{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:25:29Z","timestamp":1789586729069,"version":"build-2803163510"},"reference-count":38,"publisher":"Mattioli1885","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Psoriasis is a chronic inflammatory disease that may lead to scalp involvement, with a significant impact on patients' quality of life. Although most patients with scalp psoriasis do not experience alopecia, alopecia in the context of psoriasis is a multifaceted issue on which studies are limited. Objectives: The purpose of this review was to investigate different types of alopecia in psoriasis and the potential mechanisms. Methods: A thorough literature review was performed, focusing on the relationship between psoriasis and alopecia areata (AA), drug-induced alopecia, and psoriatic alopecia. Results: Psoriasis and alopecia are related through several pathways. Regarding psoriatic alopecia, in most cases of psoriasis patients with scalp involvement, hair loss is attributed to telogen effluvium. In late-stage lesions, destruction of the hair follicle, perifollicular fibrosis, and free bare hair shafts in the dermis are revealed. However, hair loss in psoriasis is almost always non-scarring and reversible. In drug-induced alopecia, both conventional systemic treatments and biologics may cause hair loss in psoriatic patients. Specific side effects have been reported with TNF-\u03b1 inhibitors and IL-17 blockers. TNF-\u03b1 inhibitors may cause several types of alopecia: i) TNF-\u03b1 inhibitor-associated psoriatic alopecia, ii) TNF-\u03b1 inhibitor-associated AA, and iii) TNF-\u03b1 inhibitor-associated lichen planopilaris. In concomitant psoriasis and alopecia areata, there is strong and convincing evidence that patients with psoriasis are at increased risk of developing AA, suggesting a complex interplay of autoimmune mechanisms. Conclusion: Understanding the types and causes of alopecia in patients with psoriasis is crucial to proper management, thus highlighting the need for more research.<\/jats:p>","DOI":"10.5826\/dpc.1504a5283","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:22:04Z","timestamp":1761916924000},"page":"5283","source":"Crossref","is-referenced-by-count":3,"title":["Psoriasis and Alopecia: Unveiling the Links"],"prefix":"10.5826","volume":"15","author":[{"given":"Mohammad Reza","family":"Pourani","sequence":"first","affiliation":[{"name":"Shahid Beheshti University of Medical Sciencesof Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasaman","family":"Khajeamiri","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciencesof Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Abdollahimajd","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciencesof Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Zargari","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciencesof Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"10.5826\/dpc.1504a5283_ref1","unstructured":"Crowley J. 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