{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:28:12Z","timestamp":1793330892126,"version":"4.5.0"},"reference-count":32,"publisher":"Mattioli1885","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Scabies is a parasitic infectious skin disease classified as a neglected tropical disease by the World Health Organization in 2017. Currently, it is becoming a major challenge in high-income countries, with rapidly rising incidence and increasing reports about treatment failure. Objectives: Factors that are associated with treatment failure or success were evaluated. Methods: This non-interventional prospective observational study was conducted as a questionnaire survey at the Department of Dermatology and Venereology of the University of Freiburg from January to November 2023. Patients that still suffered from scabies 2\u20136 weeks after medical treatment were classified as \u201cfailure\u201d; those who were free of scabies belonged to the success group. Results: Of 102 participants, with a mean age of 34.4 \u00b1 17.3 years (male: 60.4%), 77 (75.5%) were assigned to the success and 25 (24.5%) to the failure group. A larger proportion of the latter was clinically more severely affected, applied permethrin monotherapy, did not undertake special decontamination measures, but used alcohol as a disinfectant. Treatment success was associated with an additional systemic treatment, a repeated intake of ivermectin, and intensified decontamination measures such as storage of clothes in plastic bags for four days or vacuum cleaning of car seats. Conclusions: Our findings indicate that a consistent second-dose administration of ivermectin and refraining from permethrin monotherapy may be advisable.<\/jats:p>","DOI":"10.5826\/dpc.1502a5077","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:03:16Z","timestamp":1747202596000},"page":"5077","source":"Crossref","is-referenced-by-count":8,"title":["Scabies Management Outcomes: Identification of Risk Factors for Treatment Success or Failure"],"prefix":"10.5826","volume":"15","author":[{"given":"Vanessa","family":"Azzolina","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Schauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Felicitas","family":"Pilz","sequence":"additional","affiliation":[{"name":"Technical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zink","sequence":"additional","affiliation":[{"name":"Technical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian","family":"Eyerich","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Pilz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"10.5826\/dpc.1502a5077_ref1","doi-asserted-by":"crossref","unstructured":"Engelman D, Cantey PT, Marks M, et al. 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