{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:52:59Z","timestamp":1783975979343,"version":"3.55.0"},"reference-count":0,"publisher":"Mattioli1885","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>Background: Hidradenitis suppurativa (HS) is a systemic inflammatory disease that extends beyond the skin. The role of gut microbiome alterations in the pathogenesis of inflammatory and autoimmune disorders is remarkable.Objective: Based on the hypothesis that dysbiosis in the gut microbiome may be a trigger for systemic inflammation in the pathogenesis of HS, the aim of this study was to investigate whether the gut microbiome is altered in HS patients comparing with healthy subjects.Methods: In present case-control study, fecal samples from 15 patients with HS and 15 age- and sex-matched healthy individuals were collected and analyzed using 16S rRNA-based metagenomic analysis. The V3 and V4-hypervariable regions of 16S rDNA gene were amplified from all samples and sequenced by the Illumina MiSeq platform. Bioinformatic analyzes were performed in QIIME2. Results: Shannon alpha diversity index showed significantly reduced diversity in HS patients (P = 0.048). Bray-Curtis Dissimilarity and Jaccard Distance revealed that the gut microbial composition of HS patients was significantly distinctive from that of controls (P = 0.01 and P = 0.007, respectively). The relative abundance of unclassified Clostridiales, unclassified Firmicutes and Fusicatenibacter in HS was significantly lower than that in controls (P = 0.005,\u00a0 P = 0.029, and P = 0.046, respectively).Conclusion: This study indicated that significant alterations in gut microbiota of HS patients could play a critical role in the pathogenesis of HS and might be a trigger for systemic inflammation. Increased understanding the pathogenesis of HS will shed light on the new potential therapeutic targets and novel treatment options.<\/jats:p>","DOI":"10.5826\/dpc.1204a191","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T10:35:28Z","timestamp":1667298928000},"page":"e2022191","source":"Crossref","is-referenced-by-count":7,"title":["Alterations of the human gut microbiome in patients with hidradenitis suppurativa: a case-control study and review of the literature"],"prefix":"10.5826","author":[{"given":"Neslihan","family":"Demirel \u00d6\u011f\u00fct","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u015fen","family":"Has\u00e7elik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilg\u00fcn","family":"Atakan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2022,10,31]]},"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/2257\/1784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/2257\/1784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T16:07:55Z","timestamp":1667491675000},"score":1,"resource":{"primary":{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/view\/2257"}},"subtitle":["Gut microbiome in hidradenitis suppurativa"],"short-title":[],"issued":{"date-parts":[[2022,10,31]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5826\/dpc.1204a191","relation":{},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,31]]}}}