{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:33:04Z","timestamp":1769131984417,"version":"3.49.0"},"reference-count":30,"publisher":"Mattioli1885","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Atopic dermatitis (AD) is an inflammatory chronic condition associated with a significant physical, psychological, and economic burden. Objective: This study aims to determine the multidimensional impact of atopic dermatitis (AD) on patients and the Spanish healthcare system. Methods: The APOLO is a multicenter, descriptive, cross-sectional study conducted at 12 Spanish sites, in which participants completed a series of scales and questionnaires. Results: Of 62 patients included (54.8% men; mean [standard deviation] age: 33.1 [12.8] years), 61.3% and 38.7% had moderate and severe AD, respectively (validated Investigator Global Assessment scale for AD). AD affected a mean of 43.3% (22.1) of the body surface, and patients reported a median (interquartile range) of 4.0 (2.0-10.0) flares in the previous year. The mean Patient-Oriented Eczema Measure (POEM) score was 19.8 (6.4), indicating a severe eczema stage. Additionally, 57.1% of patients experienced pain daily due to scratching or skin inflammation. The Dermatology Life Quality Index (DLQI) showed a strong AD impact on patients\u2019 quality of life (mean DLQI=14.3 [7.6]), positively correlated with severity, pruritus, and pain. AD also affected patients\u2019 work\/academic activities and sleep. The disease was mostly treated with topical corticosteroids (81.5%) and emollients (75.9%). In the prior year, no patient required hospitalization; and 25% of patients resorted to alternative therapies\/unlicensed products. Conclusions: AD profoundly impacts patients\u2019 quality of life and entails high economic costs. This study emphasizes the need for more effective treatment strategies and an improved understanding of the AD burden to utilize public healthcare resources more efficiently.<\/jats:p>","DOI":"10.5826\/dpc.1503a5538","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T13:04:12Z","timestamp":1752757452000},"page":"5538","source":"Crossref","is-referenced-by-count":3,"title":["Patient Burden And Impact Of Moderate-to-Severe Atopic Dermatitis In the Spanish Healthcare System: The APOLO Cross-Sectional Study"],"prefix":"10.5826","volume":"15","author":[{"given":"Pablo","family":"De La Cueva Dobao","sequence":"first","affiliation":[{"name":"Hospital Universitario Infanta Leonor - Gran V\u00eda del Este, 80, 28031 Madrid"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Curto Barredo","sequence":"additional","affiliation":[{"name":"Hospital del Mar - Pg. Mar\u00edtim de la Barceloneta, 25, 29, Ciutat Vella, 08003 Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Francisco","family":"Silvestre Salvador","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Dr. Balmis - C\/Pintor Baeza, 11, 03010 Alicante"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Serra Baldrich","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau - C\/Sant Quint\u00ed, 89, Horta-Guinard\u00f3, 08025 Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Herranz Pinto","sequence":"additional","affiliation":[{"name":"Dermatology department, La Paz University Hospital; Autonomous University of Madrid - P.\u00ba de la Castellana, 261, Fuencarral-El Pardo, 28046 Madrid"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Hern\u00e1ndez Cano","sequence":"additional","affiliation":[{"name":"Dermatology department, La Paz University Hospital; Autonomous University of Madrid - P.\u00ba de la Castellana, 261, Fuencarral-El Pardo, 28046 Madrid"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Ortiz De Frutos","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre - Av. De C\u00f3rdoba s\/n, Usera, 28041 Madrid"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gast\u00f3n","family":"Roustan Gull\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro - C\/Joaqu\u00edn Rodrigo, 1, 28222 Majadahonda (Madrid)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Mar\u00eda","family":"Izu Belloso","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Basurto - Montevideo Etorb., 18, Basurtu-Zorrotza, 48013 Bilbo, (Bizkaia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Ar\u00e9valo Ortega","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Basurto - Montevideo Etorb., 18, Basurtu-Zorrotza, 48013 Bilbo, (Bizkaia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Gonz\u00e1lez Quesada","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Gran Canaria Dr. Negr\u00edn - C. Pl. Barranco de la Ballena, s\/n, 35010 Las Palmas de Gran Canaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Gal\u00e1n Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda - Av. Men\u00e9ndez Pidal, s\/n, Poniente Sur, 14004 C\u00f3rdoba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Gilaberte Calzada","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet - P.\u00ba de Isabel la Cat\u00f3lica, 1-3, 50009 Zaragoza"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Arumi Torredemer","sequence":"additional","affiliation":[{"name":"PFIZER S.L.U. - Avda. Europa, 20, B, 28108 Alcobendas (Madrid)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelia","family":"Llevat Felius","sequence":"additional","affiliation":[{"name":"PFIZER S.L.U. - Avda. 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