{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T18:42:12Z","timestamp":1732041732028},"reference-count":0,"publisher":"Mattioli1885","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>introduction: IL-15 as a member of the immunoregulatory cytokines family is associated with the development of the autoimmune or chronic inflammatory disease.\u00a0\nobjectives: The goal of this study was to evaluate the serum levels of IL-15 in patients with pemphigus\nvulgaris and assess the association of IL-15 with anti-desmoglein antibodies and the severity of\nthe disease.\nmethods: fifty-three individuals affected with active pemphigus Vulgaris and 38 age and gender-matched healthy controls were enrolled in this study. Clinical characteristics and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) were assessed. Serum levels of IL-15 (pg\/mL) and anti-desmoglein antibodies (Dsg1, 3) were measured.\nResult: The serum level of IL-15 in the patient group was assumed to be statistically higher than\nthat of the control group (3.71 \u00b1 1.5 vs. 0.79 \u00b1 1.03 (p&lt; 0.001)). A positive correlation was found\nbetween serum levels of IL-15 and severity of pemphigus Vulgaris measured by ABSIS (r=0.5,\np=0.04). No significant relationship was detected between the serum level of IL-15 and antidesmoglein antibodies (Dsg1 or Dsg3). (p=0.6 and p=0.9, respectively).\nConclusion: our findings showed that levels of IL\u201015 were elevated in the sera of pemphigus\npatients and were related to disease severity. An increase in serum level of Il-15 in patients with\npemphigus Vulgaris and its relation with disease severity suggest that this cytokine may play a\nrole in the pathogenesis of the disease and targeting IL-15 will likely provide a new\nperspective on the treatment of this disease.<\/jats:p>","DOI":"10.5826\/dpc.1203a118","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T10:02:03Z","timestamp":1659088923000},"page":"e2022118","source":"Crossref","is-referenced-by-count":2,"title":["Elevated Serum Levels of Interleukin-15 in Pemphigus Vulgaris Patients: A Potential Therapeutic Target"],"prefix":"10.5826","author":[{"given":"Maedeh","family":"Kheirodin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Tehranchinia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasaman","family":"Ketabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheil","family":"Tavakolpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Dadkhahfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoomeh","family":"Faghankhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Vahidnezhad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikoo","family":"Mozafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27750","published-online":{"date-parts":[[2022,7,28]]},"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"http:\/\/dpcj.org\/index.php\/dpc\/article\/download\/1965\/1668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/dpcj.org\/index.php\/dpc\/article\/download\/1965\/1668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T10:02:08Z","timestamp":1659175328000},"score":1,"resource":{"primary":{"URL":"http:\/\/dpcj.org\/index.php\/dpc\/article\/view\/1965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5826\/dpc.1203a118","relation":{},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,28]]}}}