{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:54:08Z","timestamp":1781117648711,"version":"3.54.1"},"reference-count":61,"publisher":"Mattioli1885","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: A systematic review was conducted to investigate the efficacy of acellular fish skin grafts (AFSGs), for the treatment of complicated wounds. AFSGs can be used as a regenerative and antimicrobial tool for healing complicated wounds but clinical evidence remains unclear. Objective: This systematic review aims to summarize the efficacy of AFSGs on complicated wounds using evidence from existing published studies. Methods: Electronic databases like PubMed, ScienceDirect, Google Scholar and Clinicaltrials.gov were searched for relevant literature reporting on the efficacy of AFSGs for wound healing. Based on the inclusion and exclusion criteria, nine studies were selected for data extraction. The quality of the articles was evaluated using the RoB 2 and ROBINS-I tools. Results: Existing evidence shows that AFSGs accelerate wound healing, reduce pain, prevent antibiotic administration and cause no autoimmune reactions. The total reepithelialisation time for diabetic foot ulcers (DFUs) was observed between 15 \u00b1 8 weeks, depending on the severity of the ulcers. Acute biopsy wounds were healed within 3.75 \u00b1 0.25 weeks. AFSGs showed significantly better effects than standard-of-care therapies. However, instances of rashes, erythema, pain, and hypergranulation were reported when AFSGs were applied to biopsy wounds. Conclusion: Overall, the evidence obtained in this systematic review indicates that AFSGs represent a clinically and financially effective option for the treatment of wounds when compared with conventional alternatives.\u00a0<\/jats:p>","DOI":"10.5826\/dpc.1502a4945","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T01:57:20Z","timestamp":1746496640000},"page":"4945","source":"Crossref","is-referenced-by-count":4,"title":["Omega-3 Acellular Fish Skin Grafts for Chronic and Complicated Wounds: A Systematic Review of Efficacy and Safety"],"prefix":"10.5826","volume":"15","author":[{"given":"Mohd. Ashif","family":"Khan","sequence":"first","affiliation":[{"name":"Jamia Hamdard"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Karhana","sequence":"first","affiliation":[{"name":"Jamia Hamdard"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"10.5826\/dpc.1502a4945_ref1","doi-asserted-by":"crossref","unstructured":"R. Thakur, N. Jain, R. Pathak, and S. S. Sandhu, \u201cPractices in wound healing studies of plants,\u201d Evid Based Complement Alternat Med, vol. 2011, 2011, DOI: 10.1155\/2011\/438056.","DOI":"10.1155\/2011\/438056"},{"key":"10.5826\/dpc.1502a4945_ref2","doi-asserted-by":"crossref","unstructured":"C. K. Sen, \u201cHuman Wound and Its Burden: Updated 2020 Compendium of Estimates,\u201d https:\/\/home.liebertpub.com\/wound, vol. 10, no. 5, pp. 281\u2013292, Mar. 2021, DOI: 10.1089\/WOUND.2021.0026.","DOI":"10.1089\/wound.2021.0026"},{"key":"10.5826\/dpc.1502a4945_ref3","doi-asserted-by":"crossref","unstructured":"M. Baba, W. A. Davis, P. E. Norman, and T. M. E. Davis, \u201cTemporal changes in the prevalence and associates of foot ulceration in type 2 diabetes: The Fremantle Diabetes Study,\u201d J Diabetes Complications, vol. 29, no. 