{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:42:07Z","timestamp":1789706527757,"version":"4.0.1"},"reference-count":15,"publisher":"Mattioli1885","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: The use of brodalumab in patients with psoriasis who have failed other biologic drugs is an under-explored topic; A variable percentage of patients still experience primary therapeutic failure, incomplete response, or progressive loss of treatment efficacy (secondary therapeutic failure). In this context, switching treatments among different mechanisms of action has been explored in previous studies conducted on psoriatic patients. However, criteria providing a clear clinical rationale for such transitions are lacking, and no clear guidance is provided by international guidelines to date. Objectives: To evaluate the safety and the efficacy of brodalumab in a subgroup of psoriasis patients who already failed anti-IL23 or anti-IL12\/23 treatment. Methods: We retrospectively evaluated, using the PASI and DLQI index, a cohort of 23 patients with psoriasis who underwent a change of therapy with brodalumab exclusively following primary or secondary therapeutic failure of anti-IL-23 or anti-12\/23 drugs. Results: The mean PASI decreased significantly following the introduction of brodalumab after 4 weeks of treatment, and continued to decrease at 16 and 36 weeks, reaching the nadir at 52 weeks (baseline PASI baseline= 14.6 \u00b1 9.2 vs. 52 weeks PASI= 1.1 \u00b1 1.8; p &lt;0.001). The 63.6% of patients reached PASI 100 just after 16 weeks. The same trend of improvement was also observed for the DLQI. The adverse effects observed in our study population were generally mild. Conclusions: Our results are in line with the current literature and suggest that patients who have failed therapy with IL-23 or IL-12\/23 inhibitors may benefit from switching to brodalumab, which could be considered a good choice for patients who need a rapid resolution of the inflammatory skin condition.<\/jats:p>","DOI":"10.5826\/dpc.1504a6010","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:22:52Z","timestamp":1761916972000},"page":"6010","source":"Crossref","is-referenced-by-count":3,"title":["Brodalumab efficacy in psoriasis patients with inadequate response to IL-23 or IL-12\/23 inhibitors: multicenter Italian retrospective analysis - IL PSO (Italian Landscape Psoriasis)"],"prefix":"10.5826","volume":"15","author":[{"given":"Diego","family":"Orsini","sequence":"first","affiliation":[{"name":"San Gallicano Dermatological Institute (IRCCS), Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concetta","family":"Fargnoli","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute (IRCCS), Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Burlando","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences (DiSSal), University of Genoa, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Campanati","sequence":"additional","affiliation":[{"name":"Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60100 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Campione","sequence":"additional","affiliation":[{"name":"Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Guarneri","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morpho Functional Imaging, Section of Dermatology, University of Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Narcisi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital, 10134 Rozzano, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pella","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Ospedale degli Infermi, 13875 Biella, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Romita","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari \"Aldo Moro\", Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Travaglini","sequence":"additional","affiliation":[{"name":"U.O.S.D. 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Corrigendum: Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis. J Eur Acad Dermatol Venereol. 2020 Sep;34(9):2156. DOI: 10.1111\/jdv.16827. Erratum for: J Eur Acad Dermatol Venereol. 2020 Jan;34(1):39-46. DOI: 10.1111\/jdv.15920. PMID: 33448477.","DOI":"10.1111\/jdv.15920"},{"key":"10.5826\/dpc.1504a6010_ref2","doi-asserted-by":"crossref","unstructured":"Dapavo P, Siliquini N, Mastorino L et al. Efficacy, safety, and drug survival of IL-23, IL-17, and TNF-alpha inhibitors for psoriasis treatment: a retrospective study. J Dermatolog Treat. 2022 Jun;33(4):2352-2357. DOI: 10.1080\/09546634.2021.1961998. PMID: 34315331.","DOI":"10.1080\/09546634.2021.1961998"},{"key":"10.5826\/dpc.1504a6010_ref3","doi-asserted-by":"crossref","unstructured":"Mastorino L, Susca S, Cariti C et al. Efficacy of anti-IL-23 and anti-IL-17 after adalimumab failure in psoriatic patients. J Eur Acad Dermatol Venereol. 2023 Sep;37(9):1848-1853. DOI: 10.1111\/jdv.19135. PMID: 37113043.","DOI":"10.1111\/jdv.19135"},{"key":"10.5826\/dpc.1504a6010_ref4","doi-asserted-by":"crossref","unstructured":"Chiricozzi A, Conti A, Burlando M et al. Switching from Secukinumab to Ustekinumab in Psoriasis Patients: Results from a Multicenter Experience. Dermatology. 2019;235(3):213-218. DOI: 10.1159\/000497274. PMID: 30928971.","DOI":"10.1159\/000497274"},{"key":"10.5826\/dpc.1504a6010_ref5","doi-asserted-by":"crossref","unstructured":"Damiani G, Conic RRZ, de Vita et al. When IL-17 inhibitors fail: Real-life evidence to switch from secukinumab to adalimumab or ustekinumab. Dermatol Ther. 2019 Mar;32(2):e12793. DOI: 10.1111\/dth.12793. PMID: 30515970; PMCID: PMC6445726.","DOI":"10.1111\/dth.12793"},{"key":"10.5826\/dpc.1504a6010_ref6","doi-asserted-by":"crossref","unstructured":"Fargnoli MC, Bardazzi F, Bianchi L et al. Brodalumab for the Treatment of Moderate-to-Severe Psoriasis: An Expert Delphi Consensus Statement. 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Long-Term Skin Clearance With Brodalumab in Patients With Psoriasis and Inadequate Response to Prior Biologics. J Drugs Dermatol. 2022 Apr 1;21(4):354-370. DOI: 10.36849\/JDD.6743. PMID: 35389586."},{"key":"10.5826\/dpc.1504a6010_ref13","doi-asserted-by":"crossref","unstructured":"Sun X, Cui Z, Wang Q et al. Formation and clinical effects of anti-drug antibodies against biologics in psoriasis treatment: An analysis of current evidence. Autoimmun Rev. 2024 Apr;23(4):103530. DOI: 10.1016\/j.autrev.2024.103530. PMID: 38499168.","DOI":"10.1016\/j.autrev.2024.103530"},{"key":"10.5826\/dpc.1504a6010_ref14","doi-asserted-by":"crossref","unstructured":"Reich K, Bianchi L, Khemis A et al. Brodalumab Versus Guselkumab in Patients with Moderate-to-Severe Psoriasis with an Inadequate Response to Ustekinumab: A Randomized, Multicenter, Double-Blind Phase 4 Trial (COBRA). Dermatol Ther (Heidelb). 2024 Feb;14(2):453-468. DOI: 10.1007\/s13555-023-01092-x. 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