{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:14:04Z","timestamp":1778688844842,"version":"3.51.4"},"reference-count":55,"publisher":"Mattioli1885","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Systemic autoimmune diseases frequently involve both the skin and eyes, with early cutaneous manifestations often serving as visible indicators of deeper, multisystem pathology. Conditions such as systemic lupus erythematosus, dermatomyositis, sarcoidosis, and Sj\u00f6gren\u2019s syndrome display characteristic skin findings, including malar rash, heliotrope eruption, lupus pernio, or xerosis, which may precede or parallel serious ocular complications, including uveitis, retinal vasculitis, conjunctival granulomas, and keratoconjunctivitis sicca. Despite this overlap, diagnostic and therapeutic strategies remain fragmented across specialties. Objectives: By highlighting the clinical intersections between dermatological and ocular manifestations in systemic autoimmune diseases, we aim to promote earlier recognition, integrated treatment, and improved outcomes for patients affected by these multisystem disorders. Methods: This review synthesizes the literature from the last fifteen years, between 2010 and 2025, on four major autoimmune conditions: systemic lupus erythematosus, dermatomyositis, sarcoidosis, and Sj\u00f6gren\u2019s syndrome. Results: We examine disease-specific immunopathology, diagnostic modalities, and therapeutic strategies, while also discussing the need for interdisciplinary management models, including those that bridge dermatology and ophthalmology. Conclusion: By highlighting these clinical intersections, we aim to promote earlier recognition, integrated treatment, and improved outcomes for patients affected by these multisystem disorders.<\/jats:p>","DOI":"10.5826\/dpc.1602a6931","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:48:44Z","timestamp":1777571324000},"page":"6931","source":"Crossref","is-referenced-by-count":0,"title":["Dermatologic Indicators of Systemic Autoimmune Disease: Clinical Links to Ocular Involvement"],"prefix":"10.5826","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1516-0774","authenticated-orcid":false,"given":"Hana","family":"Abbas","sequence":"first","affiliation":[{"name":"Meharry Medical College, School of Medicine, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarin","family":"Kothari","sequence":"first","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harleen","family":"Multani","sequence":"first","affiliation":[{"name":"Meharry Medical College, School of Medicine, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiratpreet","family":"Sraa","sequence":"first","affiliation":[{"name":"Arizona College of Osteopathic Medicine, Glendale, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1015-7526","authenticated-orcid":false,"given":"Precious Ochuwa","family":"Imokhai","sequence":"first","affiliation":[{"name":"Rocky Vista University, Montana College Of Osteopathic Medicine, Billings, MT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azka","family":"Malik","sequence":"first","affiliation":[{"name":"Royal College of Surgeons in Ireland-Bahrain, Busaiteen, Muharraq, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjana","family":"Kantipudi","sequence":"first","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California San Francisco St. Mary\u2019s Hospital, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27750","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"10.5826\/dpc.1602a6931_ref1","doi-asserted-by":"crossref","unstructured":"Al Akrash LS, Al Semari MA, Al Harithy R. 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