3, pp. 356\u2013361, Apr. 2015, DOI: 10.1016\/J.JDIACOMP.2015.01.008.","DOI":"10.1016\/j.jdiacomp.2015.01.008"},{"key":"10.5826\/dpc.1502a4945_ref4","unstructured":"D. G. ARMSTRONG, null D.P.M., and L. A. LAVERY, \u201cDiabetic Foot Ulcers: Prevention, Diagnosis and Classification,\u201d Am Fam Physician, vol. 57, no. 6, pp. 1325\u20131332, Mar. 1998, Accessed: Nov. 17, 2022. [Online]. Available: https:\/\/www.aafp.org\/pubs\/afp\/issues\/1998\/0315\/p1325.html"},{"key":"10.5826\/dpc.1502a4945_ref5","doi-asserted-by":"crossref","unstructured":"M. \u00c1. Tresierra-Ayala and A. Garc\u00eda Rojas, \u201cAssociation between peripheral arterial disease and diabetic foot ulcers in patients with diabetes mellitus type 2,\u201d Medicina Universitaria, vol. 19, no. 76, pp. 123\u2013126, Jul. 2017, DOI: 10.1016\/J.RMU.2017.07.002.","DOI":"10.1016\/j.rmu.2017.07.002"},{"key":"10.5826\/dpc.1502a4945_ref6","doi-asserted-by":"crossref","unstructured":"M. Asaf, N. Salim, M. Tuffaha, and N. A. Salim, \u201cChallenging the Use of Bandage Compression as the Baseline for Evaluating the Healing Outcomes of Venous Leg Ulcer-Related Compression Therapies in the Community and Outpatient Setting: An Integrative Review,\u201d Dubai Medical Journal, vol. 1, no. 1\u20134, pp. 19\u201325, Nov. 2018, DOI: 10.1159\/000494217.","DOI":"10.1159\/000494217"},{"key":"10.5826\/dpc.1502a4945_ref7","doi-asserted-by":"crossref","unstructured":"J. Spiliotis et al., \u201cWound dehiscence: is still a problem in the 21th century: a retrospective study,\u201d World Journal of Emergency Surgery, vol. 4, no. 1, p. 12, 2009, DOI: 10.1186\/1749-7922-4-12.","DOI":"10.1186\/1749-7922-4-12"},{"key":"10.5826\/dpc.1502a4945_ref8","doi-asserted-by":"crossref","unstructured":"V. K. Shukla, M. A. Ansari, and S. K. Gupta, \u201cWound healing research: A perspective from India,\u201d International Journal of Lower Extremity Wounds, vol. 4, no. 1, pp. 7\u20138, Mar. 2005, DOI: 10.1177\/1534734604273660.","DOI":"10.1177\/1534734604273660"},{"key":"10.5826\/dpc.1502a4945_ref9","doi-asserted-by":"crossref","unstructured":"A. P. Veith, K. Henderson, A. Spencer, A. D. Sligar, and A. B. Baker, \u201cTherapeutic strategies for enhancing angiogenesis in wound healing,\u201d Adv Drug Deliv Rev, vol. 146, pp. 97\u2013125, Jun. 2019, DOI: 10.1016\/j.addr.2018.09.010.","DOI":"10.1016\/j.addr.2018.09.010"},{"key":"10.5826\/dpc.1502a4945_ref10","doi-asserted-by":"crossref","unstructured":"Y. Niu, Q. Li, Y. Ding, L. Dong, and C. Wang, \u201cEngineered delivery strategies for enhanced control of growth factor activities in wound healing,\u201d Adv Drug Deliv Rev, vol. 146, pp. 190\u2013208, Jun. 2019, DOI: 10.1016\/j.addr.2018.06.002.","DOI":"10.1016\/j.addr.2018.06.002"},{"key":"10.5826\/dpc.1502a4945_ref11","doi-asserted-by":"crossref","unstructured":"E. M. Tottoli, R. Dorati, I. Genta, E. Chiesa, S. Pisani, and B. Conti, \u201cSkin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration,\u201d Pharmaceutics, vol. 12, no. 8, p. 735, Aug. 2020, DOI: 10.3390\/pharmaceutics12080735.","DOI":"10.3390\/pharmaceutics12080735"},{"key":"10.5826\/dpc.1502a4945_ref12","doi-asserted-by":"crossref","unstructured":"S. Jacobsen, \u201cTopical Wound Treatments and Wound\u2010Care Products,\u201d in Equine Wound Management, Wiley, 2016, pp. 75\u2013103. DOI: 10.1002\/9781118999219.ch5.","DOI":"10.1002\/9781118999219.ch5"},{"key":"10.5826\/dpc.1502a4945_ref13","doi-asserted-by":"crossref","unstructured":"K. Barrigah-Benissan, J. Ory, A. Sotto, F. Salipante, J.