{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:21:33Z","timestamp":1785781293688,"version":"3.56.0"},"reference-count":0,"publisher":"Mattioli1885","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>Introduction: Scabies is a common disease affecting the pediatric population. Treatment failure and relapses are frequent.\nObjectives: We aimed to define factors affecting topical treatment success in pediatric scabies patients.\nMethods: This multicenter cross-sectional study was performed between April and December 2022. Pediatric scabies cases were classified as treatment failure (TF) versus treatment success (TS).\nResults: We enrolled 170 patients in the study. In the TF group, the presence of symptomatic household members and referral from physicians other than dermatologists were more common (both p&lt;0,001) and relapse rates and total symptom duration were higher (p=0,007, p&lt;0,001 respectively). Permethrin 5% was more commonly used in the TF group (71.1% versus 25%) (p&lt;0,001); however, the ratio of patients treated with sulfur preparations was significantly higher in the TS group (60.7% vs 16.9%) (p&lt;0,001). Misapplication of topical therapy was significantly more common in the TF group (p&lt;0,001), statistically significant errors being: (i) lack of treatment of close contacts (p&lt;0,001); (ii) single application (p&lt;0,001); and (iii) local application (p=0,027). In a multivariate analysis, treatment success was mainly associated with (i) presence of atopy (O.R.: 5,29, 95% CI:\u00a0 1,22-25,57) ;(ii) absence of symptomatic household members (O.R.: 5,29, 95% CI: \u00a01,72-16,27);\u00a0 (iii) presentation to dermatologists rather than other specialties (O.R.: 6,08, 95% CI: 1,9-19,51); whereas use of permethrin negatively affected treatment success (O.R: 0,22, 95% CI: 0,07-0,71).\nConclusions: Pediatric scabies patients should be treated before other family members get affected and with topicals other than permethrin. Awareness of scabies disease needs to be increased among non-dermatologists.<\/jats:p>","DOI":"10.5826\/dpc.1304a307","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:13:37Z","timestamp":1698761617000},"page":"e2023307","source":"Crossref","is-referenced-by-count":6,"title":["Factors Affecting Topical Treatment Success in Pediatric Scabies Cases: A Cross-Sectional Study"],"prefix":"10.5826","author":[{"given":"Muazzez \u00c7i\u011fdem","family":"Oba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defne","family":"\u00d6zkoca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Ba\u015fara \u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem","family":"\u015eenses Kazan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaye","family":"Guldiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beril","family":"Kara Esen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2023,10,31]]},"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/3717\/2368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/3717\/2368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:13:37Z","timestamp":1698761617000},"score":1,"resource":{"primary":{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/view\/3717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5826\/dpc.1304a307","relation":{},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,31]]}}}