{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:59:19Z","timestamp":1785513559810,"version":"3.56.0"},"reference-count":17,"publisher":"Mattioli1885","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Atopic dermatitis (AD) and inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated disorders with overlapping immunopathogenic mechanisms. Limited research has investigated clinical features of AD and concomitant IBD. Objectives: This study aimed to evaluate the clinical presentation of adult patients with concomitant moderate-to-severe AD and IBD. Methods: Adult patients with moderate-to-severe AD and confirmed IBD were identified across 12 hospital-based dermatology centers between 2022 and 2024 by using electronic records. Results: Thirty-eight out of 4,236 (0.9%) patients with moderate-to-severe AD had verified IBD (19 CD and 19 UC), with a prevalence higher than that expected in the general Italian population (0.9% vs 0.41%). The mean age at AD diagnosis was 25 years, with AD preceding IBD diagnosis with a median interval of 10 years in 71% of cases. At the time of the study, 40% of CD patients and 63% of UC patients were in clinical remission. AD clinical presentation in patients with IBD was typical, with 68% of patients presenting with flexural phenotype, and associated with personal (34%) or family (40%) history of atopy. Conclusions: IBD is not frequent in AD patients, but the prevalence seems to be higher compared to the general population. AD occurring with IBD had a typical clinical presentation. Interestingly, occurrence of AD preceded IBD onset in most patients, putting dermatologists in the position to make early IBD diagnosis. However, no direct causal relationship can be drawn from these findings. Larger, controlled prospective studies are needed to clarify the relationship between AD and IBD.<\/jats:p>","DOI":"10.5826\/dpc.1603a6643","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:07:48Z","timestamp":1785510468000},"page":"6643","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Patients Presenting with Moderate-to-Severe Atopic Dermatitis and Concomitant Inflammatory Bowel Diseases: a Multicenter Retrospective Study"],"prefix":"10.5826","volume":"16","author":[{"given":"Elena","family":"Pezzolo","sequence":"first","affiliation":[{"name":"San Bortolo Hospital, Vicenza"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Napolitano","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Maurelli","sequence":"first","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Foti","sequence":"first","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Jonian Area, Unit of Dermatology, University of Bari Aldo Moro, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Di Lernia","sequence":"first","affiliation":[{"name":"Dermatology Unit, Arcispedale S. Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Ortoncelli","sequence":"first","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariateresa","family":"Rossi","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Dermatology Unit, University of Brescia, Brescia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cataldo","family":"Patruno","sequence":"first","affiliation":[{"name":"Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Esposito","sequence":"first","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. UOSD General and Oncologic Dermatology, San Salvatore Hospital, L'Aquila, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Gori","sequence":"first","affiliation":[{"name":"Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy. Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Gurioli","sequence":"first","affiliation":[{"name":"Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola Malpighi, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylenia","family":"Vallone","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Peccerillo","sequence":"first","affiliation":[{"name":"Dermatology Unit, Arcispedale S. Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Armuzzi","sequence":"first","affiliation":[{"name":"IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Girolomoni","sequence":"first","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"10.5826\/dpc.1603a6643_ref1","doi-asserted-by":"crossref","unstructured":"St\u00e4nder S. Atopic dermatitis. N Engl J Med 2021;384:1136-1143. 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