-P. Lavigne, and P. Loubet, \u201cAntiseptic Agents for Chronic Wounds: A Systematic Review,\u201d Antibiotics, vol. 11, no. 3, p. 350, Mar. 2022, DOI: 10.3390\/antibiotics11030350.","DOI":"10.3390\/antibiotics11030350"},{"key":"10.5826\/dpc.1502a4945_ref14","doi-asserted-by":"crossref","unstructured":"M. Abd Elhakeem, N. Zaher, A. Ezzat, A. Ashraf, and O. Seif, \u201cMethacrylate Powder Dressing in Traumatic, Pressure sore, Venous ulcers and Burn Wounds Healing,\u201d Benha Medical Journal, vol. 0, no. 0, pp. 0\u20130, Aug. 2022, DOI: 10.21608\/bmfj.2022.128226.1560.","DOI":"10.21608\/bmfj.2022.128226.1560"},{"key":"10.5826\/dpc.1502a4945_ref15","doi-asserted-by":"crossref","unstructured":"S. A. Chowdhry, \u201cUse of oxidized regenerated cellulose (ORC)\/collagen\/silver-ORC dressings to help manage skin graft donor site wounds,\u201d JPRAS Open, vol. 22, pp. 33\u201340, Dec. 2019, DOI: 10.1016\/j.jpra.2019.08.001.","DOI":"10.1016\/j.jpra.2019.08.001"},{"key":"10.5826\/dpc.1502a4945_ref16","doi-asserted-by":"crossref","unstructured":"E. B. Jude, J. Apelqvist, M. Spraul, and J. Martini, \u201cProspective randomized controlled study of Hydrofiber\u00ae dressing containing ionic silver or calcium alginate dressings in non\u2010ischaemic diabetic foot ulcers,\u201d Diabetic Medicine, vol. 24, no. 3, pp. 280\u2013288, Mar. 2007, DOI: 10.1111\/j.1464-5491.2007.02079.x.","DOI":"10.1111\/j.1464-5491.2007.02079.x"},{"key":"10.5826\/dpc.1502a4945_ref17","doi-asserted-by":"crossref","unstructured":"P. Muangman, C. Pundee, S. Opasanon, and S. Muangman, \u201cA prospective, randomized trial of silver containing hydrofiber dressing versus 1% silver sulfadiazine for the treatment of partial thickness burns,\u201d Int Wound J, vol. 7, no. 4, pp. 271\u2013276, Aug. 2010, DOI: 10.1111\/j.1742-481X.2010.00690.x.","DOI":"10.1111\/j.1742-481X.2010.00690.x"},{"key":"10.5826\/dpc.1502a4945_ref18","doi-asserted-by":"crossref","unstructured":"R. G. Frykberg and J. Banks, \u201cChallenges in the Treatment of Chronic Wounds,\u201d Adv Wound Care (New Rochelle), vol. 4, no. 9, pp. 560\u2013582, Sep. 2015, DOI: 10.1089\/wound.2015.0635.","DOI":"10.1089\/wound.2015.0635"},{"key":"10.5826\/dpc.1502a4945_ref19","doi-asserted-by":"crossref","unstructured":"D.-C. Ding, Y.-H. Chang, W.-C. Shyu, and S.-Z. Lin, \u201cHuman Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy,\u201d Cell Transplant, vol. 24, no. 3, pp. 339\u2013347, Mar. 2015, DOI: 10.3727\/096368915X686841.","DOI":"10.3727\/096368915X686841"},{"key":"10.5826\/dpc.1502a4945_ref20","doi-asserted-by":"crossref","unstructured":"N. Kosaric, H. Kiwanuka, and G. C. Gurtner, \u201cStem cell therapies for wound healing,\u201d Expert Opin Biol Ther, vol. 19, no. 6, pp. 575\u2013585, Jun. 2019, DOI: 10.1080\/14712598.2019.1596257.","DOI":"10.1080\/14712598.2019.1596257"},{"key":"10.5826\/dpc.1502a4945_ref21","unstructured":"\u201cAcellular Dermal Matrix (ADM) Products Used in Implant-Based Breast Reconstruction Differ in Complication Rates: FDA Safety Communication | FDA.