{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T07:22:55Z","timestamp":1698823375805},"reference-count":0,"publisher":"Mattioli1885","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>Introduction: Both Androgenetic alopecia (AGA) and age-related macular degeneration (AMD) shared the microinflammatory milieu and increased oxidative stress as important criteria in pathogenesis. \u00a0&#x0D;\nObjectives: To assess the monocyte\/High density lipoprotein (HDL) ratio (MHR) in patients with AGA and its correlation to AMD in these patients, if any.&#x0D;\nMethods: 40 patients with AGA aged 40 years or more of both sexes and 40 control subjects participated in this case-control study. General, dermatological, and ophthalmologic examination, MHR evaluation and optical coherence tomography (OCT) were performed.&#x0D;\nResults: The mean MHR was significantly higher in AGA patients (6.98 \u00b1 2.21) than controls (3.82 \u00b1 0.68) (p&lt;0.001). AMD was significantly higher in patients than control (p &lt;0.001). 80% of patients were diagnosed with AMD vs 20% of control subjects. Presence of AMD in AGA was significantly related to the degree of severity of AGA in male patients (P= 0.02). MHR was significantly higher in AGA patients found to have AMD (9.37 \u00b1 1.1 and 7.01 \u00b1 1.42 in wet and dry type respectively) than those without AMD (P&lt;0.001). The best cutoff value of MHR in prediction of wet type among patients of AGA is \u22658.2337 with overall accuracy 80%. While the best cutoff value of MHR in prediction of dry type among AGA patients is \u22654.1408 to &lt;8.2337 with overall accuracy 86.7%.&#x0D;\nConclusion: AMD may develop more frequently in those with AGA, and this may correspond with the disease's severity. MHR seems to be a missing link between both conditions.<\/jats:p>","DOI":"10.5826\/dpc.1304a285","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:13:48Z","timestamp":1698761628000},"page":"e2023285","source":"Crossref","is-referenced-by-count":0,"title":["Age-Related Macular Degeneration in Patients with Androgenetic Alopecia: Could the Monocyte\/HDL Ratio Be the Link?"],"prefix":"10.5826","author":[{"given":"Ghada","family":"Shams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Abdel-Wahab","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Mohamed","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa Nabil","family":"El-Damaty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira Osama","family":"Abdel-Ghaffar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27750","published-online":{"date-parts":[[2023,10,31]]},"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/3441\/2384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/3441\/2384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:13:48Z","timestamp":1698761628000},"score":1,"resource":{"primary":{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/view\/3441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5826\/dpc.1304a285","relation":{},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,31]]}}}