutaneous adverse drug reactions (CADRs).\r\nObjectives: To evaluate the dermoscopic patterns of CADRs and identify those associated with severe cutaneous adverse reactions to drugs (SCARDs).\r\nPatients and Methods: Patients included in this study from May 2015 to April 2016 had presented with CADRs. CADR presentation and classification were based on standard criteria. SCARDs included Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), overlap SJS\/TEN, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP). The dermoscopic features of CADRs were described and compared according to the severity of the reactions.\r\nResults: Sixty-nine patients were included. Sixteen patients (23.2%) presented SCARDs. The main dermoscopic findings in SJS, overlap SJS\/TEN and TEN were black dots or necrotic areas (100%). Erosion [respectively, 4\/6 (66.7%), 3\/3 (100%) and 1\/1 (100%)], necrotic borders [respectively, 4\/6 (66.7%), 3\/3 (100%) and 1\/1, (100%)] and epidermal detachment [respectively, 5\/6 (83.3%); 2\/3 (66.7%) and 1\/1 (100%)] were also common among these reactions. Erythema and purpuric dots were the main dermoscopic findings [respectively, 5\/6 (83.3%) and 4\/6 (66.7%)] in DRESS. In non-severe reactions, the most prevalent structures were erythema and purpura in exanthema [respectively, 31\/33 (93.9%) and 24\/33 (72.7%)] and erythema and vascular structures in urticarial reactions [respectively, 6\/6 (100%) and 3\/6 (50%)]. Black dots or necrotic areas, epidermal detachment, necrotic borders and erosion were highly associated with SCARDs (P &lt; 0.001).\r\nConclusions: Dermoscopy improves clinical recognition of SCARDs.<\/jats:p>","DOI":"10.5826\/dpc.1101a136","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T03:50:09Z","timestamp":1611978609000},"page":"e2021136","source":"Crossref","is-referenced-by-count":9,"title":["Dermoscopic Aspects of Cutaneous Adverse Drug Reactions"],"prefix":"10.5826","author":[{"given":"Gabriela","family":"Rossi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Da Silva Cartell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8114-246X","authenticated-orcid":false,"given":"Renato","family":"Marchiori Bakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27750","published-online":{"date-parts":[[2021,1,29]]},"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"https:\/\/www.dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp1101a136\/dp1101a136-pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp1101a136\/dp1101a136-pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T03:50:10Z","timestamp":1611978610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dpcj.org\/index.php\/dpc\/article\/view\/dermatol-pract-concept-articleid-dp1101a136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5826\/dpc.1101a136","relation":{},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,29]]}}}