\u201d Accessed: Nov. 18, 2022. [Online]. Available: https:\/\/www.fda.gov\/medical-devices\/safety-communications\/acellular-dermal-matrix-adm-products-used-implant-based-breast-reconstruction-differ-complication"},{"key":"10.5826\/dpc.1502a4945_ref22","doi-asserted-by":"crossref","unstructured":"C. V. Ellis and D. A. Kulber, \u201cAcellular Dermal Matrices in Hand Reconstruction,\u201d Plast Reconstr Surg, vol. 130, pp. 256S-269S, Nov. 2012, DOI: 10.1097\/PRS.0b013e318265a5cf.","DOI":"10.1097\/PRS.0b013e318265a5cf"},{"key":"10.5826\/dpc.1502a4945_ref23","doi-asserted-by":"crossref","unstructured":"A. Pabst et al., \u201cBiomechanical Characterization of a New Acellular Dermal Matrix for Oral Soft Tissue Regeneration,\u201d Journal of Investigative Surgery, vol. 35, no. 6, pp. 1296\u20131303, Jun. 2022, DOI: 10.1080\/08941939.2022.2047245.","DOI":"10.1080\/08941939.2022.2047245"},{"key":"10.5826\/dpc.1502a4945_ref24","doi-asserted-by":"crossref","unstructured":"T. H. Kim, J. H. Park, H. G. Jeong, and S. Y. Wee, \u201cThe Utility of Novel Fish-Skin Derived Acellular Dermal Matrix (Kerecis) as a Wound Dressing Material,\u201d Journal of Wound Management and Research, vol. 17, no. 1, pp. 39\u201347, Feb. 2021, DOI: 10.22467\/JWMR.2020.01228.","DOI":"10.22467\/jwmr.2020.01228"},{"key":"10.5826\/dpc.1502a4945_ref25","unstructured":"T. O\u2019Donnell, M. Passman, \u2026 W. M.-J. of vascular, and undefined 2014, \u201cManagement of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery\u00ae and the American Venous Forum,\u201d jvascsurg.org, Accessed: Nov. 18, 2022. [Online]. Available: https:\/\/www.jvascsurg.org\/article\/S0741-5214(14)00851-9\/abstract"},{"key":"10.5826\/dpc.1502a4945_ref26","doi-asserted-by":"crossref","unstructured":"S. Rakers et al., \u201c\u2018Fish matters\u2019: the relevance of fish skin biology to investigative dermatology,\u201d Exp Dermatol, vol. 19, no. 4, pp. 313\u2013324, Apr. 2010, DOI: 10.1111\/j.1600-0625.2009.01059.x.","DOI":"10.1111\/j.1600-0625.2009.01059.x"},{"key":"10.5826\/dpc.1502a4945_ref27","doi-asserted-by":"crossref","unstructured":"M. Sun, J. Dong, Y. Xia, and R. Shu, \u201cAntibacterial activities of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against planktonic and biofilm growing Streptococcus mutans,\u201d Microb Pathog, vol. 107, pp. 212\u2013218, Jun. 2017, DOI: 10.1016\/j.micpath.2017.03.040.","DOI":"10.1016\/j.micpath.2017.03.040"},{"key":"10.5826\/dpc.1502a4945_ref28","doi-asserted-by":"crossref","unstructured":"M. Sun, Z. Zhou, J. Dong, J. Zhang, Y. Xia, and R. Shu, \u201cAntibacterial and antibiofilm activities of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against periodontopathic bacteria,\u201d Microb Pathog, vol. 99, pp. 196\u2013203, Oct. 2016, DOI: 10.1016\/j.micpath.2016.08.025.","DOI":"10.1016\/j.micpath.2016.08.025"},{"key":"10.5826\/dpc.1502a4945_ref29","doi-asserted-by":"crossref","unstructured":"F. Bassetto, C. Scarpa, and F. Facchin, \u201cComplicated Wounds,\u201d in Textbook of Plastic and Reconstructive Surgery, Cham: Springer International Publishing, 2022, pp. 27\u201338. DOI: 10.1007\/978-3-030-82335-1_3.","DOI":"10.1007\/978-3-030-82335-1_3"},{"key":"10.5826\/dpc.1502a4945_ref30","doi-asserted-by":"crossref","unstructured":"M. L. B. S\u00f8rensen, R. B. Jansen, T. Wilbek Fabricius, B. J\u00f8rgensen, and O. L. Svendsen, \u201cHealing of Diabetic Foot Ulcers in