{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:40:20Z","timestamp":1784799620657,"version":"3.55.0"},"reference-count":0,"publisher":"Mattioli1885","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>Background: Several renal and urinary tract complications have been reported in patients with epidermolysis bullosa.\r\nObjective: This study investigated kidney and urinary tract involvement in patients with epidermolysis bullosa.\r\nPatients and Methods: Patients with epidermolysis bullosa in treatment at the Dermatology Unit were included in the study. Glomerular and tubular functions were investigated.\r\nResults: The study included 16 patients (4 females, 12 males) of mean 11.1 years (SD = 8.1 years). Estimated GFR was normal in all patients except one with end-stage renal disease. Excluding this patient, the urinary albumin\/creatinine ratio and the fractional excretion of sodium were normal. The mean beta-2 microglobulin\/creatinine ratio was 278.8 \u00b5g\/g, and it was abnormally high in 2 patients. The mean tubular phosphorus reabsorption was 92.6%; it was abnormally low in 1 patient. Severe kidney or urinary tract involvement was present in 2 patients with recessive dystrophic EB-generalized severe (RDEB-GS): one patient had obstructive bullous lesions in the urethra; the other had end-stage renal disease secondary to focal segmental glomerulosclerosis and was on peritoneal dialysis for 3 years. \u00a0\r\nConclusions:\u00a0 Assessment for renal and urinary tract involvement should become a routine part of the evaluation of patients with any type of EB, but especially of patients with RDEB-GS. Patients with mild tubular dysfunction need long-term follow-up to detect early deterioration of renal function.<\/jats:p>","DOI":"10.5826\/dpc.1103a51","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T11:02:45Z","timestamp":1625828565000},"page":"2021051","source":"Crossref","is-referenced-by-count":7,"title":["Kidney and Urinary Tract Involvement in Epidermolysis Bullosa: Is Routine Follow-Up Necessary?"],"prefix":"10.5826","author":[{"given":"Neslihan","family":"Cicek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdan","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Asadov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Deniz","family":"Yucelten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Tugtepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harika","family":"Alpay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2021,5,20]]},"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"https:\/\/www.dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp1103a51\/1230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp1103a51\/1243","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dpcj.org\/index.php\/dpc\/article\/download\/dermatol-pract-concept-articleid-dp1103a51\/1230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T11:02:45Z","timestamp":1625828565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dpcj.org\/index.php\/dpc\/article\/view\/dermatol-pract-concept-articleid-dp1103a51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5826\/dpc.1103a51","relation":{},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,20]]}}}