{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:37:38Z","timestamp":1770755858011,"version":"3.50.0"},"reference-count":0,"publisher":"Mattioli1885","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Pract Concept"],"abstract":"<jats:p>Introduction\u02d0 The roles of anti-adhesive podocalyxin (PODXL), ant-angiogenetic tumstatin\/Col-IV\u03b13 and neuroinflammation and innate immunity modulator Chitinase 1 (CHIT-1) in the etiology of vitiligo have not been studied yet.\nObjectives: This study was planned to detect changes in serum PODXL, tumstatin\/Col-IV\u03b13 and CHIT1 levels in vitiligo patients.\nMethods: This case-controlled study was performed on a total of 50 patients, 25 with vitiligo and 25 healthy controls. Participants in the vitiligo and control groups were matched in pairs for age and sex. At least 8-10 hours of overnight fasting, venous blood samples were taken from the participants in both groups and serum levels of podocalyxin, tumstatin\/Col-IV\u03b13 and CHIT 1 levels were measured by sandwich enzyme immunoassay.\nResults: In the classification made according to the vitiligo European Task Force evaluation criteria, 18 of 25 vitiligo patients were in the slowly progressive phase and 7 patients were in the active progressive phase. Serum podocalyxin levels increased significantly in the vitiligo group compared to the controls (7.03\u00b12.09 ng\/ml vs. 4.99\u00b11.20 ng\/ml, p&lt;0.02). However, serum tumstatin levels in vitiligo patients showed a significantly lower course compared to controls (4.88\u00b11.76 ng\/ml vs. 6.05\u00b12.19 ng\/nl, p&lt;0.03). Serum CHIT-1 levels of vitiligo patients (42.4\u00b17.22 ng\/ml) were found to be significantly higher than the serum levels of the control group (34.5\u00b15.33 ng\/ml) (p&lt;0.01).\nConclusion: Increased podocalyxin and CHIT1 levels versus decreased tumstatin levels are new biomarkers that support the role of anti-adhesive, anti-angiogenic and neuroinflammatory pathways in the formation of vitiligo.<\/jats:p>","DOI":"10.5826\/dpc.1401a95","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T17:59:53Z","timestamp":1706723993000},"page":"e2024095","source":"Crossref","is-referenced-by-count":1,"title":["Circulating Podocalyxin, Tumstatin\/Col-IV\u03b13 and Chitinase 1: New Culprits in Vitiligo Occurrence"],"prefix":"10.5826","author":[{"given":"\u015eule","family":"Gen\u00e7o\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27750","published-online":{"date-parts":[[2024,1,31]]},"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/3843\/2460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/3843\/2460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T17:59:54Z","timestamp":1706723994000},"score":1,"resource":{"primary":{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/view\/3843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5826\/dpc.1401a95","relation":{},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,31]]}}}