Patients Treated at the Copenhagen Wound Healing Center in 1999\/2000 and in 2011\/2012,\u201d J Diabetes Res, vol. 2019, pp. 1\u20139, Sep. 2019, DOI: 10.1155\/2019\/6429575.","DOI":"10.1155\/2019\/6429575"},{"key":"10.5826\/dpc.1502a4945_ref31","doi-asserted-by":"crossref","unstructured":"A. C. Yelland et al., \u201cImpact of case\u2010mix adjustment on observed variation in the healing of diabetic foot ulcers at 12 weeks using data from the National Diabetes Foot Care Audit of England and Wales: A cohort study,\u201d Diabetic Medicine, vol. 40, no. 1, Jan. 2023, DOI: 10.1111\/dme.14959.","DOI":"10.1111\/dme.14959"},{"key":"10.5826\/dpc.1502a4945_ref32","doi-asserted-by":"crossref","unstructured":"T. Zehnder and M. Blatti, \u201cFaster Than Projected Healing in Chronic Venous and Diabetic Foot Ulcers When Treated with Intact Fish Skin Grafts Compared to Expected Healing Times for Standard of Care: An Outcome-Based Model from a Swiss Hospital,\u201d International Journal of Lower Extremity Wounds, 2022, DOI: 10.1177\/15347346221096205.","DOI":"10.1177\/15347346221096205"},{"key":"10.5826\/dpc.1502a4945_ref33","doi-asserted-by":"crossref","unstructured":"B. Dorweiler et al., \u201cThe marine Omega3 wound matrix for treatment of complicated wounds: A multicenter experience report,\u201d Gefasschirurgie, vol. 23, pp. 46\u201355, Aug. 2018, DOI: 10.1007\/S00772-018-0428-2.","DOI":"10.1007\/s00772-018-0428-2"},{"key":"10.5826\/dpc.1502a4945_ref34","doi-asserted-by":"crossref","unstructured":"A. E. Rivera and J. M. Spencer, \u201cClinical aspects of full-thickness wound healing,\u201d Clin Dermatol, vol. 25, no. 1, pp. 39\u201348, Jan. 2007, DOI: 10.1016\/j.clindermatol.2006.10.001.","DOI":"10.1016\/j.clindermatol.2006.10.001"},{"key":"10.5826\/dpc.1502a4945_ref35","doi-asserted-by":"crossref","unstructured":"T. Woodrow, T. Chant, and H. Chant, \u201cTreatment of diabetic foot wounds with acellular fish skin graft rich in omega-3: a prospective evaluation,\u201d https:\/\/DOI.org\/10.12968\/jowc.2019.28.2.76, vol. 28, no. 2, pp. 76\u201380, Feb. 2019, DOI: 10.12968\/JOWC.2019.28.2.76.","DOI":"10.12968\/jowc.2019.28.2.76"},{"key":"10.5826\/dpc.1502a4945_ref36","doi-asserted-by":"crossref","unstructured":"E. Lullove, B. Liden, \u2026 P. M.-\u2026 : a C. of, and undefined 2022, \u201cEvaluating the effect of omega-3-rich fish skin in the treatment of chronic, nonresponsive diabetic foot ulcers: penultimate analysis of a multicenter, prospective,\u201d europepmc.org, Accessed: Nov. 29, 2022. [Online]. Available: https:\/\/europepmc.org\/article\/med\/35797557","DOI":"10.25270\/wnds\/2022.e34e36"},{"key":"10.5826\/dpc.1502a4945_ref37","doi-asserted-by":"crossref","unstructured":"R. S. Kirsner et al., \u201cFish skin grafts compared to human amnion\/chorion membrane allografts: A double\u2010blind, prospective, randomized clinical trial of acute wound healing,\u201d Wiley Online Library, vol. 28, no. 1, pp. 75\u201380, Jan. 2019, DOI: 10.1111\/wrr.12761.","DOI":"10.1111\/wrr.12761"},{"key":"10.5826\/dpc.1502a4945_ref38","doi-asserted-by":"crossref","unstructured":"B. T. Baldursson, H. Kjartansson, F. Konr\u00e1dsd\u00f3ttir, P. Gudnason, G. F. Sigurjonsson, and S. H. Lund, \u201cHealing rate and autoimmune safety of full-thickness wounds treated with fish skin acellular dermal matrix versus porcine small-intestine submucosa: A noninferiority study,\u201d International Journal of Lower Extremity Wounds, vol. 14, no. 1, pp. 37\u201343, Mar. 2015, DOI: 10.1177\/1534734615573661.","DOI":"10.1177\/1534734615573661"},{"key":"10.5826\/dpc.1502a4945_ref39","doi-asserted-by":"crossref","unstructured":"J. Yoon et al., \u201cWound healing ability of acellular fish skin and bovine collagen grafts for split-thickness donor sites in burn patients: Characterization of acellular grafts and clinical,\u201d Elsevier, Accessed: Nov. 29, 2022. [Online]. Available: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0141813022002914","DOI":"10.1016\/j.ijbiomac.2022.02.055"},{"key":"10.5826\/dpc.1502a4945_ref40","doi-asserted-by":"crossref","unstructured":"H. Luze, S. P. Nischwitz, C. Smolle, R. Zrim, and L.-P. Kamolz, \u201cThe Use of Acellular Fish Skin Grafts in Burn Wound Management\u2014A Systematic Review,\u201d Medicina (B Aires), vol. 58, no. 7, p. 912, Jul. 2022, DOI: 10.3390\/medicina58070912.","DOI":"10.3390\/medicina58070912"},{"key":"10.5826\/dpc.1502a4945_ref41","doi-asserted-by":"crossref","unstructured":"S. Magnusson et al., \u201cAcellular Fish Skin Grafts and Pig Urinary Bladder Matrix Assessed in the Collagen-Induced Arthritis Mouse Model,\u201d Int J Low Extrem Wounds, vol. 17, no. 4, pp. 275\u2013281, Dec. 2018, DOI: 10.1177\/1534734618802899.","DOI":"10.1177\/1534734618802899"},{"key":"10.5826\/dpc.1502a4945_ref42","doi-asserted-by":"crossref","unstructured":"E. S. Mauer, E. A. Maxwell, C. J. Cocca, J. Ganjei, and D. Spector, \u201cAcellular fish skin grafts for the management of wounds in dogs and cats: 17 cases (2019\u20132021),\u201d Am J Vet Res, vol. 83, no. 2, pp. 188\u2013192, Feb. 2022, DOI: 10.2460\/ajvr.21.09.0140.","DOI":"10.2460\/ajvr.21.09.0140"},{"key":"10.5826\/dpc.1502a4945_ref43","doi-asserted-by":"crossref","unstructured":"A. de Souza et al., \u201cFish collagen for skin wound healing: a systematic review in experimental animal studies,\u201d Cell Tissue Res, vol. 388, no. 3, pp. 489\u2013502, Jun. 2022, DOI: 10.1007\/s00441-022-03625-w.","DOI":"10.1007\/s00441-022-03625-w"},{"key":"10.5826\/dpc.1502a4945_ref44","doi-asserted-by":"crossref","unstructured":"D. Li et al., \u201cEvaluation of a novel tilapia-skin acellular dermis matrix rationally processed for enhanced wound healing,\u201d Materials Science and Engineering: C, vol. 127, p. 112202, Aug. 2021, DOI: 10.1016\/j.msec.2021.112202.","DOI":"10.1016\/j.msec.2021.112202"},{"key":"10.5826\/dpc.1502a4945_ref45","doi-asserted-by":"crossref","unstructured":"K. Lv, L. Wang, X. He, W. Li, L. Han, and S. Qin, \u201cApplication of Tilapia Skin Acellular Dermal Matrix to Induce Acute Skin Wound Repair in Rats,\u201d Front Bioeng Biotechnol, vol. 9, Feb. 2022, DOI: 10.3389\/fbioe.2021.792344.","DOI":"10.3389\/fbioe.2021.792344"},{"key":"10.5826\/dpc.1502a4945_ref46","unstructured":"C. Winters, C. is P.-D. F. J, and undefined 2018, \u201cWound dehiscence on a diabetic patient with hemophilia and high risk of further amputation successfully healed with omega 3 rich fish skin: a case report,\u201d diabetesonthenet.com, vol. 21, no. 3, 2018, Accessed: Dec. 01, 2022. [Online]. Available: https:\/\/diabetesonthenet.com\/wp-content\/uploads\/pdf\/dotn5af79c6d5de192c212a36c077c19189a.pdf"},{"key":"10.5826\/dpc.1502a4945_ref47","doi-asserted-by":"crossref","unstructured":"K. Alam and S. L. A. Jeffery, \u201cAcellular Fish Skin Grafts for Management of Split Thickness Donor Sites and Partial Thickness Burns: A Case Series,\u201d Mil Med, vol. 184, no. Supplement_1, pp. 16\u201320, Mar. 2019, DOI: 10.1093\/MILMED\/USY280.","DOI":"10.1093\/milmed\/usy280"},{"key":"10.5826\/dpc.1502a4945_ref48","doi-asserted-by":"crossref","unstructured":"C. Daidone, N. Salim, L. Smith, and A. Raza, \u201cThe Role of Fish Skin Xenografts in Healing Complex Wounds: A Brief Case Report,\u201d Cureus, Mar. 2024, DOI: 10.7759\/cureus.56156.","DOI":"10.7759\/cureus.56156"},{"key":"10.5826\/dpc.1502a4945_ref49","doi-asserted-by":"crossref","unstructured":"latifi Rifat and Abbas Smiley, \u201cacellelar fish skin garft use in open abdomen management,\u201d Surgical Technology Internationsl, vol. 42, 2023.","DOI":"10.52198\/23.STI.42.GS1705"},{"key":"10.5826\/dpc.1502a4945_ref50","doi-asserted-by":"crossref","unstructured":"D. le Guellec, G. Morvan-Dubois, J. S.-I. J. of, and undefined 2003, \u201cSkin development in bony fish with particular emphasis on collagen deposition in the dermis of the zebrafish (Danio rerio).,\u201d ijdb.ehu.es, vol. 48, pp. 217\u2013231, 2004, Accessed: Dec. 01, 2022. [Online]. Available: http:\/\/www.ijdb.ehu.es\/web\/paper\/15272388\/skin-development-in-bony-fish-with-particular-emphasis-on-collagen-deposition-in-the-dermis-of-the-zebrafish-danio-rerio","DOI":"10.1387\/ijdb.15272388"},{"key":"10.5826\/dpc.1502a4945_ref51","doi-asserted-by":"crossref","unstructured":"S. R. Van Doren, \u201cMatrix metalloproteinase interactions with collagen and elastin,\u201d Matrix Biology, vol. 44\u201346, pp. 224\u2013231, May 2015, DOI: 10.1016\/j.matbio.2015.01.005.","DOI":"10.1016\/j.matbio.2015.01.005"},{"key":"10.5826\/dpc.1502a4945_ref52","doi-asserted-by":"crossref","unstructured":"J. C. McDaniel, K. Massey, and A. Nicolaou, \u201cFish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds,\u201d Wound Repair and Regeneration, vol. 19, no. 2, pp. 189\u2013200, Mar. 2011, DOI: 10.1111\/j.1524-475X.2010.00659.x.","DOI":"10.1111\/j.1524-475X.2010.00659.x"},{"key":"10.5826\/dpc.1502a4945_ref53","doi-asserted-by":"crossref","unstructured":"S. Magnusson, B. Baldursson, \u2026 H. K.-M., and undefined 2017, \u201cRegenerative and antibacterial properties of acellular fish skin grafts and human amnion\/chorion membrane: implications for tissue preservation in combat casualty,\u201d academic.oup.com, Accessed: Dec. 01, 2022. [Online]. Available: https:\/\/academic.oup.com\/milmed\/article-abstract\/182\/suppl_1\/383\/4209412","DOI":"10.7205\/MILMED-D-16-00142"},{"key":"10.5826\/dpc.1502a4945_ref54","unstructured":"E. Lima-Junior, N. Picollo, and M. Miranda, \u201cUso da pele de til\u00e1pia (Oreochromis niloticus), como curativo biol\u00f3gico oclusivo, no tratamento de queimaduras,\u201d Rev Bras Queimaduras, vol. 16, no. 1, pp. 10\u201317, 2017, Accessed: Dec. 01, 2022. [Online]. Available: https:\/\/repositorio.ufc.br\/handle\/riufc\/28917"},{"key":"10.5826\/dpc.1502a4945_ref55","doi-asserted-by":"crossref","unstructured":"P. Brown, R. G. Will, R. Bradley, D. M. Asher, and L. Detwiler, \u201cBovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: background, evolution, and current concerns.,\u201d Emerg Infect Dis, vol. 7, no. 1, p. 6, 2001, DOI: 10.3201\/EID0701.010102.","DOI":"10.3201\/eid0701.010102"},{"key":"10.5826\/dpc.1502a4945_ref56","unstructured":"H. Kjartansson, I. Olafsson, \u2026 S. K.-O. J. of M., and undefined 2015, \u201cUse of acellular fish skin for dura repair in an ovine model: a pilot study,\u201d scirp.org, Accessed: Dec. 01, 2022. [Online]. Available: https:\/\/www.scirp.org\/html\/4-2080131_60730.htm"},{"key":"10.5826\/dpc.1502a4945_ref57","unstructured":"C. Winters, R. S. Kirsner, D. J. Margolis, and J. C. Lantis, \u201cCost Effectiveness of Fish Skin Grafts Versus Standard of Care on Wound Healing of Chronic Diabetic Foot Ulcers: A Retrospective Comparative Cohort Study.,\u201d Wounds, vol. 32, no. 10, pp. 283\u2013290, Oct. 2020."},{"key":"10.5826\/dpc.1502a4945_ref58","doi-asserted-by":"crossref","unstructured":"S. Karhana, S. Dabral, A. Garg, A. Bano, N. Agarwal, and Mohd. A. Khan, \u201cNetwork pharmacology and molecular docking analysis on potential molecular targets and mechanism of action of BRAF inhibitors for application in wound healing,\u201d J Cell Biochem, vol. 124, no. 7, pp. 1023\u20131039, Jul. 2023, DOI: 10.1002\/jcb.30430.","DOI":"10.1002\/jcb.30430"},{"key":"10.5826\/dpc.1502a4945_ref59","doi-asserted-by":"crossref","unstructured":"A. Garg et al., \u201cNetwork pharmacology and molecular docking study-based approach to explore mechanism of benzimidazole-based anthelmintics for the treatment of lung cancer,\u201d J Biomol Struct Dyn, pp. 1\u201322, Sep. 2023, DOI: 10.1080\/07391102.2023.2258419.","DOI":"10.1080\/07391102.2023.2258419"},{"key":"10.5826\/dpc.1502a4945_ref60","doi-asserted-by":"crossref","unstructured":"X. Zhang et al., \u201cCurrent Progress and Outlook of Nano-Based Hydrogel Dressings for Wound Healing,\u201d Pharmaceutics, vol. 15, no. 1, p. 68, Dec. 2022, DOI: 10.3390\/pharmaceutics15010068.","DOI":"10.3390\/pharmaceutics15010068"},{"key":"10.5826\/dpc.1502a4945_ref61","doi-asserted-by":"crossref","unstructured":"N. Kosaric, H. Kiwanuka, and G. C. Gurtner, \u201cStem cell therapies for wound healing,\u201d Expert Opin Biol Ther, vol. 19, no. 6, pp. 575\u2013585, Jun. 2019, DOI: 10.1080\/14712598.2019.1596257.","DOI":"10.1080\/14712598.2019.1596257"}],"container-title":["Dermatology Practical &amp; Conceptual"],"original-title":[],"link":[{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/4945\/3092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/4945\/3492","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/download\/4945\/3091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:43:21Z","timestamp":1762523001000},"score":1,"resource":{"primary":{"URL":"https:\/\/dpcj.org\/index.php\/dpc\/article\/view\/4945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":61,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5826\/dpc.1502a4945","relation":{"has-manifestation":[{"id-type":"other","id":"1-79-4945-g3091","asserted-by":"subject"},{"id-type":"other","id":"1-79-4945-g3092","asserted-by":"subject"},{"id-type":"other","id":"1-79-4945-g3492","asserted-by":"subject"}],"is-part-of":[{"id-type":"doi","id":"10.5826\/dpc.v15i2","asserted-by":"subject"}]},"ISSN":["2160-9381"],"issn-type":[{"value":"2160-9381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]},"article-number":"4"}}